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Chain A, CARBONIC ANHYDRASE II

PDB: 1I9Q_A

Identical Proteins FASTA Graphics 

LOCUS       1I9Q_A                   259 aa            linear   PRI 07-FEB-2024
DEFINITION  Chain A, CARBONIC ANHYDRASE II.
ACCESSION   1I9Q_A
VERSION     1I9Q_A
DBSOURCE    pdb: molecule 1I9Q, chain A, release Feb 7, 2024;
            deposition: Mar 20, 2001;
            class: LYASE;
            source: Mmdb_id: 15860, Pdb_id 1: 1I9Q;
            Exp. method: X-ray Diffraction.
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 259)
  AUTHORS   Kim,C.Y., Chandra,P.P., Jain,A. and Christianson,D.W.
  TITLE     Fluoroaromatic-fluoroaromatic interactions between inhibitors bound
            in the crystal lattice of human carbonic anhydrase II
  JOURNAL   J Am Chem Soc 123 (39), 9620-9627 (2001)
   PUBMED   11572683
REFERENCE   2  (residues 1 to 259)
  AUTHORS   Kim,C.-Y., Chandra,P.P., Jain,A. and Christianson,D.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-MAR-2001)
COMMENT     CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH
            4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE.
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     Region          1..258
                     /region_name="alpha_CA_I_II_III_XIII"
                     /note="Carbonic anhydrase alpha, isozymes I, II, and III
                     and XIII. Carbonic anhydrases (CAs) are zinc-containing
                     enzymes that catalyze the reversible hydration of carbon
                     dioxide in a two-step mechanism: a nucleophilic attack of
                     a zinc-bound hydroxide ion on...; cd03119"
                     /db_xref="CDD:239393"
     SecStr          29..33
                     /sec_str_type="sheet"
                     /note="strand 1"
     SecStr          37..40
                     /sec_str_type="sheet"
                     /note="strand 2"
     SecStr          45..50
                     /sec_str_type="sheet"
                     /note="strand 3"
     SecStr          54..62
                     /sec_str_type="sheet"
                     /note="strand 4"
     Site            order(63,91,93,95,105,118,197)
                     /site_type="active"
                     /db_xref="CDD:239393"
     SecStr          63..70
                     /sec_str_type="sheet"
                     /note="strand 5"
     SecStr          76..81
                     /sec_str_type="sheet"
                     /note="strand 6"
     SecStr          86..91
                     /sec_str_type="sheet"
                     /note="strand 7"
     SecStr          92..98
                     /sec_str_type="sheet"
                     /note="strand 8"
     Het             join(bond(93),bond(95),bond(118))
                     /heterogen="(ZN,2055)"
     Site            order(93,95,118)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:239393"
     SecStr          105..109
                     /sec_str_type="sheet"
                     /note="strand 9"
     SecStr          114..123
                     /sec_str_type="sheet"
                     /note="strand 10"
     SecStr          138..148
                     /sec_str_type="sheet"
                     /note="strand 11"
     SecStr          169..176
                     /sec_str_type="sheet"
                     /note="strand 12"
     SecStr          188..194
                     /sec_str_type="sheet"
                     /note="strand 13"
     SecStr          204..211
                     /sec_str_type="sheet"
                     /note="strand 14"
     SecStr          213..216
                     /sec_str_type="sheet"
                     /note="strand 15"
     SecStr          219..226
                     /sec_str_type="helix"
                     /note="helix 1"
     SecStr          240..243
                     /sec_str_type="sheet"
                     /note="strand 16"
     SecStr          254..258
                     /sec_str_type="sheet"
                     /note="strand 17"
ORIGIN      
        1 shhwgygkhn gpehwhkdfp iakgerqspv didthtakyd pslkplsvsy dqatslriln
       61 nghafnvefd dsqdkavlkg gpldgtyrli qfhfhwgsld gqgsehtvdk kkyaaelhlv
      121 hwntkygdvg kavqqpdgla vlgiflkvgs akpglqkvvd vldsiktkgk sadftnfdpr
      181 gllpesldyw typgslttpp llecvtwivl kepisvsseq vlkfrklnfn gegepeelmv
      241 dnwrpaqplk nrqikasfk
//
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