LOCUS NP_035069 914 aa linear ROD 19-NOV-2024
DEFINITION neuropilin-2 isoform 3 precursor [Mus musculus].
ACCESSION NP_035069
VERSION NP_035069.2
DBSOURCE REFSEQ: accession NM_010939.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 914)
AUTHORS Vallecillo-Garcia,P., Kuhnlein,M.N., Orgeur,M., Hansmeier,N.R.,
Kotsaris,G., Meisen,Z.G., Timmermann,B., Giesecke-Thiel,C.,
Hagerling,R. and Stricker,S.
TITLE Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel
formation
JOURNAL Development 151 (17) (2024)
PUBMED 39221968
REFERENCE 2 (residues 1 to 914)
AUTHORS Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
TITLE Motor innervation directs the correct development of the mouse
sympathetic nervous system
JOURNAL Nat Commun 15 (1), 7065 (2024)
PUBMED 39152112
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 914)
AUTHORS Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
Tarabykin,V.
TITLE Semaphorin heterodimerization in cis regulates membrane targeting
and neocortical wiring
JOURNAL Nat Commun 15 (1), 7059 (2024)
PUBMED 39152101
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 914)
AUTHORS Benwell,C.J., Johnson,R.T., Taylor,J.A.G.E., Lambert,J. and
Robinson,S.D.
TITLE A proteomics approach to isolating neuropilin-dependent alpha5
integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5
integrin through endosomal p120RasGAP to promote polarised
fibronectin fibrillogenesis in endothelial cells
JOURNAL Commun Biol 7 (1), 629 (2024)
PUBMED 38789481
REMARK GeneRIF: A proteomics approach to isolating neuropilin-dependent
alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic
alpha5 integrin through endosomal p120RasGAP to promote polarised
fibronectin fibrillogenesis in endothelial cells.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 914)
AUTHORS Vosbeck,K., Forster,S., Mayr,T., Sahu,A., Haddouti,E.M.,
Al-Adilee,O., Korber,R.M., Bisht,S., Muders,M.H., Nesic,S.,
Buness,A., Kristiansen,G., Schildberg,F.A. and Gutgemann,I.
TITLE Neuropilin2 in Mesenchymal Stromal Cells as a Potential Novel
Therapeutic Target in Myelofibrosis
JOURNAL Cancers (Basel) 16 (10), 1924 (2024)
PUBMED 38792002
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 914)
AUTHORS Takahashi,T., Fournier,A., Nakamura,F., Wang,L.H., Murakami,Y.,
Kalb,R.G., Fujisawa,H. and Strittmatter,S.M.
TITLE Plexin-neuropilin-1 complexes form functional semaphorin-3A
receptors
JOURNAL Cell 99 (1), 59-69 (1999)
PUBMED 10520994
REFERENCE 7 (residues 1 to 914)
AUTHORS Lozonschi,L., Sunamura,M., Kobari,M., Egawa,S., Ding,L. and
Matsuno,S.
TITLE Controlling tumor angiogenesis and metastasis of C26 murine colon
adenocarcinoma by a new matrix metalloproteinase inhibitor,
KB-R7785, in two tumor models
JOURNAL Cancer Res 59 (6), 1252-1258 (1999)
PUBMED 10096556
REFERENCE 8 (residues 1 to 914)
AUTHORS Bagnard,D., Lohrum,M., Uziel,D., Puschel,A.W. and Bolz,J.
TITLE Semaphorins act as attractive and repulsive guidance signals during
the development of cortical projections
JOURNAL Development 125 (24), 5043-5053 (1998)
PUBMED 9811588
REFERENCE 9 (residues 1 to 914)
AUTHORS Chedotal,A., Del Rio,J.A., Ruiz,M., He,Z., Borrell,V., de
Castro,F., Ezan,F., Goodman,C.S., Tessier-Lavigne,M., Sotelo,C. and
Soriano,E.
TITLE Semaphorins III and IV repel hippocampal axons via two distinct
receptors
JOURNAL Development 125 (21), 4313-4323 (1998)
PUBMED 9753685
REFERENCE 10 (residues 1 to 914)
AUTHORS Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
TITLE Neuropilin-2, a novel member of the neuropilin family, is a high
affinity receptor for the semaphorins Sema E and Sema IV but not
Sema III
JOURNAL Neuron 19 (3), 547-559 (1997)
PUBMED 9331348
REMARK Erratum:[Neuron 1997 Sep;19(3):559]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY320114.1, AK149643.1, AK153553.1 and AL671560.7.
On Oct 26, 2006 this sequence version replaced NP_035069.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns SAMN00849381,
SAMN00849382 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..914
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="1"
/map="1 31.35 cM"
Protein 1..914
/product="neuropilin-2 isoform 3 precursor"
/note="vascular endothelial cell growth factor 165
receptor 2"
/calculated_mol_wt=100146
sig_peptide 1..22
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
/calculated_mol_wt=2647
Region 28..141
/region_name="CUB"
/note="CUB domain; extracellular domain; present in
proteins mostly known to be involved in development; not
found in prokaryotes, plants and yeast; cd00041"
/db_xref="CDD:238001"
Site order(37,39,41,69,75,112,136,138,140..141)
/site_type="other"
/note="heterodimerization interface [polypeptide binding]"
/db_xref="CDD:238001"
Region 149..265
/region_name="CUB"
/note="CUB domain; extracellular domain; present in
proteins mostly known to be involved in development; not
found in prokaryotes, plants and yeast; cd00041"
/db_xref="CDD:238001"
Site 152
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O35375.2)"
Site order(157,159,161,188,193,237,261,263,265)
/site_type="other"
/note="heterodimerization interface [polypeptide binding]"
/db_xref="CDD:238001"
Site 157
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O35375.2)"
Region 280..426
/region_name="FA58C"
/note="Coagulation factor 5/8 C-terminal domain, discoidin
domain; Cell surface-attached carbohydrate-binding domain,
present in eukaryotes and assumed to have horizontally
transferred to eubacterial genomes; cd00057"
/db_xref="CDD:238014"
Region 298..317
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (O35375.2)"
Site order(319,347,356)
/site_type="other"
/note="sugar binding site [chemical binding]"
/db_xref="CDD:238014"
Region 438..591
/region_name="FA58C"
/note="Coagulation factor 5/8 C-terminal domain, discoidin
domain; Cell surface-attached carbohydrate-binding domain,
present in eukaryotes and assumed to have horizontally
transferred to eubacterial genomes; cd00057"
/db_xref="CDD:238014"
Site order(475,506,519)
/site_type="other"
/note="sugar binding site [chemical binding]"
/db_xref="CDD:238014"
Region 601..621
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (O35375.2)"
Site 629
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O35375.2)"
Region 641..794
/region_name="MAM"
/note="Domain in meprin, A5, receptor protein tyrosine
phosphatase mu (and others); smart00137"
/db_xref="CDD:214533"
Site 822
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (O35375.2)"
Region 833..914
/region_name="DUF3481"
/note="C-terminal domain of neuropilin glycoprotein;
pfam11980"
/db_xref="CDD:403259"
Site 848..872
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (O35375.2)"
CDS 1..914
/gene="Nrp2"
/gene_synonym="1110048P06Rik; Np-2; Np2; Npn-2; Npn2"
/coded_by="NM_010939.2:889..3633"
/note="isoform 3 precursor is encoded by transcript
variant 3"
/db_xref="CCDS:CCDS14995.1"
/db_xref="GeneID:18187"
/db_xref="MGI:MGI:1100492"
ORIGIN
1 mdmfpltwvf lalyfsghev rsqqdppcgg rlnskdagyi tspgypqdyp shqncewivy
61 apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsvl
121 yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil
181 akprmeiilq fltfdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpsklrs
241 stgilsltfh tdmavakdgf saryylihqe ppenfqcnvp lgmesgrian eqisasstfs
301 dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqkgyyvks
361 yklevstnge dwmvyrhgkn hkifqannda tevvlnklhm plltrfirir pqtwhlgial
421 rlelfgcrvt dapcsnmlgm lsgliadtqi sasstreylw spsaarlvss rsgwfprnpq
481 aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd
541 prtqqtklfe gnmhydtpdi rrfdpvpaqy vrvyperwsp agigmrlevl gcdwtdskpt
601 vetlgptvks eetttpypmd edatecgenc sfeddkdlql psgfncnfdf peetcgwvyd
661 hakwlrstwi ssanpndrtf pddknflklq sdgrregqyg rlisppvhlp rspvcmefqy
721 qamgghgval qvvreasqes kllwviredq gsewkhgrii lpsydmeyqi vfegvigkgr
781 sgeisiddir istdvplenc mepisafage dfkdeyegdw snsssstsga gdpssgkeks
841 wlytldpili tiiamsslgv llgatcagll lyctcsysgl ssrscttlen ynfelydglk
901 hkvkinhqkc csea
//