LOCUS NP_005611 105 aa linear PRI 23-JUL-2024
DEFINITION protein S100-A11 [Homo sapiens].
ACCESSION NP_005611
VERSION NP_005611.1
DBSOURCE REFSEQ: accession NM_005620.2
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 105)
AUTHORS Deng,C., Xu,Y., Chen,H., Zhu,X., Huang,L., Chen,Z., Xu,H., Song,G.,
Lu,J., Huang,W., Liu,R., Tang,Q. and Wang,J.
TITLE Extracellular-vesicle-packaged S100A11 from osteosarcoma cells
mediates lung premetastatic niche formation by recruiting gMDSCs
JOURNAL Cell Rep 43 (2), 113751 (2024)
PUBMED 38341855
REMARK GeneRIF: Extracellular-vesicle-packaged S100A11 from osteosarcoma
cells mediates lung premetastatic niche formation by recruiting
gMDSCs.
REFERENCE 2 (residues 1 to 105)
AUTHORS Han,D., Guo,C., Cheng,H., Lu,J., Hou,Z., Zhang,X., Luo,Y.,
Zhang,B., Zhao,W. and Shang,P.
TITLE Downregulation of S100A11 promotes T cell infiltration by
regulating cancer-associated fibroblasts in prostate cancer
JOURNAL Int Immunopharmacol 128, 111323 (2024)
PUBMED 38286714
REMARK GeneRIF: Downregulation of S100A11 promotes T cell infiltration by
regulating cancer-associated fibroblasts in prostate cancer.
REFERENCE 3 (residues 1 to 105)
AUTHORS Zhou,R., Pei,B., Li,X. and Zhang,X.
TITLE Involvement of S100A6/S100A11 in T-Cell Immune Regulatory in HCC
Revealed by Single Cell RNA-seq
JOURNAL Technol Cancer Res Treat 23, 15330338241252610 (2024)
PUBMED 38766816
REMARK GeneRIF: Involvement of S100A6/S100A11 in T-Cell Immune Regulatory
in HCC Revealed by Single Cell RNA-seq.
REFERENCE 4 (residues 1 to 105)
AUTHORS He,J., Lei,Y., Li,X., Wu,B. and Tang,Y.
TITLE Exploring the prognostic value of S100A11 and its association with
immune infiltration in breast cancer
JOURNAL Sci Rep 13 (1), 22922 (2023)
PUBMED 38129538
REMARK GeneRIF: Exploring the prognostic value of S100A11 and its
association with immune infiltration in breast cancer.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 105)
AUTHORS Zheng,M., Meng,H., Li,Y., Shi,J., Han,Y., Zhao,C., Chen,J., Han,J.,
Liang,J., Chen,Y., Liu,Q. and Wang,Y.
TITLE S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and
Has a Diagnostic Role in Hepatocellular Carcinoma
JOURNAL Int J Med Sci 20 (3), 318-328 (2023)
PUBMED 36860671
REMARK GeneRIF: S100A11 Promotes Metastasis via AKT and ERK Signaling
Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 105)
AUTHORS Mailliard,W.S., Haigler,H.T. and Schlaepfer,D.D.
TITLE Calcium-dependent binding of S100C to the N-terminal domain of
annexin I
JOURNAL J Biol Chem 271 (2), 719-725 (1996)
PUBMED 8557678
REFERENCE 7 (residues 1 to 105)
AUTHORS Tomasetto,C., Regnier,C., Moog-Lutz,C., Mattei,M.G., Chenard,M.P.,
Lidereau,R., Basset,P. and Rio,M.C.
TITLE Identification of four novel human genes amplified and
overexpressed in breast carcinoma and localized to the q11-q21.3
region of chromosome 17
JOURNAL Genomics 28 (3), 367-376 (1995)
PUBMED 7490069
REFERENCE 8 (residues 1 to 105)
AUTHORS Tanaka,M., Adzuma,K., Iwami,M., Yoshimoto,K., Monden,Y. and
Itakura,M.
TITLE Human calgizzarin; one colorectal cancer-related gene selected by a
large scale random cDNA sequencing and northern blot analysis
JOURNAL Cancer Lett 89 (2), 195-200 (1995)
PUBMED 7889529
REFERENCE 9 (residues 1 to 105)
AUTHORS Schafer,B.W., Wicki,R., Engelkamp,D., Mattei,M.G. and Heizmann,C.W.
TITLE Isolation of a YAC clone covering a cluster of nine S100 genes on
human chromosome 1q21: rationale for a new nomenclature of the S100
calcium-binding protein family
JOURNAL Genomics 25 (3), 638-643 (1995)
PUBMED 7759097
REFERENCE 10 (residues 1 to 105)
AUTHORS Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
Vandekerckhove,J.
TITLE Microsequences of 145 proteins recorded in the two-dimensional gel
protein database of normal human epidermal keratinocytes
JOURNAL Electrophoresis 13 (12), 960-969 (1992)
PUBMED 1286667
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from D38583.1.
Summary: The protein encoded by this gene is a member of the S100
family of proteins containing 2 EF-hand calcium-binding motifs.
S100 proteins are localized in the cytoplasm and/or nucleus of a
wide range of cells, and involved in the regulation of a number of
cellular processes such as cell cycle progression and
differentiation. S100 genes include at least 13 members which are
located as a cluster on chromosome 1q21. This protein may function
in motility, invasion, and tubulin polymerization. Chromosomal
rearrangements and altered expression of this gene have been
implicated in tumor metastasis. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BP305686.1, D38583.1 [ECO:0000332]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000271638.3/ ENSP00000271638.2
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..105
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21.3"
Protein 1..105
/product="protein S100-A11"
/note="calgizzarin; MLN 70; protein S100-C; metastatic
lymph node gene 70 protein; epididymis secretory protein
Li 43"
/calculated_mol_wt=11609
Site 1
/site_type="acetylation"
/note="N-acetylmethionine.
/evidence=ECO:0007744|PubMed:22814378; propagated from
UniProtKB/Swiss-Prot (P31949.2)"
Site 2
/site_type="acetylation"
/note="N-acetylalanine, in Protein S100-A11, N-terminally
processed. /evidence=ECO:0007744|PubMed:22814378;
propagated from UniProtKB/Swiss-Prot (P31949.2)"
Site 3
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0007744|PubMed:19608861; propagated from
UniProtKB/Swiss-Prot (P31949.2)"
Site 5
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P31949.2)"
Site 6
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648,
ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163,
ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (P31949.2)"
Region 7..95
/region_name="S-100A11"
/note="S-100A11 domain found in proteins similar to
S100A11. S100A11 is a member of the S-100 domain family
within EF-hand Ca2+-binding proteins superfamily. Note
that the S-100 hierarchy, to which this S-100A11 group
belongs, contains only S-100 EF-hand...; cd05023"
/db_xref="CDD:240150"
Site order(8,10..11,13..18,20..22,32,42,46..50,77..78,81..82,
84..86,88..89,92..95)
/site_type="other"
/note="dimerization interface [polypeptide binding]"
/db_xref="CDD:240150"
Site 10
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0000269|PubMed:18618420; propagated from
UniProtKB/Swiss-Prot (P31949.2)"
Site order(25,28,30,33,38,68,70,72,74,79)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:240150"
Region 25..38
/region_name="Calcium binding region"
Site 27
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P50543; propagated from
UniProtKB/Swiss-Prot (P31949.2)"
Site order(47,49..50,53..54,59,87,90..91,94..95)
/site_type="active"
/note="annexin I binding site [active]"
/db_xref="CDD:240150"
Region 68..79
/region_name="Calcium binding region"
CDS 1..105
/gene="S100A11"
/gene_synonym="HEL-S-43; MLN70; S100C"
/coded_by="NM_005620.2:90..407"
/db_xref="CCDS:CCDS1009.1"
/db_xref="GeneID:6282"
/db_xref="HGNC:HGNC:10488"
/db_xref="MIM:603114"
ORIGIN
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61 drmmkkldtn sdgqldfsef lnligglama chdsflkavp sqkrt
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