Protein Family Models for Gene (Select 89633001) - Protein Family Models

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Items: 4

Select item 3895401.

new record, indexing in progress

Family Accession:

Select item 3477332.

new record, indexing in progress

Family Accession:

Select item 527843.

TlyA family RNA methyltransferase

TlyA family RNA methyltransferase similar to Mycobacterium tuberculosis 16S/23S rRNA (cytidine-2'-O)-methyltransferase and Bacillus subtilis rRNA methyltransferase YqxC

Date:: 2024-08-13

Family Accession:: 11439687
Method:: Sparcle

Select item 196724.

TlyA family rRNA (cytidine-2'-O)-methyltransferase

Members of this family include TlyA from Mycobacterium tuberculosis, an rRNA methylase whose modifications are necessary to confer sensitivity to ribosome-targeting antibiotics capreomycin and viomycin. Homology supports identification as a methyltransferase. However, a parallel literature persists in calling some members hemolysins. Hemolysins are exotoxins that attack blood cell membranes and cause cell rupture, often by forming a pore in the membrane. A recent study (2013) on SCO1782 from Streptomyces coelicolor shows hemolysin activity as earlier described for a homolog from the spirochete Serpula (Treponema) hyodysenteriae and one from Mycobacterium tuberculosis.