Protein Family Models

This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity. (from Pfam)

Date:

2024-08-14

This domain catalyses N-acetyltransferase reactions. (from Pfam)

Date:

2024-08-14

This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer. [1]. 11781092. Two glutamate residues, Glu 208 alpha and Glu 197 beta, are crucial for phosphorylation and dephosphorylation of the active-site histidine residue in succinyl-CoA synthetase. Fraser ME, Joyce MA, Ryan DG, Wolodko WT;. Biochemistry. 2002;41:537-546. (from Pfam)

Date:

2024-10-16

This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases. (from Pfam)

Date:

2024-08-14

This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins. [1]. 9175471. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. Neuwald AF, Landsman D;. Trends Biochem Sci 1997;22:154-155. [2]. 11893502. A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?. Chinenov Y;. Trends Biochem Sci 2002;27:115-117. (from Pfam)

Date:

2024-10-16

bifunctional acetate--CoA ligase family protein/GNAT family N-acetyltransferase containing an N-terminal domain similar to ADP-forming acetate--CoA ligase that catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate, and a C-terminal domain that may catalyze the transfer of an acetyl group from acetyl-CoA to a substrate

Date:

2021-09-02