Protein Family Models

This entry represents the D1 domain found in three closely related flagellar proteins usually denoted FlgE, FlgF and FlgG. In FlgE there is an additional domain (D2, Pfam:PF07559) outside D1 [1-5]. The flagellar hook is a short, highly curved tubular structure that connects the flagellar motor to the long filament acting as a helical propeller. Paper describing PDB structure 2bgy. [1]. 15657146. A partial atomic structure for the flagellar hook of Salmonella typhimurium. Shaikh TR, Thomas DR, Chen JZ, Samatey FA, Matsunami H, Imada K, Namba K, Derosier DJ;. Proc Natl Acad Sci U S A. 2005;102:1023-1028. Paper describing PDB structure 3a69. [2]. 19913483. Specific arrangement of alpha-helical coiled coils in the core domain of the bacterial flagellar hook for the universal joint function. Fujii T, Kato T, Namba K;. Structure. 2009;17:1485-1493. Paper describing PDB structure 5az4. [3]. 27759043. Structural insights into bacterial flagellar hooks similarities and specificities. Yoon YH, Barker CS, Bulieris PV, Matsunami H, Samatey FA;. Sci Rep. 2016;6:35552. Paper describing PDB structure 5jxl. [4]. 27811912. Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions. Matsunami H, Barker CS, Yoon YH, Wolf M, Samatey FA;. Nat Commun. 2016;7:13425. Paper describing PDB structure 5npy. [5]. 29083539. Structural characterization of FlgE2 protein from Helicobacter pylori hook. Loconte V, Kekez I, Matkovic-Calogovic D, Zanotti G;. FEBS J. 2017;284:4328-4342. (from Pfam)

Date:

2024-10-16

This family consists of a number of C-terminal domains of unknown function. This domain seems to be specific to flagellar basal-body rod and flagellar hook proteins in which Pfam:PF00460 is often present at the extreme N terminus. [1]. 2129540. FlgB, FlgC, FlgF and FlgG. A family of structurally related proteins in the flagellar basal body of Salmonella typhimurium. Homma M, Kutsukake K, Hasebe M, Iino T, Macnab RM;. J Mol Biol. 1990;211:465-477. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

With FlgB and C, makes up the proximal portion of the flagellar basal body rod

Gene:

flgF

Date:

2022-06-09

flagellar basal body rod protein FlgF is a component of the proximal portion of the basal body central rod of flagellar organelles

Date:

2017-08-28

This model encompasses three closely related flagellar proteins usually denoted FlgE, FlgF and FlgG. The names have often been mis-assigned, however. Three equivalog HMMs, TIGR02489, TIGR02490 and TIGR02488, respectively, separate the individual forms into three genome-context consistent groups. The major differences between these genes are architectural, with variable central sections between relatively conserved N- and C-terminal domains. More distantly related are two other flagellar apparatus familis, FlgC (TIGR01395) which consists of little else but the N-and C-terminal domains and FlgK (TIGR02492) with a substantial but different central domain.

Date:

2019-09-10