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protein S100-A11 [Homo sapiens]

NCBI Reference Sequence: NP_005611.1

Identical Proteins FASTA Graphics 

LOCUS       NP_005611                105 aa            linear   PRI 23-JUL-2024
DEFINITION  protein S100-A11 [Homo sapiens].
ACCESSION   NP_005611
VERSION     NP_005611.1
DBSOURCE    REFSEQ: accession NM_005620.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 105)
  AUTHORS   Deng,C., Xu,Y., Chen,H., Zhu,X., Huang,L., Chen,Z., Xu,H., Song,G.,
            Lu,J., Huang,W., Liu,R., Tang,Q. and Wang,J.
  TITLE     Extracellular-vesicle-packaged S100A11 from osteosarcoma cells
            mediates lung premetastatic niche formation by recruiting gMDSCs
  JOURNAL   Cell Rep 43 (2), 113751 (2024)
   PUBMED   38341855
  REMARK    GeneRIF: Extracellular-vesicle-packaged S100A11 from osteosarcoma
            cells mediates lung premetastatic niche formation by recruiting
            gMDSCs.
REFERENCE   2  (residues 1 to 105)
  AUTHORS   Han,D., Guo,C., Cheng,H., Lu,J., Hou,Z., Zhang,X., Luo,Y.,
            Zhang,B., Zhao,W. and Shang,P.
  TITLE     Downregulation of S100A11 promotes T cell infiltration by
            regulating cancer-associated fibroblasts in prostate cancer
  JOURNAL   Int Immunopharmacol 128, 111323 (2024)
   PUBMED   38286714
  REMARK    GeneRIF: Downregulation of S100A11 promotes T cell infiltration by
            regulating cancer-associated fibroblasts in prostate cancer.
REFERENCE   3  (residues 1 to 105)
  AUTHORS   Zhou,R., Pei,B., Li,X. and Zhang,X.
  TITLE     Involvement of S100A6/S100A11 in T-Cell Immune Regulatory in HCC
            Revealed by Single Cell RNA-seq
  JOURNAL   Technol Cancer Res Treat 23, 15330338241252610 (2024)
   PUBMED   38766816
  REMARK    GeneRIF: Involvement of S100A6/S100A11 in T-Cell Immune Regulatory
            in HCC Revealed by Single Cell RNA-seq.
REFERENCE   4  (residues 1 to 105)
  AUTHORS   He,J., Lei,Y., Li,X., Wu,B. and Tang,Y.
  TITLE     Exploring the prognostic value of S100A11 and its association with
            immune infiltration in breast cancer
  JOURNAL   Sci Rep 13 (1), 22922 (2023)
   PUBMED   38129538
  REMARK    GeneRIF: Exploring the prognostic value of S100A11 and its
            association with immune infiltration in breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 105)
  AUTHORS   Zheng,M., Meng,H., Li,Y., Shi,J., Han,Y., Zhao,C., Chen,J., Han,J.,
            Liang,J., Chen,Y., Liu,Q. and Wang,Y.
  TITLE     S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and
            Has a Diagnostic Role in Hepatocellular Carcinoma
  JOURNAL   Int J Med Sci 20 (3), 318-328 (2023)
   PUBMED   36860671
  REMARK    GeneRIF: S100A11 Promotes Metastasis via AKT and ERK Signaling
            Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 105)
  AUTHORS   Mailliard,W.S., Haigler,H.T. and Schlaepfer,D.D.
  TITLE     Calcium-dependent binding of S100C to the N-terminal domain of
            annexin I
  JOURNAL   J Biol Chem 271 (2), 719-725 (1996)
   PUBMED   8557678
REFERENCE   7  (residues 1 to 105)
  AUTHORS   Tomasetto,C., Regnier,C., Moog-Lutz,C., Mattei,M.G., Chenard,M.P.,
            Lidereau,R., Basset,P. and Rio,M.C.
  TITLE     Identification of four novel human genes amplified and
            overexpressed in breast carcinoma and localized to the q11-q21.3
            region of chromosome 17
  JOURNAL   Genomics 28 (3), 367-376 (1995)
   PUBMED   7490069
REFERENCE   8  (residues 1 to 105)
  AUTHORS   Tanaka,M., Adzuma,K., Iwami,M., Yoshimoto,K., Monden,Y. and
            Itakura,M.
  TITLE     Human calgizzarin; one colorectal cancer-related gene selected by a
            large scale random cDNA sequencing and northern blot analysis
  JOURNAL   Cancer Lett 89 (2), 195-200 (1995)
   PUBMED   7889529
REFERENCE   9  (residues 1 to 105)
  AUTHORS   Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
  TITLE     Isolation of a YAC clone covering a cluster of nine S100 genes on
            human chromosome 1q21: rationale for a new nomenclature of the S100
            calcium-binding protein family
  JOURNAL   Genomics 25 (3), 638-643 (1995)
   PUBMED   7759097
REFERENCE   10 (residues 1 to 105)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D38583.1.
            
            Summary: The protein encoded by this gene is a member of the S100
            family of proteins containing 2 EF-hand calcium-binding motifs.
            S100 proteins are localized in the cytoplasm and/or nucleus of a
            wide range of cells, and involved in the regulation of a number of
            cellular processes such as cell cycle progression and
            differentiation. S100 genes include at least 13 members which are
            located as a cluster on chromosome 1q21. This protein may function
            in motility, invasion, and tubulin polymerization. Chromosomal
            rearrangements and altered expression of this gene have been
            implicated in tumor metastasis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP305686.1, D38583.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271638.3/ ENSP00000271638.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..105
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     Protein         1..105
                     /product="protein S100-A11"
                     /note="calgizzarin; MLN 70; protein S100-C; metastatic
                     lymph node gene 70 protein; epididymis secretory protein
                     Li 43"
                     /calculated_mol_wt=11609
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (P31949.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine, in Protein S100-A11, N-terminally
                     processed. /evidence=ECO:0007744|PubMed:22814378;
                     propagated from UniProtKB/Swiss-Prot (P31949.2)"
     Site            3
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P31949.2)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P31949.2)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P31949.2)"
     Region          7..95
                     /region_name="S-100A11"
                     /note="S-100A11 domain found in proteins similar to
                     S100A11. S100A11 is a member of the S-100 domain family
                     within EF-hand Ca2+-binding proteins superfamily. Note
                     that the S-100 hierarchy, to which this S-100A11 group
                     belongs, contains only S-100 EF-hand...; cd05023"
                     /db_xref="CDD:240150"
     Site            order(8,10..11,13..18,20..22,32,42,46..50,77..78,81..82,
                     84..86,88..89,92..95)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:240150"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:18618420; propagated from
                     UniProtKB/Swiss-Prot (P31949.2)"
     Site            order(25,28,30,33,38,68,70,72,74,79)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:240150"
     Region          25..38
                     /region_name="Calcium binding region"
     Site            27
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50543; propagated from
                     UniProtKB/Swiss-Prot (P31949.2)"
     Site            order(47,49..50,53..54,59,87,90..91,94..95)
                     /site_type="active"
                     /note="annexin I binding site [active]"
                     /db_xref="CDD:240150"
     Region          68..79
                     /region_name="Calcium binding region"
     CDS             1..105
                     /gene="S100A11"
                     /gene_synonym="HEL-S-43; MLN70; S100C"
                     /coded_by="NM_005620.2:90..407"
                     /db_xref="CCDS:CCDS1009.1"
                     /db_xref="GeneID:6282"
                     /db_xref="HGNC:HGNC:10488"
                     /db_xref="MIM:603114"
ORIGIN      
        1 makissptet erciesliav fqkyagkdgy nytlsktefl sfmntelaaf tknqkdpgvl
       61 drmmkkldtn sdgqldfsef lnligglama chdsflkavp sqkrt
//
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Protein 3D Structure

Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the S100A11 gene (NM_005620.2).

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