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RecName: Full=G2/mitotic-specific cyclin-B

UniProtKB/Swiss-Prot: P20439.2

Identical Proteins FASTA Graphics 

LOCUS       CCNB_DROME               530 aa            linear   INV 27-NOV-2024
DEFINITION  RecName: Full=G2/mitotic-specific cyclin-B.
ACCESSION   P20439
VERSION     P20439.2
DBSOURCE    UniProtKB: locus CCNB_DROME, accession P20439;
            class: standard.
            extra accessions:Q0E8Y2,Q8MME2,Q9I7V2,Q9TYH6,Q9TYH7,Q9V3F4
            created: Feb 1, 1991.
            sequence updated: Jun 21, 2005.
            annotation updated: Nov 27, 2024.
            xrefs: M33192.1, AAA28436.1, X55542.1, CAA39148.1, AJ006773.1,
            CAA07238.1, CAA07239.1, CAA07240.1, AE013599.5, AAF46904.1,
            AAG22197.1, AAM71123.1, AAM71124.1, AY102682.1, AAM27511.1, A35144,
            NP_726244.1, NP_726245.2, NP_726246.1, NP_726247.1
            xrefs (non-sequence databases): AlphaFoldDB:P20439, SMR:P20439,
            BioGRID:63230, IntAct:P20439, MINT:P20439, STRING:7227.FBpp0071822,
            iPTMnet:P20439, PaxDb:7227-FBpp0071822, DNASU:37618,
            EnsemblMetazoa:FBtr0071911, EnsemblMetazoa:FBpp0071822,
            EnsemblMetazoa:FBgn0000405, EnsemblMetazoa:FBtr0071913,
            EnsemblMetazoa:FBpp0071824, EnsemblMetazoa:FBtr0071914,
            EnsemblMetazoa:FBpp0071825, GeneID:37618, KEGG:dme:Dmel_CG3510,
            AGR:FB:FBgn0000405, CTD:37618, FlyBase:FBgn0000405,
            VEuPathDB:VectorBase:FBgn0000405, eggNOG:KOG0653,
            GeneTree:ENSGT00940000168350, InParanoid:P20439, OMA:VSYKMRA,
            OrthoDB:5474295at2759, PhylomeDB:P20439, Reactome:R-DME-174048,
            Reactome:R-DME-176408, Reactome:R-DME-176412,
            Reactome:R-DME-176417, Reactome:R-DME-2500257,
            Reactome:R-DME-2565942, Reactome:R-DME-3301854,
            Reactome:R-DME-4419969, Reactome:R-DME-6804114,
            Reactome:R-DME-68875, Reactome:R-DME-69273, Reactome:R-DME-69478,
            Reactome:R-DME-75035, Reactome:R-DME-8878166, SignaLink:P20439,
            BioGRID-ORCS:37618, ChiTaRS:CycB, GenomeRNAi:37618, PRO:PR:P20439,
            Proteomes:UP000000803, Bgee:FBgn0000405, ExpressionAtlas:P20439,
            GO:0005813, GO:0000775, GO:0000307, GO:0005737, GO:0005634,
            GO:0051233, GO:0016538, GO:0008608, GO:0001700, GO:0000086,
            GO:0048134, GO:0061952, GO:0044772, GO:0007079, GO:0000281,
            GO:0048137, GO:0035186, CDD:cd20507, CDD:cd20509,
            FunFam:1.10.472.10:FF:000001, Gene3D:1.10.472.10,
            InterPro:IPR039361, InterPro:IPR013763, InterPro:IPR036915,
            InterPro:IPR046965, InterPro:IPR004367, InterPro:IPR006671,
            InterPro:IPR048258, PANTHER:PTHR10177, PANTHER:PTHR10177:SF615,
            Pfam:PF02984, Pfam:PF00134, PIRSF:PIRSF001771, SMART:SM00385,
            SMART:SM01332, SUPFAM:SSF47954, PROSITE:PS00292
KEYWORDS    Alternative splicing; Cell cycle; Cell division; Cyclin; Mitosis;
            Phosphoprotein; Reference proteome.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (residues 1 to 530)
  AUTHORS   Lehner,C.F. and O'Farrell,P.H.
  TITLE     The roles of Drosophila cyclins A and B in mitotic control
  JOURNAL   Cell 61 (3), 535-547 (1990)
   PUBMED   2139805
  REMARK    NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
REFERENCE   2  (residues 1 to 530)
  AUTHORS   Whitfield,W.G., Gonzalez,C., Maldonado-Codina,G. and Glover,D.M.
  TITLE     The A- and B-type cyclins of Drosophila are accumulated and
            destroyed in temporally distinct events that define separable
            phases of the G2-M transition
  JOURNAL   EMBO J 9 (8), 2563-2572 (1990)
   PUBMED   2142452
  REMARK    NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
REFERENCE   3  (residues 1 to 530)
  AUTHORS   Dalby,B. and Glover,D.M.
  TITLE     3' non-translated sequences in Drosophila cyclin B transcripts
            direct posterior pole accumulation late in oogenesis and
            peri-nuclear association in syncytial embryos
  JOURNAL   Development 115 (4), 989-997 (1992)
   PUBMED   1451670
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING
            (ISOFORMS A; B AND C).
REFERENCE   4  (residues 1 to 530)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=Berkeley
REFERENCE   5  (residues 1 to 530)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
  REMARK    GENOME REANNOTATION, AND ALTERNATIVE SPLICING.;
            STRAIN=Berkeley
REFERENCE   6  (residues 1 to 530)
  AUTHORS   Stapleton,M., Carlson,J., Brokstein,P., Yu,C., Champe,M.,
            George,R., Guarin,H., Kronmiller,B., Pacleb,J., Park,S., Wan,K.,
            Rubin,G.M. and Celniker,S.E.
  TITLE     A Drosophila full-length cDNA resource
  JOURNAL   Genome Biol 3 (12), RESEARCH0080 (2002)
   PUBMED   12537569
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).;
            STRAIN=Berkeley; TISSUE=Embryo
REFERENCE   7  (residues 1 to 530)
  AUTHORS   Whitfield,W.G., Gonzalez,C., Sanchez-Herrero,E. and Glover,D.M.
  TITLE     Transcripts of one of two Drosophila cyclin genes become localized
            in pole cells during embryogenesis
  JOURNAL   Nature 338 (6213), 337-340 (1989)
   PUBMED   2564167
  REMARK    NUCLEOTIDE SEQUENCE [MRNA] OF 289-301 AND 343-355.
REFERENCE   8  (residues 1 to 530)
  AUTHORS   Bodenmiller,B., Mueller,L.N., Pedrioli,P.G., Pflieger,D.,
            Junger,M.A., Eng,J.K., Aebersold,R. and Tao,W.A.
  TITLE     An integrated chemical, mass spectrometric and computational
            strategy for (quantitative) phosphoproteomics: application to
            Drosophila melanogaster Kc167 cells
  JOURNAL   Mol Biosyst 3 (4), 275-286 (2007)
   PUBMED   17372656
  REMARK    PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND
            IDENTIFICATION BY MASS SPECTROMETRY.
REFERENCE   9  (residues 1 to 530)
  AUTHORS   Zhai,B., Villen,J., Beausoleil,S.A., Mintseris,J. and Gygi,S.P.
  TITLE     Phosphoproteome analysis of Drosophila melanogaster embryos
  JOURNAL   J Proteome Res 7 (4), 1675-1682 (2008)
   PUBMED   18327897
  REMARK    PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND
            IDENTIFICATION BY MASS SPECTROMETRY.;
            TISSUE=Embryo
COMMENT     On or before Nov 14, 2006 this sequence version replaced
            gi:74932368, gi:74942760, gi:116175.
            [FUNCTION] Essential for the control of the cell cycle at the G2/M
            (mitosis) transition.
            [SUBUNIT] Interacts with the protein kinase Cdk1 to form a
            serine/threonine kinase holoenzyme complex also known as maturation
            promoting factor (MPF). The cyclin subunit imparts substrate
            specificity to the complex.
            [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
            isoforms=3; Name=A; Synonyms=D; IsoId=P20439-1; Sequence=Displayed;
            Name=B; IsoId=P20439-2; Sequence=VSP_021569; Name=C;
            IsoId=P20439-3; Sequence=VSP_021570.
            [DEVELOPMENTAL STAGE] Accumulates steadily during G2 and is
            abruptly destroyed at mitosis.
            [SIMILARITY] Belongs to the cyclin family. Cyclin AB subfamily.
            {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Drosophila melanogaster"
                     /db_xref="taxon:7227"
     gene            1..530
                     /gene="CycB"
                     /locus_tag="CG3510"
     Protein         1..530
                     /product="G2/mitotic-specific cyclin-B"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..530
                     /region_name="Mature chain"
                     /note="G2/mitotic-specific cyclin-B. /id=PRO_0000080385."
     Region          1..30
                     /region_name="Splicing variant"
                     /note="Missing (in isoform C). /evidence=ECO:0000305.
                     /id=VSP_021570."
     Region          1..12
                     /region_name="Splicing variant"
                     /note="MVGTTLKMRGDE -> MAALEK (in isoform B).
                     /evidence=ECO:0000305. /id=VSP_021569."
     Region          76..152
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          108..142
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17372656,
                     ECO:0000269|PubMed:18327897."
     Region          162
                     /region_name="Conflict"
                     /note="R -> G (in Ref. 1; AAA28436).
                     /evidence=ECO:0000305."
     Region          254..384
                     /region_name="CYCLIN_CCNB1-like_rpt1"
                     /note="first cyclin box found in cyclin-B1 (CCNB1)-like
                     family; cd20507"
                     /db_xref="CDD:410211"
     Site            order(256..257,260..261,264..265,268,342..343,346..350,
                     353..355,372,375..376,379..380,383..384)
                     /site_type="other"
                     /note="CDK interface [polypeptide binding]"
                     /db_xref="CDD:410211"
     Region          383
                     /region_name="Conflict"
                     /note="D -> N (in Ref. 2; CAA39148).
                     /evidence=ECO:0000305."
     Region          389..509
                     /region_name="CYCLIN_CCNB1-like_rpt2"
                     /note="second cyclin box found in cyclin-B1 (CCNB1)-like
                     family; cd20509"
                     /db_xref="CDD:410213"
     Region          515
                     /region_name="Conflict"
                     /note="L -> P (in Ref. 2; CAA39148).
                     /evidence=ECO:0000305."
ORIGIN      
        1 mvgttlkmrg denasenfkq vqlkkltvps meattkraal gdlqnrgisr piaakdaaqk
       61 dskdlkltda lrnakarvds hwkkqplgst ngngngavpp kvneggvsaf lrsnsvrnrv
      121 ptkttveptk vtvkssssen vneptlkred snlskksltk lraalakpvm gvsgirrepv
      181 avsrkeaetk kelpetkkds levkkdatrm plirgnsavt tttstmpttm slsskrlagi
      241 edidandken lvlvseyvnd iydylyqvel eqpihkdhla gqkevshkmr avlidwinev
      301 hlqfhlaaet fqlavaiidr ylqvvkdtkr tylqlvgvta lfiatkyeel fppaigdfvf
      361 itddtytarq irqmelqifk aidcnlsrpl pihflrrysk aagaedehht mskyfielas
      421 vdyematyrp seiaaaslfl slhllngnhr agtgfndrhw tptltfysry saahlrpitr
      481 liaklardap qaklkaiynk yqgskfqkia lrteltgalm dsivgqsqrk
//
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