Protein Family Models

This domain is part of a dehydratase domain found in diverse PKS enzymes. This domain adopts a HotDog fold. Paper describing PDB structure 2vz8. [1]. 18772430. The crystal structure of a mammalian fatty acid synthase. Maier T, Leibundgut M, Ban N;. Science. 2008;321:1315-1322. Paper describing PDB structure 3el6. [2]. 18952099. Crystal structure of the erythromycin polyketide synthase dehydratase. Keatinge-Clay A;. J Mol Biol. 2008;384:941-953. Paper describing PDB structure 3hhd. [3]. 20132826. Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design. Pappenberger G, Benz J, Gsell B, Hennig M, Ruf A, Stihle M, Thoma R, Rudolph MG;. J Mol Biol. 2010;397:508-519. Paper describing PDB structure 3hrq. [4]. 19847268. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA;. Nature. 2009;461:1139-1143. Paper describing PDB structure 3kg6. [5]. 20152156. Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL;. Structure. 2010;18:94-105. (from Pfam)

Date:

2024-10-16

This entry represents a domain found in a group of proteins mainly found in actinomycetes, including the polyketide synthase extender module SpnB from Saccharopolyspora spinosa. This domain shows a classical Rossmann fold [1]. Paper describing PDB structure 3slk. [1]. 22634636. Divergence of multimodular polyketide synthases revealed by a didomain structure. Zheng J, Gay DC, Demeler B, White MA, Keatinge-Clay AT;. Nat Chem Biol. 2012;8:615-621. (from Pfam)

Date:

2024-10-27

This entry represents the N-terminal HotDog domain of the dehydratase (DH) module of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products [2]. [1]. 18952099. Crystal structure of the erythromycin polyketide synthase dehydratase. Keatinge-Clay A;. J Mol Biol. 2008;384:941-953. [2]. 20152156. Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL;. Structure. 2010;18:94-105. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14