Protein Family Models

Members of this protein family, closely related to eukaryotic 6-pyruvoyl tetrahydrobiopterin synthase enzymes, are the QueD protein of queuosine biosynthesis. Queuosine is a hypermodified base in the wobble position of tRNAs for Tyr, His, Asp, and Asn in many species. This modification, although widespread, appears not to be important for viability. The queuosine precursor made by this enzyme may be converted instead to archeaosine as in some Archaea.

Gene:

queD

Date:

2021-04-27

Members of this family from animals are known to be 6-pyruvoyl tetrahydropterin synthase (EC 4.2.3.12). Bacterial members are 6-carboxytetrahydropterin synthase (EC4.1.2.50), QueD, an enzyme of queuosine biosynthesis. Queuosine is a hypermodified base in the wobble position of some tRNAs in most species. See TIGR03367 for a QueD equivalog model.

Date:

2023-09-25