LOCUS NP_001292107 336 aa linear ROD 19-SEP-2024
DEFINITION mitochondrial calcium uniporter regulator 1 [Rattus norvegicus].
ACCESSION NP_001292107
VERSION NP_001292107.1
DBSOURCE REFSEQ: accession NM_001305178.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 336)
AUTHORS Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
Warscheid,B.
TITLE Quantitative high-confidence human mitochondrial proteome and its
dynamics in cellular context
JOURNAL Cell Metab 33 (12), 2464-2483 (2021)
PUBMED 34800366
REFERENCE 2 (residues 1 to 336)
AUTHORS Tomar,D., Dong,Z., Shanmughapriya,S., Koch,D.A., Thomas,T.,
Hoffman,N.E., Timbalia,S.A., Goldman,S.J., Breves,S.L.,
Corbally,D.P., Nemani,N., Fairweather,J.P., Cutri,A.R., Zhang,X.,
Song,J., Jana,F., Huang,J., Barrero,C., Rabinowitz,J.E.,
Luongo,T.S., Schumacher,S.M., Rockman,M.E., Dietrich,A., Merali,S.,
Caplan,J., Stathopulos,P., Ahima,R.S., Cheung,J.Y., Houser,S.R.,
Koch,W.J., Patel,V., Gohil,V.M., Elrod,J.W., Rajan,S. and Madesh,M.
TITLE MCUR1 Is a Scaffold Factor for the MCU Complex Function and
Promotes Mitochondrial Bioenergetics
JOURNAL Cell Rep 15 (8), 1673-1685 (2016)
PUBMED 27184846
REFERENCE 3 (residues 1 to 336)
AUTHORS Vais,H., Tanis,J.E., Muller,M., Payne,R., Mallilankaraman,K. and
Foskett,J.K.
TITLE MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium
Uniporter
JOURNAL Cell Metab 22 (4), 533-535 (2015)
PUBMED 26445506
REFERENCE 4 (residues 1 to 336)
AUTHORS Mallilankaraman,K., Cardenas,C., Doonan,P.J., Chandramoorthy,H.C.,
Irrinki,K.M., Golenar,T., Csordas,G., Madireddi,P., Yang,J.,
Muller,M., Miller,R., Kolesar,J.E., Molgo,J., Kaufman,B.,
Hajnoczky,G., Foskett,J.K. and Madesh,M.
TITLE MCUR1 is an essential component of mitochondrial Ca2+ uptake that
regulates cellular metabolism
JOURNAL Nat Cell Biol 14 (12), 1336-1343 (2012)
PUBMED 23178883
REMARK Erratum:[Nat Cell Biol. 2013 Jan;15(1):123]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000017.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments and orthologous data.
##Evidence-Data-START##
Transcript exon combination :: SRR26643292.57454.1,
SRR26643289.39638.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760383, SAMEA5760386
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
RefSeq Select criteria :: based on single
protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..336
/organism="Rattus norvegicus"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="17"
/map="17p14"
Protein 1..336
/product="mitochondrial calcium uniporter regulator 1"
/EC_number="1.1.1.41"
/note="coiled-coil domain-containing protein 90A,
mitochondrial; coiled-coil domain containing 90A"
/calculated_mol_wt=37420
Region 143..335
/region_name="CCDC90-like"
/note="Coiled-coil domain-containing protein 90-like;
pfam07798"
/db_xref="CDD:462268"
CDS 1..336
/gene="Mcur1"
/gene_synonym="Ccdc90a; RGD1307673"
/coded_by="NM_001305178.1:1..1011"
/db_xref="GeneID:291034"
/db_xref="RGD:1307673"
ORIGIN
1 mdsgslaaer pkrtpgrqrl lssgcgvpvr pgvstlpggr swlrprgrta rasrllllll
61 vpsprlaata prrtlaersr pglvipaaal gagrnalgrl rlgarrvaal vssrrelsls
121 archqleprk gnlptsvsrq lyfdthalvc lleangftiq qaeiivsalv kitetnmdii
181 ykdmvskmqq eitlqqiisk ianvkkdmii leksefsalr aenekiklel hqlkqqvmde
241 vtkvrtdtkl nfnleksrvk elyslnekkm lelrteivsl haqqdraltq tdrkieteva
301 glktmleahk ldtikylags vftcltvalg fyrlwi
//