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MULTISPECIES: MATE family efflux transporter [Clostridiaceae]

NCBI Reference Sequence: WP_069988498.1

Identical Proteins FASTA Graphics 

LOCUS       WP_069988498             459 aa            linear   BCT 01-JAN-2025
DEFINITION  MULTISPECIES: MATE family efflux transporter [Clostridiaceae].
ACCESSION   WP_069988498
VERSION     WP_069988498.1
KEYWORDS    RefSeq.
SOURCE      Clostridiaceae
  ORGANISM  Clostridiaceae
            Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales.
REFERENCE   1  (residues 1 to 459)
  AUTHORS   Claxton,D.P., Jagessar,K.L. and Mchaourab,H.S.
  TITLE     Principles of Alternating Access in Multidrug and Toxin Extrusion
            (MATE) Transporters
  JOURNAL   J Mol Biol 433 (16), 166959 (2021)
   PUBMED   33774036
REFERENCE   2  (residues 1 to 459)
  AUTHORS   Kusakizako,T., Miyauchi,H., Ishitani,R. and Nureki,O.
  TITLE     Structural biology of the multidrug and toxic compound extrusion
            superfamily transporters
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (12), 183154 (2020)
   PUBMED   31866287
REFERENCE   3  (residues 1 to 459)
  AUTHORS   Radchenko,M., Symersky,J., Nie,R. and Lu,M.
  TITLE     Structural basis for the blockade of MATE multidrug efflux pumps
  JOURNAL   Nat Commun 6, 7995 (2015)
   PUBMED   26246409
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 459)
  AUTHORS   Kaatz,G.W., DeMarco,C.E. and Seo,S.M.
  TITLE     MepR, a repressor of the Staphylococcus aureus MATE family
            multidrug efflux pump MepA, is a substrate-responsive regulatory
            protein
  JOURNAL   Antimicrob Agents Chemother 50 (4), 1276-1281 (2006)
   PUBMED   16569840
REFERENCE   5  (residues 1 to 459)
  AUTHORS   Putman,M., van Veen,H.W. and Konings,W.N.
  TITLE     Molecular properties of bacterial multidrug transporters
  JOURNAL   Microbiol Mol Biol Rev 64 (4), 672-693 (2000)
   PUBMED   11104814
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10192113
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Clostridiaceae"
                     /db_xref="taxon:31979"
     Protein         1..459
                     /product="MATE family efflux transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]; GO:0042910 - xenobiotic transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]; GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /calculated_mol_wt=50075
     Region          12..442
                     /region_name="MATE_MepA_like"
                     /note="Subfamily of the multidrug and toxic compound
                     extrusion (MATE)-like proteins similar to Streptococcus
                     aureus MepA; cd13143"
                     /db_xref="CDD:240548"
ORIGIN      
        1 mekekdflgk epvnkllwkl alptvtaqii nmlynivdri yighipeegt laltgvgvcm
       61 plimivtafa alvsnggapr asiymgkgek elaektlgnc fslqiiisll lttvlliwnr
      121 dflmafgasn ntieygvsym niyaigtifv qltlgmnafi taqgfaktgm lsvligavcn
      181 ivldpififg fgmgvrgaal atilsqavsc iwvlnflfgk rtflkirkrh lmlkskiilp
      241 slalglavfi mqasesvisi cfnssllryg gdiavgamti ltsvmqfaml plqglgqgaq
      301 piisynygar nvdrvksafr lllkaslfys cllwalillf pqvfaalfts dpalleftkt
      361 alriytacll lfgiqmacqm tfnslgnaka silvavmrkf illipliyll plifssnktt
      421 avylaepvad flavsftail fifqfkkala emsnspkqn
//
Feature
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