Protein Family Models

TraF protein undergoes proteolytic processing associated with export. The 19 amino acids at the amino terminus of the polypeptides appear to constitute a typical membrane leader peptide - not included in this family, while the remainder of the molecule is predicted to be primarily hydrophilic in character [1]. F plasmid TraF and TraH are required for F pilus assembly and F plasmid transfer, and they are both localised to the outer membrane in the presence of the complete F transfer region, especially TraV, the putative anchor [2]. [1]. 3042757. The product of the F plasmid transfer operon gene, traF, is a periplasmic protein. Wu JH, Kathir P, Ippen-Ihler K;. J Bacteriol. 1988;170:3633-3639. [2]. 20081027. F plasmid TraF and TraH are components of an outer membrane complex involved in conjugation. Arutyunov D, Arenson B, Manchak J, Frost LS;. J Bacteriol. 2010;192:1730-1734. (from Pfam)

Gene:

traF

Date:

2024-10-16

Date:

2024-08-14

This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA). [1]. 8041738. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Chae HZ, Robison K, Poole LB, Church G, Storz G, Rhee SG;. Proc Natl Acad Sci U S A 1994;91:7017-7021. (from Pfam)

Date:

2024-10-16

Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise. (from Pfam)

Date:

2024-08-14

thioredoxin family protein may function as a thiol disulfide reductase that catalyzes the reduction of protein disulfide bonds using an active site dithiol, present in a CXXC motif

Date:

2024-05-06