Protein Family Models

This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies. It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA. The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function. [1]. 18992255. Crystal structure of the resuscitation-promoting factor. (DeltaDUF)RpfB from M. tuberculosis.. Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio. R;. J Mol Biol. 2009;385:153-162.. [2]. 15598841. The G5 domain: a potential N-acetylglucosamine recognition. domain involved in biofilm formation.. Bateman A, Holden MT, Yeats C;. Bioinformatics. 2005;21:1301-1303. (from Pfam)

Date:

2024-08-14

This family of proteins are very likely to act as transglycosylase enzymes related to Pfam:PF00062 and Pfam:PF01464. These other families are weakly matched by this family, and include the known active site residues. (from Pfam)

Date:

2024-08-14

This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593 (Swiss:P25357). This protein is involved in sporulation part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis ([2]). The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction with the Pfam:PF07501 domain, which is involved in various cell surface processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells [3]. This domain has a beta grasp fold. Structural description of this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed UBL-G5 [4]. [1]. 12625841. New Knowledge from Old: In silico discovery of novel protein. domains in Streptomyces coelicolor.. Yeats C, Bentley S, Bateman A;. BMC Microbiol 2003;3:3-3.. [2]. 11711434. The S. cerevisiae SET3 complex includes two histone. deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor. of the sporulation gene program.. Pijnappel WW, Schaft D, Roguev A, Shevchenko A, Tekotte H, Wilm. M, Rigaut G, Seraphin B, Aasland R, Stewart AF;. Genes Dev 2001;15:2991-3004.. [3]. 19799629. Resuscitation-promoting factors as lytic enzymes for bacterial. growth and signaling.. Kana BD, Mizrahi V;. FEMS Immunol Med Microbiol. 2010;58:39-50.. [4]. 26549874. The structure of Resuscitation promoting factor B from M.. tuberculosis reveals unexpected ubiquit. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

resuscitation-promoting factor is a cell-wall glycosidase that cleaves cell-wall peptidoglycan and stimulates resuscitation of dormant cells; contains G5 and DUF348 domains

Date:

2019-03-14