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RecName: Full=Serine hydroxymethyltransferase 7; Short=AtSHMT7; AltName: Full=Glycine hydroxymethyltransferase 7; AltName: Full=Serine methylase 7

UniProtKB/Swiss-Prot: Q84WV0.1

Identical Proteins FASTA Graphics 

LOCUS       GLYC7_ARATH              598 aa            linear   PLN 27-NOV-2024
DEFINITION  RecName: Full=Serine hydroxymethyltransferase 7; Short=AtSHMT7;
            AltName: Full=Glycine hydroxymethyltransferase 7; AltName:
            Full=Serine methylase 7.
ACCESSION   Q84WV0
VERSION     Q84WV0.1
DBSOURCE    UniProtKB: locus GLYC7_ARATH, accession Q84WV0;
            class: standard.
            extra accessions:Q8LFB5,Q9C8X6
            created: May 29, 2013.
            sequence updated: Jun 1, 2003.
            annotation updated: Nov 27, 2024.
            xrefs: AC021199.7, AAG52195.1, CP002684.1, AEE31862.1, BT002738.1,
            AAO22567.1, AY084945.1, AAM61506.1, F86484, NP_564473.1, 7QX8_A,
            7QX8_B, 7QX8_C, 7QX8_D, 7QX8_E, 7QX8_F, 7QX8_G, 7QX8_H, 7QX8_I,
            7QX8_J, 7QX8_K, 7QX8_L
            xrefs (non-sequence databases): PDBsum:7QX8, AlphaFoldDB:Q84WV0,
            SMR:Q84WV0, STRING:3702.Q84WV0, iPTMnet:Q84WV0,
            PaxDb:3702-AT1G36370.1, ProteomicsDB:248529,
            EnsemblPlants:AT1G36370.1, EnsemblPlants:AT1G36370.1,
            EnsemblPlants:AT1G36370, GeneID:840543, Gramene:AT1G36370.1,
            KEGG:ath:AT1G36370, Araport:AT1G36370, TAIR:AT1G36370,
            eggNOG:KOG2467, HOGENOM:CLU_022477_0_1_1, InParanoid:Q84WV0,
            OMA:WGDQPLH, OrthoDB:5358603at2759, PhylomeDB:Q84WV0,
            BioCyc:ARA:AT1G36370-MONOMER, UniPathway:UPA00193, PRO:PR:Q84WV0,
            Proteomes:UP000006548, ExpressionAtlas:Q84WV0, GO:0005737,
            GO:0005634, GO:0004372, GO:0030170, GO:0019264, GO:0046686,
            GO:0046500, GO:0055063, GO:0035999, CDD:cd00378,
            FunFam:3.40.640.10:FF:000097, Gene3D:3.90.1150.10,
            Gene3D:3.40.640.10, HAMAP:MF_00051, InterPro:IPR015424,
            InterPro:IPR015421, InterPro:IPR015422, InterPro:IPR001085,
            InterPro:IPR049943, InterPro:IPR019798, InterPro:IPR039429,
            PANTHER:PTHR11680, PANTHER:PTHR11680:SF7, Pfam:PF00464,
            SUPFAM:SSF53383, PROSITE:PS00096
KEYWORDS    3D-structure; Cytoplasm; One-carbon metabolism; Pyridoxal
            phosphate; Reference proteome; Transferase.
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (residues 1 to 598)
  AUTHORS   Theologis,A., Ecker,J.R., Palm,C.J., Federspiel,N.A., Kaul,S.,
            White,O., Alonso,J., Altafi,H., Araujo,R., Bowman,C.L.,
            Brooks,S.Y., Buehler,E., Chan,A., Chao,Q., Chen,H., Cheuk,R.F.,
            Chin,C.W., Chung,M.K., Conn,L., Conway,A.B., Conway,A.R.,
            Creasy,T.H., Dewar,K., Dunn,P., Etgu,P., Feldblyum,T.V., Feng,J.,
            Fong,B., Fujii,C.Y., Gill,J.E., Goldsmith,A.D., Haas,B.,
            Hansen,N.F., Hughes,B., Huizar,L., Hunter,J.L., Jenkins,J.,
            Johnson-Hopson,C., Khan,S., Khaykin,E., Kim,C.J., Koo,H.L.,
            Kremenetskaia,I., Kurtz,D.B., Kwan,A., Lam,B., Langin-Hooper,S.,
            Lee,A., Lee,J.M., Lenz,C.A., Li,J.H., Li,Y., Lin,X., Liu,S.X.,
            Liu,Z.A., Luros,J.S., Maiti,R., Marziali,A., Militscher,J.,
            Miranda,M., Nguyen,M., Nierman,W.C., Osborne,B.I., Pai,G.,
            Peterson,J., Pham,P.K., Rizzo,M., Rooney,T., Rowley,D., Sakano,H.,
            Salzberg,S.L., Schwartz,J.R., Shinn,P., Southwick,A.M., Sun,H.,
            Tallon,L.J., Tambunga,G., Toriumi,M.J., Town,C.D., Utterback,T.,
            Van Aken,S., Vaysberg,M., Vysotskaia,V.S., Walker,M., Wu,D., Yu,G.,
            Fraser,C.M., Venter,J.C. and Davis,R.W.
  TITLE     Sequence and analysis of chromosome 1 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 408 (6814), 816-820 (2000)
   PUBMED   11130712
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=cv. Columbia
REFERENCE   2  (residues 1 to 598)
  AUTHORS   Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
            Schobel,S. and Town,C.D.
  TITLE     Araport11: a complete reannotation of the Arabidopsis thaliana
            reference genome
  JOURNAL   Plant J 89 (4), 789-804 (2017)
   PUBMED   27862469
  REMARK    GENOME REANNOTATION.;
            STRAIN=cv. Columbia
REFERENCE   3  (residues 1 to 598)
  AUTHORS   Yamada,K., Lim,J., Dale,J.M., Chen,H., Shinn,P., Palm,C.J.,
            Southwick,A.M., Wu,H.C., Kim,C., Nguyen,M., Pham,P., Cheuk,R.,
            Karlin-Newmann,G., Liu,S.X., Lam,B., Sakano,H., Wu,T., Yu,G.,
            Miranda,M., Quach,H.L., Tripp,M., Chang,C.H., Lee,J.M., Toriumi,M.,
            Chan,M.M., Tang,C.C., Onodera,C.S., Deng,J.M., Akiyama,K.,
            Ansari,Y., Arakawa,T., Banh,J., Banno,F., Bowser,L., Brooks,S.,
            Carninci,P., Chao,Q., Choy,N., Enju,A., Goldsmith,A.D., Gurjal,M.,
            Hansen,N.F., Hayashizaki,Y., Johnson-Hopson,C., Hsuan,V.W.,
            Iida,K., Karnes,M., Khan,S., Koesema,E., Ishida,J., Jiang,P.X.,
            Jones,T., Kawai,J., Kamiya,A., Meyers,C., Nakajima,M., Narusaka,M.,
            Seki,M., Sakurai,T., Satou,M., Tamse,R., Vaysberg,M.,
            Wallender,E.K., Wong,C., Yamamura,Y., Yuan,S., Shinozaki,K.,
            Davis,R.W., Theologis,A. and Ecker,J.R.
  TITLE     Empirical analysis of transcriptional activity in the Arabidopsis
            genome
  JOURNAL   Science 302 (5646), 842-846 (2003)
   PUBMED   14593172
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            STRAIN=cv. Columbia
REFERENCE   4  (residues 1 to 598)
  AUTHORS   Brover,V.V., Troukhan,M.E., Alexandrov,N.A., Lu,Y.-P., Flavell,R.B.
            and Feldmann,K.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-MAR-2002) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
REFERENCE   5  (residues 1 to 598)
  AUTHORS   Bauwe,H. and Kolukisaoglu,U.
  TITLE     Genetic manipulation of glycine decarboxylation
  JOURNAL   J Exp Bot 54 (387), 1523-1535 (2003)
   PUBMED   12730263
  REMARK    REVIEW.
REFERENCE   6  (residues 1 to 598)
  AUTHORS   Zhang,Y., Sun,K., Sandoval,F.J., Santiago,K. and Roje,S.
  TITLE     One-carbon metabolism in plants: characterization of a plastid
            serine hydroxymethyltransferase
  JOURNAL   Biochem J 430 (1), 97-105 (2010)
   PUBMED   20518745
  REMARK    GENE FAMILY.
COMMENT     On or before Jun 5, 2013 this sequence version replaced
            gi:75246061, gi:75262210.
            [FUNCTION] Catalyzes the interconversion of serine and glycine.
            {ECO:0000250}.
            [CATALYTIC ACTIVITY]
            Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine +
            H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine;
            Xref=Rhea:RHEA:15481, ChEBI:CHEBI:15377, ChEBI:CHEBI:15636,
            ChEBI:CHEBI:33384, ChEBI:CHEBI:57305, ChEBI:CHEBI:57453;
            EC=2.1.2.1.
            [COFACTOR] Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
            Evidence={ECO:0000250}.
            [PATHWAY] One-carbon metabolism; tetrahydrofolate interconversion.
            [SUBUNIT] Homotetramer. {ECO:0000250}.
            [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000305}.
            [SIMILARITY] Belongs to the SHMT family. {ECO:0000305}.
            [SEQUENCE CAUTION] Sequence=AAG52195.1; Type=Erroneous initiation;
            Note=Truncated N-terminus.; Evidence={ECO:0000305};
            Sequence=AAM61506.1; Type=Erroneous initiation; Note=Truncated
            N-terminus.; Evidence={ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..598
                     /organism="Arabidopsis thaliana"
                     /db_xref="taxon:3702"
     gene            1..598
                     /gene="SHM7"
                     /locus_tag="At1g36370"
                     /gene_synonym="F7F23.9"
                     /gene_synonym="SHMT7"
     Protein         1..598
                     /product="Serine hydroxymethyltransferase 7"
                     /EC_number="2.1.2.1"
                     /note="AtSHMT7; Glycine hydroxymethyltransferase 7; Serine
                     methylase 7"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..598
                     /region_name="Mature chain"
                     /note="Serine hydroxymethyltransferase 7.
                     /id=PRO_0000422352."
     Region          3..595
                     /region_name="PLN02271"
                     /note="serine hydroxymethyltransferase"
                     /db_xref="CDD:215153"
     Region          57..85
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          64..85
                     /region_name="Compositionally biased region"
                     /note="Basic and acidic residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          123..134
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          138..141
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          143..157
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          159..161
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          171..177
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          180..183
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          192..196
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          199..215
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          220..222
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          223..226
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          232..243
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          249..251
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          275..279
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          280..282
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          289..291
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          292..294
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          296..306
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          299
                     /region_name="Conflict"
                     /note="L -> V (in Ref. 4; AAM61506).
                     /evidence=ECO:0000305."
     Region          309..314
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          324..333
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          337..341
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          343..345
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          346..350
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          357..359
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          362..372
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Site            370
                     /site_type="modified"
                     /note="N6-(pyridoxal phosphate)lysine.
                     /evidence=ECO:0000250."
     Region          378..383
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          407..414
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          415..418
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          424..437
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          440..462
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          468..470
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          473..480
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          482..484
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          488..497
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          503..508
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          514..523
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          524..528
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          533..557
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          561..569
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
     Region          572..585
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
ORIGIN      
        1 mdlsrsqtnf qlgfgcshas mtptptprap iaddsinlqv dqsfrslptt fspiplqlle
       61 qkaektttvd epkkdggggg dqkedehfri lghhmclkrq rdcpllltqs khpkrssigd
      121 sdlesrraav rawgdqpihl adpdihelme kekqrqvrgi eliasenfvc ravmealgsh
      181 ltnkysegmp garyytgnqy idqienlcie raltafgles dkwgvnvqpy sctsanfavy
      241 tglllpgeri mgldspsggh mshgyctpgg kkisaasiff esfpykvnpq tgyidydkle
      301 dkaldyrpki licggssypr dwdfarvrqi adkcgavlmc dmahisglva tkecsnpfdh
      361 cdivtstthk glrgprggii fyrrgpkirk qghhsshcdt sthydleeki nfavfpslqg
      421 gphnnhiaal aialkqvatp eykayiqqmk knaqalaaal lrrkcrlvtg gtdnhlllwd
      481 ltpmgltgkv yekvcemchi tlnktaifgd ngtispggvr igtpamttrg ciesdfetma
      541 dflikaaqit salqrehgks hkefvkslct nkdiaelrnr veafalqyem paslirie
//
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for serine hydroxymethyltransferase 7 (NP_564473.1).

More about the SHM7 gene

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