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neuropilin-2 isoform 3 precursor [Mus musculus]

NCBI Reference Sequence: NP_035069.2

Identical Proteins FASTA Graphics 

LOCUS       NP_035069                914 aa            linear   ROD 19-NOV-2024
DEFINITION  neuropilin-2 isoform 3 precursor [Mus musculus].
ACCESSION   NP_035069
VERSION     NP_035069.2
DBSOURCE    REFSEQ: accession NM_010939.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 914)
  AUTHORS   Vallecillo-Garcia,P., Kuhnlein,M.N., Orgeur,M., Hansmeier,N.R.,
            Kotsaris,G., Meisen,Z.G., Timmermann,B., Giesecke-Thiel,C.,
            Hagerling,R. and Stricker,S.
  TITLE     Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel
            formation
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39221968
REFERENCE   2  (residues 1 to 914)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 914)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 914)
  AUTHORS   Benwell,C.J., Johnson,R.T., Taylor,J.A.G.E., Lambert,J. and
            Robinson,S.D.
  TITLE     A proteomics approach to isolating neuropilin-dependent alpha5
            integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5
            integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells
  JOURNAL   Commun Biol 7 (1), 629 (2024)
   PUBMED   38789481
  REMARK    GeneRIF: A proteomics approach to isolating neuropilin-dependent
            alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic
            alpha5 integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 914)
  AUTHORS   Vosbeck,K., Forster,S., Mayr,T., Sahu,A., Haddouti,E.M.,
            Al-Adilee,O., Korber,R.M., Bisht,S., Muders,M.H., Nesic,S.,
            Buness,A., Kristiansen,G., Schildberg,F.A. and Gutgemann,I.
  TITLE     Neuropilin2 in Mesenchymal Stromal Cells as a Potential Novel
            Therapeutic Target in Myelofibrosis
  JOURNAL   Cancers (Basel) 16 (10), 1924 (2024)
   PUBMED   38792002
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 914)
  AUTHORS   Takahashi,T., Fournier,A., Nakamura,F., Wang,L.H., Murakami,Y.,
            Kalb,R.G., Fujisawa,H. and Strittmatter,S.M.
  TITLE     Plexin-neuropilin-1 complexes form functional semaphorin-3A
            receptors
  JOURNAL   Cell 99 (1), 59-69 (1999)
   PUBMED   10520994
REFERENCE   7  (residues 1 to 914)
  AUTHORS   Lozonschi,L., Sunamura,M., Kobari,M., Egawa,S., Ding,L. and
            Matsuno,S.
  TITLE     Controlling tumor angiogenesis and metastasis of C26 murine colon
            adenocarcinoma by a new matrix metalloproteinase inhibitor,
            KB-R7785, in two tumor models
  JOURNAL   Cancer Res 59 (6), 1252-1258 (1999)
   PUBMED   10096556
REFERENCE   8  (residues 1 to 914)
  AUTHORS   Bagnard,D., Lohrum,M., Uziel,D., Puschel,A.W. and Bolz,J.
  TITLE     Semaphorins act as attractive and repulsive guidance signals during
            the development of cortical projections
  JOURNAL   Development 125 (24), 5043-5053 (1998)
   PUBMED   9811588
REFERENCE   9  (residues 1 to 914)
  AUTHORS   Chedotal,A., Del Rio,J.A., Ruiz,M., He,Z., Borrell,V., de
            Castro,F., Ezan,F., Goodman,C.S., Tessier-Lavigne,M., Sotelo,C. and
            Soriano,E.
  TITLE     Semaphorins III and IV repel hippocampal axons via two distinct
            receptors
  JOURNAL   Development 125 (21), 4313-4323 (1998)
   PUBMED   9753685
REFERENCE   10 (residues 1 to 914)
  AUTHORS   Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY320114.1, AK149643.1, AK153553.1 and AL671560.7.
            
            On Oct 26, 2006 this sequence version replaced NP_035069.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 31.35 cM"
     Protein         1..914
                     /product="neuropilin-2 isoform 3 precursor"
                     /note="vascular endothelial cell growth factor 165
                     receptor 2"
                     /calculated_mol_wt=100146
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2647
     Region          28..141
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(37,39,41,69,75,112,136,138,140..141)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          149..265
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            152
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35375.2)"
     Site            order(157,159,161,188,193,237,261,263,265)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            157
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35375.2)"
     Region          280..426
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Region          298..317
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35375.2)"
     Site            order(319,347,356)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     Region          438..591
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Site            order(475,506,519)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     Region          601..621
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35375.2)"
     Site            629
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35375.2)"
     Region          641..794
                     /region_name="MAM"
                     /note="Domain in meprin, A5, receptor protein tyrosine
                     phosphatase mu (and others); smart00137"
                     /db_xref="CDD:214533"
     Site            822
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35375.2)"
     Region          833..914
                     /region_name="DUF3481"
                     /note="C-terminal domain of neuropilin glycoprotein;
                     pfam11980"
                     /db_xref="CDD:403259"
     Site            848..872
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35375.2)"
     CDS             1..914
                     /gene="Nrp2"
                     /gene_synonym="1110048P06Rik; Np-2; Np2; Npn-2; Npn2"
                     /coded_by="NM_010939.2:889..3633"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS14995.1"
                     /db_xref="GeneID:18187"
                     /db_xref="MGI:MGI:1100492"
ORIGIN      
        1 mdmfpltwvf lalyfsghev rsqqdppcgg rlnskdagyi tspgypqdyp shqncewivy
       61 apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsvl
      121 yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil
      181 akprmeiilq fltfdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpsklrs
      241 stgilsltfh tdmavakdgf saryylihqe ppenfqcnvp lgmesgrian eqisasstfs
      301 dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqkgyyvks
      361 yklevstnge dwmvyrhgkn hkifqannda tevvlnklhm plltrfirir pqtwhlgial
      421 rlelfgcrvt dapcsnmlgm lsgliadtqi sasstreylw spsaarlvss rsgwfprnpq
      481 aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd
      541 prtqqtklfe gnmhydtpdi rrfdpvpaqy vrvyperwsp agigmrlevl gcdwtdskpt
      601 vetlgptvks eetttpypmd edatecgenc sfeddkdlql psgfncnfdf peetcgwvyd
      661 hakwlrstwi ssanpndrtf pddknflklq sdgrregqyg rlisppvhlp rspvcmefqy
      721 qamgghgval qvvreasqes kllwviredq gsewkhgrii lpsydmeyqi vfegvigkgr
      781 sgeisiddir istdvplenc mepisafage dfkdeyegdw snsssstsga gdpssgkeks
      841 wlytldpili tiiamsslgv llgatcagll lyctcsysgl ssrscttlen ynfelydglk
      901 hkvkinhqkc csea
//
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