Protein Family Models

The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase [1]. [1]. 15087448. Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis. Schwarzenbacher R, Stenner-Liewen F, Liewen H, Robinson H, Yuan H, Bossy-Wetzel E, Reed JC, Liddington RC;. J Biol Chem. 2004;279:29320-29324. (from Pfam)

Date:

2024-10-16

TenA family transcriptional regulator similar to Chlamydia trachomatis Chlamydia protein associating with death domains (CADD), a Chlamydia specific toxin that associates with death domains of tumor necrosis factor family (TNF) receptors and induces apoptosis in mammalian cell lines through a Caspase-dependent mechanism

Date:

2020-10-09