LOCUS CCNB_DROME 530 aa linear INV 27-NOV-2024
DEFINITION RecName: Full=G2/mitotic-specific cyclin-B.
ACCESSION P20439
VERSION P20439.2
DBSOURCE UniProtKB: locus CCNB_DROME, accession P20439;
class: standard.
extra accessions:Q0E8Y2,Q8MME2,Q9I7V2,Q9TYH6,Q9TYH7,Q9V3F4
created: Feb 1, 1991.
sequence updated: Jun 21, 2005.
annotation updated: Nov 27, 2024.
xrefs: M33192.1, AAA28436.1, X55542.1, CAA39148.1, AJ006773.1,
CAA07238.1, CAA07239.1, CAA07240.1, AE013599.5, AAF46904.1,
AAG22197.1, AAM71123.1, AAM71124.1, AY102682.1, AAM27511.1, A35144,
NP_726244.1, NP_726245.2, NP_726246.1, NP_726247.1
xrefs (non-sequence databases): AlphaFoldDB:P20439, SMR:P20439,
BioGRID:63230, IntAct:P20439, MINT:P20439, STRING:7227.FBpp0071822,
iPTMnet:P20439, PaxDb:7227-FBpp0071822, DNASU:37618,
EnsemblMetazoa:FBtr0071911, EnsemblMetazoa:FBpp0071822,
EnsemblMetazoa:FBgn0000405, EnsemblMetazoa:FBtr0071913,
EnsemblMetazoa:FBpp0071824, EnsemblMetazoa:FBtr0071914,
EnsemblMetazoa:FBpp0071825, GeneID:37618, KEGG:dme:Dmel_CG3510,
AGR:FB:FBgn0000405, CTD:37618, FlyBase:FBgn0000405,
VEuPathDB:VectorBase:FBgn0000405, eggNOG:KOG0653,
GeneTree:ENSGT00940000168350, InParanoid:P20439, OMA:VSYKMRA,
OrthoDB:5474295at2759, PhylomeDB:P20439, Reactome:R-DME-174048,
Reactome:R-DME-176408, Reactome:R-DME-176412,
Reactome:R-DME-176417, Reactome:R-DME-2500257,
Reactome:R-DME-2565942, Reactome:R-DME-3301854,
Reactome:R-DME-4419969, Reactome:R-DME-6804114,
Reactome:R-DME-68875, Reactome:R-DME-69273, Reactome:R-DME-69478,
Reactome:R-DME-75035, Reactome:R-DME-8878166, SignaLink:P20439,
BioGRID-ORCS:37618, ChiTaRS:CycB, GenomeRNAi:37618, PRO:PR:P20439,
Proteomes:UP000000803, Bgee:FBgn0000405, ExpressionAtlas:P20439,
GO:0005813, GO:0000775, GO:0000307, GO:0005737, GO:0005634,
GO:0051233, GO:0016538, GO:0008608, GO:0001700, GO:0000086,
GO:0048134, GO:0061952, GO:0044772, GO:0007079, GO:0000281,
GO:0048137, GO:0035186, CDD:cd20507, CDD:cd20509,
FunFam:1.10.472.10:FF:000001, Gene3D:1.10.472.10,
InterPro:IPR039361, InterPro:IPR013763, InterPro:IPR036915,
InterPro:IPR046965, InterPro:IPR004367, InterPro:IPR006671,
InterPro:IPR048258, PANTHER:PTHR10177, PANTHER:PTHR10177:SF615,
Pfam:PF02984, Pfam:PF00134, PIRSF:PIRSF001771, SMART:SM00385,
SMART:SM01332, SUPFAM:SSF47954, PROSITE:PS00292
KEYWORDS Alternative splicing; Cell cycle; Cell division; Cyclin; Mitosis;
Phosphoprotein; Reference proteome.
SOURCE Drosophila melanogaster (fruit fly)
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE 1 (residues 1 to 530)
AUTHORS Lehner,C.F. and O'Farrell,P.H.
TITLE The roles of Drosophila cyclins A and B in mitotic control
JOURNAL Cell 61 (3), 535-547 (1990)
PUBMED 2139805
REMARK NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
REFERENCE 2 (residues 1 to 530)
AUTHORS Whitfield,W.G., Gonzalez,C., Maldonado-Codina,G. and Glover,D.M.
TITLE The A- and B-type cyclins of Drosophila are accumulated and
destroyed in temporally distinct events that define separable
phases of the G2-M transition
JOURNAL EMBO J 9 (8), 2563-2572 (1990)
PUBMED 2142452
REMARK NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
REFERENCE 3 (residues 1 to 530)
AUTHORS Dalby,B. and Glover,D.M.
TITLE 3' non-translated sequences in Drosophila cyclin B transcripts
direct posterior pole accumulation late in oogenesis and
peri-nuclear association in syncytial embryos
JOURNAL Development 115 (4), 989-997 (1992)
PUBMED 1451670
REMARK NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING
(ISOFORMS A; B AND C).
REFERENCE 4 (residues 1 to 530)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
PUBMED 10731132
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=Berkeley
REFERENCE 5 (residues 1 to 530)
AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
Rubin,G.M. and Lewis,S.E.
TITLE Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review
JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002)
PUBMED 12537572
REMARK GENOME REANNOTATION, AND ALTERNATIVE SPLICING.;
STRAIN=Berkeley
REFERENCE 6 (residues 1 to 530)
AUTHORS Stapleton,M., Carlson,J., Brokstein,P., Yu,C., Champe,M.,
George,R., Guarin,H., Kronmiller,B., Pacleb,J., Park,S., Wan,K.,
Rubin,G.M. and Celniker,S.E.
TITLE A Drosophila full-length cDNA resource
JOURNAL Genome Biol 3 (12), RESEARCH0080 (2002)
PUBMED 12537569
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).;
STRAIN=Berkeley; TISSUE=Embryo
REFERENCE 7 (residues 1 to 530)
AUTHORS Whitfield,W.G., Gonzalez,C., Sanchez-Herrero,E. and Glover,D.M.
TITLE Transcripts of one of two Drosophila cyclin genes become localized
in pole cells during embryogenesis
JOURNAL Nature 338 (6213), 337-340 (1989)
PUBMED 2564167
REMARK NUCLEOTIDE SEQUENCE [MRNA] OF 289-301 AND 343-355.
REFERENCE 8 (residues 1 to 530)
AUTHORS Bodenmiller,B., Mueller,L.N., Pedrioli,P.G., Pflieger,D.,
Junger,M.A., Eng,J.K., Aebersold,R. and Tao,W.A.
TITLE An integrated chemical, mass spectrometric and computational
strategy for (quantitative) phosphoproteomics: application to
Drosophila melanogaster Kc167 cells
JOURNAL Mol Biosyst 3 (4), 275-286 (2007)
PUBMED 17372656
REMARK PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND
IDENTIFICATION BY MASS SPECTROMETRY.
REFERENCE 9 (residues 1 to 530)
AUTHORS Zhai,B., Villen,J., Beausoleil,S.A., Mintseris,J. and Gygi,S.P.
TITLE Phosphoproteome analysis of Drosophila melanogaster embryos
JOURNAL J Proteome Res 7 (4), 1675-1682 (2008)
PUBMED 18327897
REMARK PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND
IDENTIFICATION BY MASS SPECTROMETRY.;
TISSUE=Embryo
COMMENT On or before Nov 14, 2006 this sequence version replaced
gi:74932368, gi:74942760, gi:116175.
[FUNCTION] Essential for the control of the cell cycle at the G2/M
(mitosis) transition.
[SUBUNIT] Interacts with the protein kinase Cdk1 to form a
serine/threonine kinase holoenzyme complex also known as maturation
promoting factor (MPF). The cyclin subunit imparts substrate
specificity to the complex.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
isoforms=3; Name=A; Synonyms=D; IsoId=P20439-1; Sequence=Displayed;
Name=B; IsoId=P20439-2; Sequence=VSP_021569; Name=C;
IsoId=P20439-3; Sequence=VSP_021570.
[DEVELOPMENTAL STAGE] Accumulates steadily during G2 and is
abruptly destroyed at mitosis.
[SIMILARITY] Belongs to the cyclin family. Cyclin AB subfamily.
{ECO:0000305}.
FEATURES Location/Qualifiers
source 1..530
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
gene 1..530
/gene="CycB"
/locus_tag="CG3510"
Protein 1..530
/product="G2/mitotic-specific cyclin-B"
/UniProtKB_evidence="Evidence at protein level"
Region 1..530
/region_name="Mature chain"
/note="G2/mitotic-specific cyclin-B. /id=PRO_0000080385."
Region 1..30
/region_name="Splicing variant"
/note="Missing (in isoform C). /evidence=ECO:0000305.
/id=VSP_021570."
Region 1..12
/region_name="Splicing variant"
/note="MVGTTLKMRGDE -> MAALEK (in isoform B).
/evidence=ECO:0000305. /id=VSP_021569."
Region 76..152
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 108..142
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Site 137
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000269|PubMed:17372656,
ECO:0000269|PubMed:18327897."
Region 162
/region_name="Conflict"
/note="R -> G (in Ref. 1; AAA28436).
/evidence=ECO:0000305."
Region 254..384
/region_name="CYCLIN_CCNB1-like_rpt1"
/note="first cyclin box found in cyclin-B1 (CCNB1)-like
family; cd20507"
/db_xref="CDD:410211"
Site order(256..257,260..261,264..265,268,342..343,346..350,
353..355,372,375..376,379..380,383..384)
/site_type="other"
/note="CDK interface [polypeptide binding]"
/db_xref="CDD:410211"
Region 383
/region_name="Conflict"
/note="D -> N (in Ref. 2; CAA39148).
/evidence=ECO:0000305."
Region 389..509
/region_name="CYCLIN_CCNB1-like_rpt2"
/note="second cyclin box found in cyclin-B1 (CCNB1)-like
family; cd20509"
/db_xref="CDD:410213"
Region 515
/region_name="Conflict"
/note="L -> P (in Ref. 2; CAA39148).
/evidence=ECO:0000305."
ORIGIN
1 mvgttlkmrg denasenfkq vqlkkltvps meattkraal gdlqnrgisr piaakdaaqk
61 dskdlkltda lrnakarvds hwkkqplgst ngngngavpp kvneggvsaf lrsnsvrnrv
121 ptkttveptk vtvkssssen vneptlkred snlskksltk lraalakpvm gvsgirrepv
181 avsrkeaetk kelpetkkds levkkdatrm plirgnsavt tttstmpttm slsskrlagi
241 edidandken lvlvseyvnd iydylyqvel eqpihkdhla gqkevshkmr avlidwinev
301 hlqfhlaaet fqlavaiidr ylqvvkdtkr tylqlvgvta lfiatkyeel fppaigdfvf
361 itddtytarq irqmelqifk aidcnlsrpl pihflrrysk aagaedehht mskyfielas
421 vdyematyrp seiaaaslfl slhllngnhr agtgfndrhw tptltfysry saahlrpitr
481 liaklardap qaklkaiynk yqgskfqkia lrteltgalm dsivgqsqrk
//