Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production.
Weinreb JT, Ghazale N, Pradhan K, Gupta V, Potts KS, Tricomi B, Daniels NJ, Padgett RA, De Oliveira S, Verma A, et al. Dev Cell. 2021 Mar 8; 56(5):627-640.e5. Epub 2021 Mar 1.