LOCUS GLYC7_ARATH 598 aa linear PLN 27-NOV-2024
DEFINITION RecName: Full=Serine hydroxymethyltransferase 7; Short=AtSHMT7;
AltName: Full=Glycine hydroxymethyltransferase 7; AltName:
Full=Serine methylase 7.
ACCESSION Q84WV0
VERSION Q84WV0.1
DBSOURCE UniProtKB: locus GLYC7_ARATH, accession Q84WV0;
class: standard.
extra accessions:Q8LFB5,Q9C8X6
created: May 29, 2013.
sequence updated: Jun 1, 2003.
annotation updated: Nov 27, 2024.
xrefs: AC021199.7, AAG52195.1, CP002684.1, AEE31862.1, BT002738.1,
AAO22567.1, AY084945.1, AAM61506.1, F86484, NP_564473.1, 7QX8_A,
7QX8_B, 7QX8_C, 7QX8_D, 7QX8_E, 7QX8_F, 7QX8_G, 7QX8_H, 7QX8_I,
7QX8_J, 7QX8_K, 7QX8_L
xrefs (non-sequence databases): PDBsum:7QX8, AlphaFoldDB:Q84WV0,
SMR:Q84WV0, STRING:3702.Q84WV0, iPTMnet:Q84WV0,
PaxDb:3702-AT1G36370.1, ProteomicsDB:248529,
EnsemblPlants:AT1G36370.1, EnsemblPlants:AT1G36370.1,
EnsemblPlants:AT1G36370, GeneID:840543, Gramene:AT1G36370.1,
KEGG:ath:AT1G36370, Araport:AT1G36370, TAIR:AT1G36370,
eggNOG:KOG2467, HOGENOM:CLU_022477_0_1_1, InParanoid:Q84WV0,
OMA:WGDQPLH, OrthoDB:5358603at2759, PhylomeDB:Q84WV0,
BioCyc:ARA:AT1G36370-MONOMER, UniPathway:UPA00193, PRO:PR:Q84WV0,
Proteomes:UP000006548, ExpressionAtlas:Q84WV0, GO:0005737,
GO:0005634, GO:0004372, GO:0030170, GO:0019264, GO:0046686,
GO:0046500, GO:0055063, GO:0035999, CDD:cd00378,
FunFam:3.40.640.10:FF:000097, Gene3D:3.90.1150.10,
Gene3D:3.40.640.10, HAMAP:MF_00051, InterPro:IPR015424,
InterPro:IPR015421, InterPro:IPR015422, InterPro:IPR001085,
InterPro:IPR049943, InterPro:IPR019798, InterPro:IPR039429,
PANTHER:PTHR11680, PANTHER:PTHR11680:SF7, Pfam:PF00464,
SUPFAM:SSF53383, PROSITE:PS00096
KEYWORDS 3D-structure; Cytoplasm; One-carbon metabolism; Pyridoxal
phosphate; Reference proteome; Transferase.
SOURCE Arabidopsis thaliana (thale cress)
ORGANISM Arabidopsis thaliana
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
Camelineae; Arabidopsis.
REFERENCE 1 (residues 1 to 598)
AUTHORS Theologis,A., Ecker,J.R., Palm,C.J., Federspiel,N.A., Kaul,S.,
White,O., Alonso,J., Altafi,H., Araujo,R., Bowman,C.L.,
Brooks,S.Y., Buehler,E., Chan,A., Chao,Q., Chen,H., Cheuk,R.F.,
Chin,C.W., Chung,M.K., Conn,L., Conway,A.B., Conway,A.R.,
Creasy,T.H., Dewar,K., Dunn,P., Etgu,P., Feldblyum,T.V., Feng,J.,
Fong,B., Fujii,C.Y., Gill,J.E., Goldsmith,A.D., Haas,B.,
Hansen,N.F., Hughes,B., Huizar,L., Hunter,J.L., Jenkins,J.,
Johnson-Hopson,C., Khan,S., Khaykin,E., Kim,C.J., Koo,H.L.,
Kremenetskaia,I., Kurtz,D.B., Kwan,A., Lam,B., Langin-Hooper,S.,
Lee,A., Lee,J.M., Lenz,C.A., Li,J.H., Li,Y., Lin,X., Liu,S.X.,
Liu,Z.A., Luros,J.S., Maiti,R., Marziali,A., Militscher,J.,
Miranda,M., Nguyen,M., Nierman,W.C., Osborne,B.I., Pai,G.,
Peterson,J., Pham,P.K., Rizzo,M., Rooney,T., Rowley,D., Sakano,H.,
Salzberg,S.L., Schwartz,J.R., Shinn,P., Southwick,A.M., Sun,H.,
Tallon,L.J., Tambunga,G., Toriumi,M.J., Town,C.D., Utterback,T.,
Van Aken,S., Vaysberg,M., Vysotskaia,V.S., Walker,M., Wu,D., Yu,G.,
Fraser,C.M., Venter,J.C. and Davis,R.W.
TITLE Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana
JOURNAL Nature 408 (6814), 816-820 (2000)
PUBMED 11130712
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=cv. Columbia
REFERENCE 2 (residues 1 to 598)
AUTHORS Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
Schobel,S. and Town,C.D.
TITLE Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome
JOURNAL Plant J 89 (4), 789-804 (2017)
PUBMED 27862469
REMARK GENOME REANNOTATION.;
STRAIN=cv. Columbia
REFERENCE 3 (residues 1 to 598)
AUTHORS Yamada,K., Lim,J., Dale,J.M., Chen,H., Shinn,P., Palm,C.J.,
Southwick,A.M., Wu,H.C., Kim,C., Nguyen,M., Pham,P., Cheuk,R.,
Karlin-Newmann,G., Liu,S.X., Lam,B., Sakano,H., Wu,T., Yu,G.,
Miranda,M., Quach,H.L., Tripp,M., Chang,C.H., Lee,J.M., Toriumi,M.,
Chan,M.M., Tang,C.C., Onodera,C.S., Deng,J.M., Akiyama,K.,
Ansari,Y., Arakawa,T., Banh,J., Banno,F., Bowser,L., Brooks,S.,
Carninci,P., Chao,Q., Choy,N., Enju,A., Goldsmith,A.D., Gurjal,M.,
Hansen,N.F., Hayashizaki,Y., Johnson-Hopson,C., Hsuan,V.W.,
Iida,K., Karnes,M., Khan,S., Koesema,E., Ishida,J., Jiang,P.X.,
Jones,T., Kawai,J., Kamiya,A., Meyers,C., Nakajima,M., Narusaka,M.,
Seki,M., Sakurai,T., Satou,M., Tamse,R., Vaysberg,M.,
Wallender,E.K., Wong,C., Yamamura,Y., Yuan,S., Shinozaki,K.,
Davis,R.W., Theologis,A. and Ecker,J.R.
TITLE Empirical analysis of transcriptional activity in the Arabidopsis
genome
JOURNAL Science 302 (5646), 842-846 (2003)
PUBMED 14593172
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
STRAIN=cv. Columbia
REFERENCE 4 (residues 1 to 598)
AUTHORS Brover,V.V., Troukhan,M.E., Alexandrov,N.A., Lu,Y.-P., Flavell,R.B.
and Feldmann,K.A.
TITLE Direct Submission
JOURNAL Submitted (??-MAR-2002) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
REFERENCE 5 (residues 1 to 598)
AUTHORS Bauwe,H. and Kolukisaoglu,U.
TITLE Genetic manipulation of glycine decarboxylation
JOURNAL J Exp Bot 54 (387), 1523-1535 (2003)
PUBMED 12730263
REMARK REVIEW.
REFERENCE 6 (residues 1 to 598)
AUTHORS Zhang,Y., Sun,K., Sandoval,F.J., Santiago,K. and Roje,S.
TITLE One-carbon metabolism in plants: characterization of a plastid
serine hydroxymethyltransferase
JOURNAL Biochem J 430 (1), 97-105 (2010)
PUBMED 20518745
REMARK GENE FAMILY.
COMMENT On or before Jun 5, 2013 this sequence version replaced
gi:75246061, gi:75262210.
[FUNCTION] Catalyzes the interconversion of serine and glycine.
{ECO:0000250}.
[CATALYTIC ACTIVITY]
Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine +
H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine;
Xref=Rhea:RHEA:15481, ChEBI:CHEBI:15377, ChEBI:CHEBI:15636,
ChEBI:CHEBI:33384, ChEBI:CHEBI:57305, ChEBI:CHEBI:57453;
EC=2.1.2.1.
[COFACTOR] Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Evidence={ECO:0000250}.
[PATHWAY] One-carbon metabolism; tetrahydrofolate interconversion.
[SUBUNIT] Homotetramer. {ECO:0000250}.
[SUBCELLULAR LOCATION] Cytoplasm {ECO:0000305}.
[SIMILARITY] Belongs to the SHMT family. {ECO:0000305}.
[SEQUENCE CAUTION] Sequence=AAG52195.1; Type=Erroneous initiation;
Note=Truncated N-terminus.; Evidence={ECO:0000305};
Sequence=AAM61506.1; Type=Erroneous initiation; Note=Truncated
N-terminus.; Evidence={ECO:0000305}.
FEATURES Location/Qualifiers
source 1..598
/organism="Arabidopsis thaliana"
/db_xref="taxon:3702"
gene 1..598
/gene="SHM7"
/locus_tag="At1g36370"
/gene_synonym="F7F23.9"
/gene_synonym="SHMT7"
Protein 1..598
/product="Serine hydroxymethyltransferase 7"
/EC_number="2.1.2.1"
/note="AtSHMT7; Glycine hydroxymethyltransferase 7; Serine
methylase 7"
/UniProtKB_evidence="Evidence at protein level"
Region 1..598
/region_name="Mature chain"
/note="Serine hydroxymethyltransferase 7.
/id=PRO_0000422352."
Region 3..595
/region_name="PLN02271"
/note="serine hydroxymethyltransferase"
/db_xref="CDD:215153"
Region 57..85
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 64..85
/region_name="Compositionally biased region"
/note="Basic and acidic residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 123..134
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 138..141
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 143..157
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 159..161
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 171..177
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 180..183
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 192..196
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 199..215
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 220..222
/region_name="Hydrogen bonded turn"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 223..226
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 232..243
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 249..251
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 275..279
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 280..282
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 289..291
/region_name="Hydrogen bonded turn"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 292..294
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 296..306
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 299
/region_name="Conflict"
/note="L -> V (in Ref. 4; AAM61506).
/evidence=ECO:0000305."
Region 309..314
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 324..333
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 337..341
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 343..345
/region_name="Hydrogen bonded turn"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 346..350
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 357..359
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 362..372
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Site 370
/site_type="modified"
/note="N6-(pyridoxal phosphate)lysine.
/evidence=ECO:0000250."
Region 378..383
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 407..414
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 415..418
/region_name="Hydrogen bonded turn"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 424..437
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 440..462
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 468..470
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 473..480
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 482..484
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 488..497
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 503..508
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 514..523
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 524..528
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 533..557
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 561..569
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
Region 572..585
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
ORIGIN
1 mdlsrsqtnf qlgfgcshas mtptptprap iaddsinlqv dqsfrslptt fspiplqlle
61 qkaektttvd epkkdggggg dqkedehfri lghhmclkrq rdcpllltqs khpkrssigd
121 sdlesrraav rawgdqpihl adpdihelme kekqrqvrgi eliasenfvc ravmealgsh
181 ltnkysegmp garyytgnqy idqienlcie raltafgles dkwgvnvqpy sctsanfavy
241 tglllpgeri mgldspsggh mshgyctpgg kkisaasiff esfpykvnpq tgyidydkle
301 dkaldyrpki licggssypr dwdfarvrqi adkcgavlmc dmahisglva tkecsnpfdh
361 cdivtstthk glrgprggii fyrrgpkirk qghhsshcdt sthydleeki nfavfpslqg
421 gphnnhiaal aialkqvatp eykayiqqmk knaqalaaal lrrkcrlvtg gtdnhlllwd
481 ltpmgltgkv yekvcemchi tlnktaifgd ngtispggvr igtpamttrg ciesdfetma
541 dflikaaqit salqrehgks hkefvkslct nkdiaelrnr veafalqyem paslirie
//