Protein Family Models

This entry represents a conserved region found in Phosphatidate phosphatase APP1 from yeast, which contains the catalytic motif DXDX(T/V) [1,2], present in other Mg+2-dependent phosphatases. This domain has a weak sequence similarity to the haloacid dehalogenase-like domain [1]. APP1 catalyses the dephosphorylation of phosphatidate to yield diacylglycerol and may play a role in vesicular trafficking through its phosphatidate phosphatase activity at cortical actin patches [1,2]. [1]. 23071111. The Saccharomyces cerevisiae actin patch protein App1p is a phosphatidate phosphatase enzyme. Chae M, Han GS, Carman GM;. J Biol Chem. 2012;287:40186-40196. [2]. 23335564. Characterization of the yeast actin patch protein App1p phosphatidate phosphatase. Chae M, Carman GM;. J Biol Chem. 2013;288:6427-6437. (from Pfam)

Date:

2024-10-16

App1 family protein is a DUF2183 domain-containing protein; similar to Saccharomyces cerevisiae phosphatidate phosphatase APP1, which is a Mg(2+)-dependent phosphatidate (PA) phosphatase that catalyzes the dephosphorylation of PA to yield diacylglycerol

Date:

2019-09-23