Protein Family Models

Sulfite and Nitrite reductases are key to both biosynthetic assimilation of sulfur and nitrogen and dissimilation of oxidised anions for energy transduction [1]. Two copies of this repeat are found in Nitrite and Sulfite reductases and form a single structural domain. [1]. 7569952. Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions. Crane BR, Siegel LM, Getzoff ED;. Science 1995;270:59-67. (from Pfam)

Date:

2024-10-16

Sulphite and nitrite reductases are vital in the biosynthetic assimilation of sulphur and nitrogen, respectfully. They are also both important for the dissimilation of oxidised anions for energy transduction. [1]. 7569952. Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions. Crane BR, Siegel LM, Getzoff ED;. Science 1995;270:59-67. [2]. 9315849. Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products. Crane BR, Siegel LM, Getzoff ED;. Biochemistry 1997;36:12120-12137. (from Pfam)

Date:

2024-10-16

assimilatory sulfite reductase (NADPH) hemoprotein subunit is a component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide

Date:

2023-03-14

NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide

Date:

2021-11-04

Sulfite reductase (NADPH) catalyzes a six electron reduction of sulfite to sulfide in prokaryotic organisms. It is a complex oligomeric enzyme composed of two different peptides with a subunit composition of alpha(8)-beta(4) [1]. The alpha component, encoded by cysJ, is a flavoprotein containing both FMN and FAD, while the beta component, encoded by cysI, is a siroheme, iron-sulfur protein [1]. In Salmonella typhimurium and Escherichia coli, both the alpha and beta subunits of sulfite reductase are located in a unidirectional gene cluster along with phosphoadenosine phosphosulfate reductase, which catalyzes a two step reduction of PAPS to give free sulfite [2]. In cyanobacteria and plant species, sulfite reductase ferredoxin (EC 1.8.7.1) catalyzes the reduction of sulfite to sulfide [3].

Gene:

cysI

Date:

2024-06-04