Protein Family Models

The search results from NCBI sequence alignment indicates a conserved domain belonging to ASCH superfamily [1]. Dali searching results show that the protein is a structurally similar to the PUA domain, suggesting it may be involved in RNA recognition. It has been reported that the deletion of PUA genes results in impaired growth (RluD) and competitive disadvantage (TruB) in Escherichia coli. Suggestions have been put forward that, apart from their usual catalytic role, certain PUS enzymes (e.g. TruB) may also act as chaperones for RNA folding. The interface interaction indicates that the biomolecule of protein NP_809782.1 should be a dimer. [1]. 16322048. The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism. Iyer LM, Burroughs AM, Aravind L;. Bioinformatics. 2005; [Epub ahead of print]DR SCOP; 88697; (from Pfam)

Date:

2024-10-16

The ASCH domain adopts a beta-barrel fold similar to the Pfam:PF01472 domain [1]. It is thought to function as an RNA-binding domain during coactivation, RNA-processing and possibly during prokaryotic translation regulation [1]. [1]. 16322048. The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism. Iyer LM, Burroughs AM, Aravind L;. Bioinformatics. 2005; [Epub ahead of print]DR SCOP; 88697; (from Pfam)

Date:

2024-10-16