Protein Family Models

This family consists of various cation transport proteins (Trk) and V-type sodium ATP synthase subunit J or translocating ATPase J EC:3.6.1.34. These proteins are involved in active sodium up-take utilising ATP in the process. TrkH a member of the family Swiss:P76769 from E. coli is a hydrophobic membrane protein and determines the specificity and kinetics of cation transport by the TrK system in E. coli [2]. [1]. 8948101. Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon. Cziepluch C, Kordes E, Pujol A, Jauniaux JC;. Yeast 1996;12:1471-1474. [2]. 7896723. TrkH and its homolog, TrkG, determine the specificity and kinetics of cation transport by the Trk system of Escherichia coli. Schlosser A, Meldorf M, Stumpe S, Bakker EP, Epstein W;. J Bacteriol 1995;177:1908-1910. [3]. 10629185. Trk1 and Trk2 define the major K(+) transport system in fission yeast. Calero F, Gomez N, Arino J, Ramos J;. J Bacteriol 2000;182:394-399. (from Pfam)

Date:

2024-10-16

Trk system potassium transporter TrkH interacts with Trk system potassium uptake protein TrkA and requires TrkE (sapD) for transport activity (20% more uptake is seen with both SapD and SapF)

Date:

2020-11-19

The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system.

Date:

2022-10-11

Gene:

trkH

Date:

2020-10-26