Protein Family Models

Acyl-CoA dehydrogenases catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with reduction of enzyme-bound FAD. They consist of an N-terminal all-alpha domain, a middle open (5,8) barrel domain and a four-helical bundle C-terminal domain. Members of the acyl-CoA dehydrogenase family differ in the number of C-terminal domains. This entry represents the second C-terminal domain, from ACAD9 and Very long-chain specific acyl-CoA dehydrogenase (ACADV) [1]. Paper describing PDB structure 3b96. [1]. 18227065. Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase. McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ;. J Biol Chem. 2008;283:9435-9443. (from Pfam)

Date:

2024-10-16

The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha domain. [1]. 7857927. Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii. Djordjevic S, Pace CP, Stankovich MT, Kim JJ;. Biochemistry. 1995;34:2163-2171. [2]. 8356049. Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. Kim JJ, Wang M, Paschke R;. Proc Natl Acad Sci U S A 1993;90:7523-7527. (from Pfam)

Date:

2024-10-16

Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold. [1]. 7857927. Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii. Djordjevic S, Pace CP, Stankovich MT, Kim JJ;. Biochemistry. 1995;34:2163-2171. [2]. 8356049. Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. Kim JJ, Wang M, Paschke R;. Proc Natl Acad Sci U S A 1993;90:7523-7527. (from Pfam)

Date:

2024-10-16

C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle. [1]. 7857927. Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii. Djordjevic S, Pace CP, Stankovich MT, Kim JJ;. Biochemistry. 1995;34:2163-2171. [2]. 8356049. Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. Kim JJ, Wang M, Paschke R;. Proc Natl Acad Sci U S A 1993;90:7523-7527. [3]. 11514662. Sequence-structure analysis of FAD-containing proteins. Dym O, Eisenberg D;. Protein Sci 2001;10:1712-1728. (from Pfam)

Date:

2024-10-16

acyl-CoA dehydrogenase family protein similar to acyl-CoA dehydrogenase that catalyzes the alpha, beta dehydrogenation of an acyl-CoA to form 2,3-dehydroacyl-CoA requiring an acceptor such as FAD, which becomes reduced..

Date:

2024-04-11