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TOTE conflict system, Archaeo-Eukaryotic Primase domain
DNA primase small subunit domain-containing protein
DNA primase synthesises the RNA primers for the Okazaki fragments in lagging strand DNA synthesis. DNA primase is a heterodimer of large and small subunits. This family also includes baculovirus late expression factor 1 or LEF-1 proteins. Baculovirus LEF-1 is a DNA primase enzyme [1]. The family also contains many bacterial DNA primases. [1]. 2023935. Mutations in conserved yeast DNA primase domains impair DNA. replication in vivo.. Francesconi S, Longhese MP, Piseri A, Santocanale C, Lucchini G,. Plevani P;. Proc Natl Acad Sci U S A 1991;88:3877-3881.. [2]. 11836407. Baculovirus replication factor LEF-1 is a DNA primase.. Mikhailov VS, Rohrmann GF;. J Virol 2002;76:2287-2297.. [3]. 16027112. Origin and evolution of the archaeo-eukaryotic primase. superfamily and related palm-domain proteins: structural. insights and new members.. Iyer LM, Koonin EV, Leipe DD, Aravind L;. Nucleic Acids Res. 2005;33:3875-3896. (from Pfam)
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