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Na+/Pi-cotransporter
This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule [1]. [1]. 9826740. Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Hilfiker H, Hattenhauer O, Traebert M, Forster I, Murer H, Biber J;. Proc Natl Acad Sci U S A 1998;95:14564-14569. (from Pfam)
PhoU domain-containing protein
This family contains phosphate regulatory proteins including PhoU. PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle [1]. The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif. [1]. 15716271. Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters. Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH;. J Biol Chem. 2005;280:15960-15966. (from Pfam)
Na/Pi cotransporter family protein
Na/Pi cotransporter family protein similar to Escherichia coli YjbB
Na/Pi symporter
Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.
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