Protein Family Models

T3SS_needle_E is a family of proteins from the operon that builds and controls the needle of the injection system of type III secretion. The YscE protein, produced by the pathogen Yersinia, assumes a secondary structure composed of two anti-parallel alpha-helices separated by a flexible loop [1]. The family is cytoplasmic and may help to stabilise and prevent early polymerisation of the needle-protein F [2,3]. [1]. 16115870. The PscE-PscF-PscG complex controls type III secretion needle biogenesis in Pseudomonas aeruginosa. Quinaud M, Chabert J, Faudry E, Neumann E, Lemaire D, Pastor A, Elsen S, Dessen A, Attree I;. J Biol Chem. 2005;280:36293-36300. [2]. 18281060. Structural characterization of the Yersinia pestis type III secretion system needle protein YscF in complex with its heterodimeric chaperone YscE/YscG. Sun P, Tropea JE, Austin BP, Cherry S, Waugh DS;. J Mol Biol. 2008;377:819-830. [3]. 22844497. The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection. Galle M, Jin S, Bogaert P, Haegman M, Vandenabeele P, Beyaert R;. PLoS One. 2012;7:e41547. (from Pfam)

Date:

2024-10-16

Gene:

ssaE

Date:

2020-03-04

Gene:

ssaE

Date:

2020-10-26

Members of this family are found exclusively in type III secretion appparatus gene clusters in bacteria. Those bacteria with a protein from this family tend to target animal cells, as does Yersinia pestis. This protein is small (about 70 amino acids) and not well characterized.

Date:

2020-03-03