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TraI-like middle domain
This entry represents a domain found in the middle region of TraI-like proteins (such as Swiss:I1YLR9), following the N-terminal relaxase domain. (from Pfam)
LPD7 domain-containing protein
This domain contains conserved aspartate and phenylalanine residues. It is widely present in polyvalent proteins and gene neighbourhoods of conjugative elements [1]. This domain is also known as PTox1 [2]. [1]. 28559295. Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements. Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;. J Bacteriol. 2017; [Epub ahead of print]. [2]. 25358815. Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids. Maindola P, Raina R, Goyal P, Atmakuri K, Ojha A, Gupta S, Christie PJ, Iyer LM, Aravind L, Arockiasamy A;. Nat Commun. 2014;5:5322. (from Pfam)
relaxase/mobilization nuclease domain-containing protein
Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation. The relaxase, in conjunction with several auxiliary proteins, forms the relaxation complex or relaxosome. Relaxases nick duplex DNA in a specific manner by catalysing trans-esterification [1-3]. This entry represents the nuclease domain of VirD2 and similar sequences. [1]. 9350859. Nicking by transesterification: the reaction catalysed by a relaxase. Byrd DR, Matson SW;. Mol Microbiol 1997;25:1011-1022. [2]. 10940031. Identification of the mob genes of plasmid pSC101 and characterization of a hybrid pSC101-R1162 system for conjugal mobilization. Meyer R;. J Bacteriol 2000;182:4875-4881. [3]. 10482518. Bacterial conjugation protein MobA mediates integration of complex DNA structures into plant cells. Bravo-Angel AM, Gloeckler V, Hohn B, Tinland B;. J Bacteriol 1999;181:5758-5765. (from Pfam)
TraI/MobA(P) family conjugative relaxase
Members of this family of conjugative relaxases are variably named as TraI or as MobA of type P mobilization systems.
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