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segregation/condensation protein A
This is a family of proteins that from part of the condensin complex that regulates chromosome segregation. This is the A subunit, which binds to the ScpB subunit, Pfam:PF04079, and SMC, Pfam:PF02463, to participate in chromosomal partition during cell division [2,3]. The condensin complex pulls DNA away from the mid-cell into both cell halves [1]. These proteins are part of the Kleisin superfamily. [1]. 12667442. Kleisins: a superfamily of bacterial and eukaryotic SMC protein. partners.. Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K,. Eisenhaber F;. Mol Cell 2003;11:571-575.. [2]. 23353789. An asymmetric SMC-kleisin bridge in prokaryotic condensin.. Burmann F, Shin HC, Basquin J, Soh YM, Gimenez-Oya V, Kim YG, Oh. BH, Gruber S;. Nat Struct Mol Biol. 2013;20:371-379.. [3]. 23541893. Molecular basis of SMC ATPase activation: role of internal. structural changes of the regulatory subcomplex ScpAB.. Kamada K, Miyata M, Hirano T;. Structure. 2013;21:581-594. (from Pfam)
segregation and condensation protein A
segregation and condensation protein A (ScpA) functions during chromosome segregation and may form a condensin-like structure with SMC and ScpB
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