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CREB binding protein b isoform X1 [Danio rerio]

NCBI Reference Sequence: XP_021328563.1

Identical Proteins FASTA Graphics 

LOCUS       XP_021328563            2420 aa            linear   VRT 08-SEP-2024
DEFINITION  CREB binding protein b isoform X1 [Danio rerio].
ACCESSION   XP_021328563
VERSION     XP_021328563.1
DBLINK      BioProject: PRJNA13922
DBSOURCE    REFSEQ: accession XM_021472888.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_007114.7) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_000002035.6-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/15/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2420
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
     Protein         1..2420
                     /product="CREB binding protein b isoform X1"
                     /calculated_mol_wt=266087
     Region          338..405
                     /region_name="zf-TAZ"
                     /note="TAZ zinc finger; pfam02135"
                     /db_xref="CDD:460457"
     Region          550..630
                     /region_name="KIX"
                     /note="KIX domain; pfam02172"
                     /db_xref="CDD:366953"
     Region          637..>906
                     /region_name="Med15"
                     /note="ARC105 or Med15 subunit of Mediator complex
                     non-fungal; pfam09606"
                     /db_xref="CDD:312941"
     Region          <857..>980
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     Region          1021..1128
                     /region_name="Bromo_cbp_like"
                     /note="Bromodomain, cbp_like subfamily. Cbp (CREB binding
                     protein or CREBBP) is an acetyltransferase acting on
                     histone, which gives a specific tag for transcriptional
                     activation and also acetylates non-histone proteins.
                     CREBBP binds specifically to...; cd05495"
                     /db_xref="CDD:99927"
     Site            order(1049,1056,1059,1098,1102,1108)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99927"
     Region          1140..1212
                     /region_name="RING_CBP-p300"
                     /note="atypical RING domain found in CREB-binding protein
                     and p300 histone acetyltransferases; cd15802"
                     /db_xref="CDD:276805"
     Site            order(1140,1143..1144,1210,1212)
                     /site_type="other"
                     /note="HAT interface [polypeptide binding]"
                     /db_xref="CDD:276805"
     Region          1213..1247
                     /region_name="PHD_CBP"
                     /note="PHD finger found in CREB-binding protein (CBP);
                     cd15647"
                     /db_xref="CDD:277117"
     Site            order(1213..1217,1221,1240)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277117"
     Region          1276..1583
                     /region_name="HAT_KAT11"
                     /note="Histone acetylation protein; pfam08214"
                     /db_xref="CDD:400497"
     Region          1639..1679
                     /region_name="ZZ_CBP"
                     /note="Zinc finger, ZZ type. Zinc finger present in
                     CBP/p300 and related proteins. The ZZ motif coordinates
                     two zinc ions and most likely participates in ligand
                     binding or molecular scaffolding. CREB-binding protein
                     (CBP) is a large multidomain protein that...; cd02337"
                     /db_xref="CDD:239077"
     Site            order(1641,1644,1654,1657,1663,1666,1672,1674)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239077"
     Site            order(1641,1644,1663,1666)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239077"
     Site            order(1642,1651,1653,1659,1661)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239077"
     Site            order(1652,1667,1676,1679)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239077"
     Site            order(1654,1657,1672,1674)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239077"
     Region          1706..1774
                     /region_name="zf-TAZ"
                     /note="TAZ zinc finger; pfam02135"
                     /db_xref="CDD:460457"
     Region          2013..2114
                     /region_name="Creb_binding"
                     /note="Creb binding; pfam09030"
                     /db_xref="CDD:462659"
     CDS             1..2420
                     /gene="crebbpb"
                     /gene_synonym="CBP-A; gb:dq017638; im:7150488;
                     si:ch211-121i18.1; wu:fp53a03; Zfcbp"
                     /coded_by="XM_021472888.2:739..8001"
                     /db_xref="GeneID:567111"
                     /db_xref="ZFIN:ZDB-GENE-050302-102"
ORIGIN      
        1 madnlldmgp saakrpklns palsssdtpd fvslfdlend lpdelipngd lglmsmpsng
       61 dggvgsrmgg nvpdaaakhk qlsqllqags gsglggnlsp qsgmggqlga lgkspmgqgs
      121 pghqtqapkp vgtptgqgnn spgmgmntgf npamlnnnnq ahglmgqnmt pqgqmmngvm
      181 gpagrgrtap gmqyqgqgmq gapvgagggq gvgvsgsvla etltqgapqm gahnainqqa
      241 gnmnkmglat angpfgqqyv qgsvqqmsna glnaqmqnka alpnslqptl kgassvpnll
      301 qqqvpsvgmv pgqgvsagpt adpekrkliq qqlvlllhah kcqrreqang evracalphc
      361 rtmknvlnhm thcqagkscq vahcassrqi ishwknctrh dcpvclplkn asdkrnqqpm
      421 lsspnpgmqs plgqvgtsqp aapaissgth idpssmqray aalglpygnq paaqtqvagq
      481 qptqtqqmrs maalgsnqmn iggngmadqt nlhtdsslps slssnqmmpd gsnmggagnl
      541 ptaaplsmpg mkkpwhehvt qdlrnhlvhk lvqaifptpd paalkdrrme nlvayarkve
      601 gdmyesansr deyyhflaek iykiqkelee krksrlskpq mgaqgpqqpg lpqpnpmgpa
      661 qairppngpv smsnvpnqlm armqvpqgmg qfnpvtmqnv qmsqsqvgap raaspmthnp
      721 qmgmgnvppm vmspsrmpqa qammgghann mvgqtpnqnq fmnqtpfpas aggmnvnvnl
      781 aqqsgqtvqq qqqqnanltl navgslgpps alcstpppps astpsaaasl qslqtqpstp
      841 asvgghvtpt hipsglprpp svlgsspaps qphtplqsqp eppmqmqqpt svqaqqpstp
      901 lsqmapsvdn rvptpasvae thsqqalpdy paaepkiehq edeqevesgk krpdikmede
      961 dvkppqvkeq petvepkqep metedkkpet ktepkeeevs stnsstpanq saqsrkkifk
     1021 peelrqalmp tlealyrqdp eslpfrqpvd pnllgipdyf divknpidls tikrkldtgq
     1081 yqepwqyvdd iwlmfnnawl ynrktsrvyk ycsklaevfe qeidpvmqgl gyccgrkyef
     1141 spqtlccygk qlctisrdgt yysyqnryhf cekcfneiqg dsvtlgddpt qsqtmiskeq
     1201 fekkkndtld sepfveckdc grkmhqicvl hydviwpsgf icdnclkksg ksrkenkfsa
     1261 kklqctrlgs yiedrvnkyl krqnhpeage vfvrvvassd ktvevkpgmk srfvdsgems
     1321 esfpyrtkal fafeeidgvd vcffgmhvqe ygsdcpfpnt rrvyisylds ihffkprllr
     1381 tavyheilig yleyvkklgy vtghiwacpp segddyifhc hppdqkipkp krlqewyrkm
     1441 ldkafaerii hdykdifkqa tedrltsaye lpyfegdfwp nvleesikel eqeeeerkke
     1501 entassette gaqadsknak kknnkktnkn kssvsrankk kpgmpnvand lsqklyatme
     1561 khkevffvih lhagpvvntl ppimdpdpll tcdlmdgrda fltlardkhw efsslrrckw
     1621 stmcmlvelh nqgqdrfvyt cneckhhvet rwhctvcedf dlcincynsk ghehqmvkwg
     1681 lgldddsnnq ggeankspqe srrlsiqrci qslvhacqcr nancslpscq kmkrvvqhtk
     1741 gckrktnggc pvckqlialc cyhakhcqen kcpvpfclni khklrqqqiq qrlqqaqmmr
     1801 rrmalmqgrg mppslpsptt sggpgtpnsq qlqqpntpqt sqalanqpqq thpnvaamvq
     1861 afpnqpptpg sqgkpgpqss plpqqqsplp mppqqqpqps pqqqalkvak qiemmtkvkq
     1921 qqqqqqqqqq qqqqqqqqqq qqdyrmsmng mpmnqprmmt smqmmgprgp qmvqnmqqgq
     1981 wapgmamqnp qgpppqqvpq qqmamaqqqs qvaqtpqqaq miqralmqqq qqqqqqprqi
     2041 qavmppqqvq pqapqqqgmq qrgvtsnitp galqdllrtl kspsspqqqq qvlnilksnp
     2101 hlmaafikqr takyqanqpq qqqnpqamla sqqgmqnmaa mqpgsvqrpv mppqqqpqpq
     2161 paatqamaal gsqgqmmnaa hngnqqlfrr qllrqmqqqq qhqqqqgamp pgqgrfpqpq
     2221 gaasysqirv qqqmamqgga gpmgqmppma qmgqpgmgld aqqqqnlmqq rmlqqqqqqq
     2281 qqmmkqqmgs paqaasmspq phmlggqpqg ahmpgqaman algnqvrspa pvqsprppsq
     2341 qpphsspspr mqpqpsplhp gsshpslagp mpgpmdqahm ctaeqsamlp qlntpnrggl
     2401 tndlnmdttg dtlekfvegl
//
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