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Glutaminase/Asparaginase C-terminal domain
This domain is found at the C-terminus of asparaginase enzymes. [1]. 16216574. Structural basis for tRNA-dependent amidotransferase function.. Schmitt E, Panvert M, Blanquet S, Mechulam Y;. Structure. 2005;13:1421-1433. (from Pfam)
asparaginase domain-containing protein
This is the N-terminal domain of this enzyme. (from Pfam)
asparaginase
asparaginase catalyzes the formation of aspartate from asparagine
type I asparaginase
Two related families of asparaginase are designated type I and type II according to the terminology in E. coli, which has both: L-asparaginase I is a low-affinity enzyme found in the cytoplasm, while L-asparaginase II is a high-affinity secreted enzyme synthesized with a cleavable signal sequence. This model describes L-asparaginases related to type I of E. coli. Archaeal putative asparaginases are of this type but contain an extra ~ 80 residues in a conserved N-terminal region. These archaeal homologs are included in this model.
Converts asparagine to aspartate and ammonia
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