LOCUS RPN2_ENCCU 786 aa linear PLN 29-MAY-2024
DEFINITION RecName: Full=26S proteasome regulatory subunit RPN2.
ACCESSION Q8SSH5
VERSION Q8SSH5.1
DBSOURCE UniProtKB: locus RPN2_ENCCU, accession Q8SSH5;
class: standard.
created: Sep 1, 2009.
sequence updated: Jun 1, 2002.
annotation updated: May 29, 2024.
xrefs: AL590442.1, CAD25079.1, NP_584575.1
xrefs (non-sequence databases): AlphaFoldDB:Q8SSH5, SMR:Q8SSH5,
STRING:284813.Q8SSH5, GeneID:858565, KEGG:ecu:ECU02_0480,
VEuPathDB:MicrosporidiaDB:ECU02_0480, HOGENOM:CLU_019837_0_0_1,
InParanoid:Q8SSH5, OMA:INYYNIC, OrthoDB:1343092at2759,
Proteomes:UP000000819, GO:0005634, GO:0008540, GO:0034515,
GO:0030234, GO:0043161, GO:0042176, Gene3D:1.25.10.10,
InterPro:IPR016642, InterPro:IPR011989, InterPro:IPR016024,
PANTHER:PTHR10943, PANTHER:PTHR10943:SF2, Pfam:PF13646,
PIRSF:PIRSF015947, SUPFAM:SSF48371
KEYWORDS Cytoplasm; Nucleus; Proteasome; Reference proteome; Repeat.
SOURCE Encephalitozoon cuniculi GB-M1
ORGANISM Encephalitozoon cuniculi GB-M1
Eukaryota; Fungi; Fungi incertae sedis; Microsporidia;
Unikaryonidae; Encephalitozoon.
REFERENCE 1 (residues 1 to 786)
AUTHORS Katinka,M.D., Duprat,S., Cornillot,E., Metenier,G., Thomarat,F.,
Prensier,G., Barbe,V., Peyretaillade,E., Brottier,P., Wincker,P.,
Delbac,F., El Alaoui,H., Peyret,P., Saurin,W., Gouy,M.,
Weissenbach,J. and Vivares,C.P.
TITLE Genome sequence and gene compaction of the eukaryote parasite
Encephalitozoon cuniculi
JOURNAL Nature 414 (6862), 450-453 (2001)
PUBMED 11719806
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=GB-M1
REFERENCE 2 (residues 1 to 786)
AUTHORS Brosson,D., Kuhn,L., Delbac,F., Garin,J., P Vivares,C. and
Texier,C.
TITLE Proteomic analysis of the eukaryotic parasite Encephalitozoon
cuniculi (microsporidia): a reference map for proteins expressed in
late sporogonial stages
JOURNAL Proteomics 6 (12), 3625-3635 (2006)
PUBMED 16691553
REMARK IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
DEVELOPMENTAL STAGE.
COMMENT [FUNCTION] Acts as a regulatory subunit of the 26S proteasome which
degrades poly-ubiquitinated proteins in the cytoplasm and in the
nucleus. It is essential for the regulated turnover of proteins and
for the removal of misfolded proteins. The proteasome is a
multicatalytic proteinase complex that is characterized by its
ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu
adjacent to the leaving group at neutral or slightly basic pH (By
similarity). {ECO:0000250}.
[SUBUNIT] The 26S proteasome consists of a 20S proteasome core and
two 19S regulatory subunits. The 20S proteasome core is composed of
28 subunits that are arranged in four stacked rings, resulting in a
barrel-shaped structure. The two end rings are each formed by seven
alpha subunits, and the two central rings are each formed by seven
beta subunits. The catalytic chamber with the active sites is on
the inside of the barrel (By similarity). {ECO:0000250}.
[SUBCELLULAR LOCATION] Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}.
[DEVELOPMENTAL STAGE] Expressed in late sporogonial stages.
{ECO:0000269|PubMed:16691553}.
[SIMILARITY] Belongs to the proteasome subunit S1 family.
{ECO:0000305}.
FEATURES Location/Qualifiers
source 1..786
/organism="Encephalitozoon cuniculi GB-M1"
/db_xref="taxon:284813"
gene 1..786
/gene="RPN2"
/locus_tag="ECU02_0480"
Protein 1..786
/product="26S proteasome regulatory subunit RPN2"
/UniProtKB_evidence="Evidence at protein level"
Region 1..786
/region_name="RPN2"
/note="26S proteasome regulatory complex component
[Posttranslational modification, protein turnover,
chaperones]; COG5116"
/db_xref="CDD:227446"
Region 1..786
/region_name="Mature chain"
/note="26S proteasome regulatory subunit RPN2.
/id=PRO_0000382762."
Region 311..343
/region_name="Repetitive region"
/note="PC 1."
Region 344..377
/region_name="Repetitive region"
/note="PC 2."
Region 382..416
/region_name="Repetitive region"
/note="PC 3."
Region 417..451
/region_name="Repetitive region"
/note="PC 4."
Region 498..532
/region_name="Repetitive region"
/note="PC 5."
Region 533..566
/region_name="Repetitive region"
/note="PC 6."
Region 548..574
/region_name="HEAT repeat"
/note="HEAT repeat [structural motif]"
/db_xref="CDD:293787"
Region 567..601
/region_name="Repetitive region"
/note="PC 7."
ORIGIN
1 mqtirilpni rallrdgres eaidvinahv dvvaphikdd lryikssdpk tslclskiyf
61 vledyqqaie yalragdllv ddgsfyytsi vyhmmdsadi ggddrirdfv lkvigaedvd
121 dsligylfsi kaygllkeal vkyisdgndc rrlldllisl geeegclkei ygmlaeigpg
181 kkpfifyvid ayfyledvek vkalierlvk edillcydva fytednyspe ievadqrvms
241 ilsgefkkki lgaflleknl tsfkflesia rtrthylgla nslmnlgtsn dtlyrnnadi
301 fgqssewakf sevasigmih lfnsnpyeil knylpsevsq keggalmalg likagtfsee
361 dteyllyfld tedtltpela ygvclglgli nmgsanreil nklkelskvd rtllveasvy
421 gmgmlglnsw svelledlrt iageteferv kravgisfsl vlmfseemfy decnasngdf
481 knyinellyd kdsimrangv lslgsafvgt grlgvistll pyindgdddv kraaviaigl
541 vccddrdllv gtleplsenh nffvraavav vlglflsgtg dkvctnilea lmydtnslvr
601 qsacigvgfi tmqcnpelvp nykriiekln rlivdkkesg avelgavlgr glsegggrni
661 vfsvrnmsgi tsadriagav lflhywywhp lismvslcal pttvfcfned leeeeieipt
721 ssrynnllic lpdikkarrf kqkpkedkei viespsvltf gsrctikqre ecgidapail
781 fvkkkk
//