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HD domain-containing phosphohydrolase
HD domains are metal dependent phosphohydrolases [1,2]. This entry covers the HD-GYP domain [2]. [1]. 9868367. The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:469-472. [2]. 34928179. Sequence Conservation, Domain Architectures, and Phylogenetic Distribution of the HD-GYP Type c-di-GMP Phosphodiesterases. Galperin MY, Chou SH;. J Bacteriol. 2021; [Epub ahead of print] (from Pfam)
response regulator
This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain. [1]. 7699720. Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution. Pao GM, Saier MH;. J Mol Evol 1995;40:136-154. (from Pfam)
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