Catabolite control protein A is a LacI family global transcriptional regulator found in Gram-positive bacteria. CcpA is involved in repressing carbohydrate utilization genes [ex: alpha-amylase (amyE), acetyl-coenzyme A synthase (acsA)] and in activating genes involved in transporting excess carbon from the cell [ex: acetate kinase (ackA), alpha-acetolactate synthase (alsS)]. Additionally, disruption of CcpA in Bacillus megaterium, Staphylococcus xylosus, Lactobacillus casei and Lactocacillus pentosus also decreases growth rate, which suggests CcpA is involved in the regulation of other metabolic pathways.
- Gene:
- ccpA
GO Terms:- Molecular Function:
- DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)
- Molecular Function:
- DNA binding (GO:0003677)
- Biological Process:
- carbohydrate metabolic process (GO:0005975)
- Biological Process:
- regulation of DNA-templated transcription (GO:0006355)
- Date:
- 2021-05-12