Protein Family Models

This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme [1]. S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion [2]. This family used to be known as DUF62. This entry represents the C-terminal domain of these enzymes. [1]. 17910070. Crystal structure of a conserved protein of unknown function (MJ1651) from Methanococcus jannaschii. Rao KN, Burley SK, Swaminathan S;. Proteins. 2008;70:572-577. [2]. 18675376. The fluorinase, the chlorinase and the duf-62 enzymes. Deng H, O'Hagan D;. Curr Opin Chem Biol. 2008;12:582-592. (from Pfam)

Date:

2024-10-16

This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme [1]. S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion [2]. This family used to be known as DUF62. [1]. 17910070. Crystal structure of a conserved protein of unknown function (MJ1651) from Methanococcus jannaschii. Rao KN, Burley SK, Swaminathan S;. Proteins. 2008;70:572-577. [2]. 18675376. The fluorinase, the chlorinase and the duf-62 enzymes. Deng H, O'Hagan D;. Curr Opin Chem Biol. 2008;12:582-592. (from Pfam)

Date:

2024-10-16

S-adenosyl-l-methionine (SAM) hydroxide adenosyltransferase family protein such as the chlorinase SalL, which halogenates S-adenosyl-L-methionine with chloride to generate 5'-chloro-5'-deoxyadenosine and L-methionine

Date:

2021-02-03