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Anaphase-promoting complex subunit 4 WD40 domain
Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC, [1]. 12049731. The anaphase-promoting complex: proteolysis in mitosis and beyond. Peters JM;. Mol Cell. 2002;9:931-943. [2]. 16896351. The anaphase promoting complex/cyclosome: a machine designed to destroy. Peters JM;. Nat Rev Mol Cell Biol. 2006;7:644-656. [3]. 19584054. The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast. Ors A, Grimaldi M, Kimata Y, Wilkinson CR, Jones N, Yamano H;. J Biol Chem. 2009;284:23989-23994. (from Pfam)
WD40 repeat-containing protein
WD40 repeat domain-containing protein
WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
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