Protein Family Models

This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long. (from Pfam)

Date:

2024-08-14

This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development [2]. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally [2]. A related enzyme is also found in plants is Swiss:Q38944 (DET2) a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development [1]. [1]. 8602526. A role for brassinosteroids in light-dependent development of Arabidopsis. Li J, Nagpal P, Vitart V, McMorris TC, Chory J;. Science 1996;272:398-401. [2]. 1686016. Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. Jenkins EP, Hsieh CL, Milatovich A, Normington K, Berman DM, Francke U, Russell DW;. Genomics 1991;11:1102-1112. [3]. 1944596. Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism. Andersson S, Berman DM, Jenkins EP, Russell DW;. Nature 1991;354:159-161. (from Pfam)

Date:

2024-10-16