1-phosphatidylinositol 3-phosphate 5-kinase isoform X8 [Homo sapiens]

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Show in Genome Data Viewer
Opens the Genome Data Viewer, NCBI's genome browser, at the genomic location at which this sequence is annotated. View this sequence in the context of other features annotated at the same location and browse to other genome regions.

Coxiella burnetii effector CvpE maintains biogenesis of Coxiella-containing vacuoles by suppressing lysosome tubulation through binding PI(3)P and perturbing PIKfyve activity on lysosomes. [Virulence. 2024]
Coxiella burnetii effector CvpE maintains biogenesis of Coxiella-containing vacuoles by suppressing lysosome tubulation through binding PI(3)P and perturbing PIKfyve activity on lysosomes.
Zhao M, Zhang S, Wan W, Zhou C, Li N, Cheng R, Yu Y, Ouyang X, Zhou D, Jiao J, et al. Virulence. 2024 Dec; 15(1):2350893. Epub 2024 May 9.
Stress-induced microautophagy is coordinated with lysosome biogenesis and regulated by PIKfyve. [Mol Biol Cell. 2024]
Stress-induced microautophagy is coordinated with lysosome biogenesis and regulated by PIKfyve.
Klein AD, Petruzzi KL, Lee C, Overholtzer M. Mol Biol Cell. 2024 May 1; 35(5):ar70. Epub 2024 Mar 27.
Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer. [Nat Cancer. 2021]
Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer.
Qiao Y, Choi JE, Tien JC, Simko SA, Rajendiran T, Vo JN, Delekta AD, Wang L, Xiao L, Hodge NB, et al. Nat Cancer. 2021 Sep; 2:978-993. Epub 2021 Aug 2.

RefSeq genomic sequence
See the genomic reference sequence for the PIKFYVE gene (NG_021188.2).
RefSeq mRNA
See reference mRNA sequence for the PIKFYVE gene (XM_011510784.3).
RefSeq protein isoforms
See 77 reference sequence protein isoforms for the PIKFYVE gene.

BioProject
Proteins related to BioProjects
Nucleotide
Nucleotide sequence from coding region
Taxonomy
Taxonomy sequences associated with protein record
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Encoding mRNA
Link from protein to encoding mRNA
Gene
Link to related Genes
Genome
Genome record encoding protein sequence
PubMed (RefSeq)
Link to RefSeq PubMed articles
PubMed (Weighted)
Links to pubmed
SNP
Related SNPs

Your browsing activity is empty.

Activity recording is turned off.

Protein