Protein Family Models for Protein (Select 1520357290) - Protein Family Models

Select item 4182121.

This domain of unknown function appears towards the C-terminus of proteins of the NAD dependent epimerase/dehydratase family (Pfam:PF01370) in bacteria, eukaryotes and archaea. Many of the proteins in which it is found are involved in cell-division inhibition. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF019938.5
Method:: HMM

Select item 4150112.

NmrA family NAD(P)-binding protein

NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi [1]. This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families. [1]. 11726498. The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. Stammers DK, Ren J, Leslie K, Nichols CE, Lamb HK, Cocklin S, Dodds A, Hawkins AR;. EMBO J 2001;20:6619-6626. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF017206.5
Method:: HMM

Select item 4123803.

NAD-dependent epimerase/dehydratase family protein

This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions. [1]. 9174344. Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden HM;. Biochemistry 1997;36:6294-6304. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Date:: 2024-10-16

Family Accession:: NF013530.5
Method:: HMM

Select item 3959334.