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Items: 4

1.

M48 family metalloprotease

Peptidase_M48 is the largely extracellular catalytic region of CAAX prenyl protease homologues such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds to form a deep groove/cleft into which the substrate can fit [1,2]. [1]. 23539602. Structure of the integral membrane protein CAAX protease Ste24p. Pryor EE Jr, Horanyi PS, Clark KM, Fedoriw N, Connelly SM, Koszelak-Rosenblum M, Zhu G, Malkowski MG, Wiener MC, Dumont ME;. Science. 2013;339:1600-1604. [2]. 23539603. The structural basis of ZMPSTE24-dependent laminopathies. Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP;. Science. 2013;339:1604-1607. (from Pfam)

GO Terms:
Molecular Function:
metalloendopeptidase activity (GO:0004222)
Biological Process:
proteolysis (GO:0006508)
Date:
2024-10-16
Family Accession:
NF013594.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.

M48 family metallopeptidase

M48 family metallopeptidase contains the HEXXH zinc-binding motif and may function as an intracellular, membrane-associated zinc metalloprotease

Date:
2021-01-08
Family Accession:
11574419
Method:
Sparcle

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