This HMM describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens.
- Gene:
- msrA
GO Terms:- Biological Process:
- response to oxidative stress (GO:0006979)
- Molecular Function:
- peptide-methionine (S)-S-oxide reductase activity (GO:0008113)
- Biological Process:
- protein repair (GO:0030091)
- Molecular Function:
- L-methionine:thioredoxin-disulfide S-oxidoreductase activity (GO:0033744)
- Date:
- 2021-06-02