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mitochondrial calcium uniporter regulator 1 [Rattus norvegicus]

NCBI Reference Sequence: NP_001292107.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001292107             336 aa            linear   ROD 19-SEP-2024
DEFINITION  mitochondrial calcium uniporter regulator 1 [Rattus norvegicus].
ACCESSION   NP_001292107
VERSION     NP_001292107.1
DBSOURCE    REFSEQ: accession NM_001305178.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 336)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 336)
  AUTHORS   Tomar,D., Dong,Z., Shanmughapriya,S., Koch,D.A., Thomas,T.,
            Hoffman,N.E., Timbalia,S.A., Goldman,S.J., Breves,S.L.,
            Corbally,D.P., Nemani,N., Fairweather,J.P., Cutri,A.R., Zhang,X.,
            Song,J., Jana,F., Huang,J., Barrero,C., Rabinowitz,J.E.,
            Luongo,T.S., Schumacher,S.M., Rockman,M.E., Dietrich,A., Merali,S.,
            Caplan,J., Stathopulos,P., Ahima,R.S., Cheung,J.Y., Houser,S.R.,
            Koch,W.J., Patel,V., Gohil,V.M., Elrod,J.W., Rajan,S. and Madesh,M.
  TITLE     MCUR1 Is a Scaffold Factor for the MCU Complex Function and
            Promotes Mitochondrial Bioenergetics
  JOURNAL   Cell Rep 15 (8), 1673-1685 (2016)
   PUBMED   27184846
REFERENCE   3  (residues 1 to 336)
  AUTHORS   Vais,H., Tanis,J.E., Muller,M., Payne,R., Mallilankaraman,K. and
            Foskett,J.K.
  TITLE     MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium
            Uniporter
  JOURNAL   Cell Metab 22 (4), 533-535 (2015)
   PUBMED   26445506
REFERENCE   4  (residues 1 to 336)
  AUTHORS   Mallilankaraman,K., Cardenas,C., Doonan,P.J., Chandramoorthy,H.C.,
            Irrinki,K.M., Golenar,T., Csordas,G., Madireddi,P., Yang,J.,
            Muller,M., Miller,R., Kolesar,J.E., Molgo,J., Kaufman,B.,
            Hajnoczky,G., Foskett,J.K. and Madesh,M.
  TITLE     MCUR1 is an essential component of mitochondrial Ca2+ uptake that
            regulates cellular metabolism
  JOURNAL   Nat Cell Biol 14 (12), 1336-1343 (2012)
   PUBMED   23178883
  REMARK    Erratum:[Nat Cell Biol. 2013 Jan;15(1):123]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.57454.1,
                                           SRR26643289.39638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     Protein         1..336
                     /product="mitochondrial calcium uniporter regulator 1"
                     /EC_number="1.1.1.41"
                     /note="coiled-coil domain-containing protein 90A,
                     mitochondrial; coiled-coil domain containing 90A"
                     /calculated_mol_wt=37420
     Region          143..335
                     /region_name="CCDC90-like"
                     /note="Coiled-coil domain-containing protein 90-like;
                     pfam07798"
                     /db_xref="CDD:462268"
     CDS             1..336
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /coded_by="NM_001305178.1:1..1011"
                     /db_xref="GeneID:291034"
                     /db_xref="RGD:1307673"
ORIGIN      
        1 mdsgslaaer pkrtpgrqrl lssgcgvpvr pgvstlpggr swlrprgrta rasrllllll
       61 vpsprlaata prrtlaersr pglvipaaal gagrnalgrl rlgarrvaal vssrrelsls
      121 archqleprk gnlptsvsrq lyfdthalvc lleangftiq qaeiivsalv kitetnmdii
      181 ykdmvskmqq eitlqqiisk ianvkkdmii leksefsalr aenekiklel hqlkqqvmde
      241 vtkvrtdtkl nfnleksrvk elyslnekkm lelrteivsl haqqdraltq tdrkieteva
      301 glktmleahk ldtikylags vftcltvalg fyrlwi
//
Feature
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the Mcur1 gene (NM_001305178.1).

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