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AAA family ATPase
This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B. (from Pfam)
relaxase domain-containing protein
Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer. TrwC binds to the origin of transfer (oriT) and melts the double helix. [1]. 16540117. Unveiling the Molecular Mechanism of a Conjugative Relaxase: The. Structure of TrwC Complexed with a 27-mer DNA Comprising the. Recognition Hairpin and the Cleavage Site.. Boer R, Russi S, Guasch A, Lucas M, Blanco AG, Perez-Luque R,. Coll M, de la Cruz F;. J Mol Biol. 2006;358:857-869.. [2]. 14625590. Recognition and processing of the origin of transfer DNA by. conjugative relaxase TrwC.. Guasch A, Lucas M, Moncalian G, Cabezas M, Perez-Luque R,. Gomis-Ruth FX, de la Cruz F, Coll M;. Nat Struct Biol. 2003;10:1002-1010.. [3]. 8950267. Functional domains in protein TrwC of plasmid R388: dissected. DNA strand transferase and DNA helicase activities reconstitute. protein function.. Llosa M, Grandoso G, Hernando MA, de la Cruz F;. J Mol Biol. 1996;264:56-67. (from Pfam)
MobF family relaxase
conjugative relaxase TrwC/TraI family protein
conjugative relaxase TrwC/TraI family protein similar to Rhodococcus erythropolis TraA that is required for megaplasmid conjugation
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