Protein Family Models for Gene (Select 75173686) - Protein Family Models

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Select item 2309619.

glutathione-disulfide reductase

glutathione-disulfide reductase catalyzes the reduction of glutathione disulfide (GSSG) to form two molecules of glutathione (GSH); functions in the maintenance of high levels of reduced glutathione in the cytosol

Date:: 2023-03-17

Family Accession:: 11482057
Method:: Sparcle

Select item 14156010.

glutathione-disulfide reductase

The tripeptide glutathione is an important reductant, e.g., for maintaining the cellular thiol/disulfide status and for protecting against reactive oxygen species such as hydrogen peroxide. Glutathione-disulfide reductase regenerates reduced glutathione from oxidized glutathione (glutathione disulfide) + NADPH. This HMM represents one of two closely related subfamilies of glutathione-disulfide reductase. Both are closely related to trypanothione reductase, and separate models are built so each of the three can describe proteins with conserved function. This model describes glutathione-disulfide reductases of animals, yeast, and a number of animal-resident bacteria.

Gene:: gor

GO Terms:

Molecular Function:: glutathione-disulfide reductase (NADPH) activity (GO:0004362)

Biological Process:: glutathione metabolic process (GO:0006749)

Biological Process:: cell redox homeostasis (GO:0045454)

Molecular Function:: flavin adenine dinucleotide binding (GO:0050660)

Molecular Function:: NADP binding (GO:0050661)

Date:: 2024-06-04

Family Accession:: TIGR01421.1
Method:: HMM

Select item 1531011.

glutathione-disulfide reductase

Gene:: gorA

GO Terms:

Molecular Function:: glutathione-disulfide reductase (NADPH) activity (GO:0004362)

Biological Process:: glutathione metabolic process (GO:0006749)

Biological Process:: cell redox homeostasis (GO:0045454)

Molecular Function:: flavin adenine dinucleotide binding (GO:0050660)

Molecular Function:: NADP binding (GO:0050661)

Date:: 2021-07-28

Family Accession:: NF004776.0
Method:: HMM

Protein Family Models

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