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NCBI Reference Sequence: WP_069988498.1
Identical Proteins FASTA Graphics
Download a prokaryotic data package including protein sequence and gene sequence for all annotated locations for this protein as a zip archive.
LOCUS WP_069988498 459 aa linear BCT 01-JAN-2025 DEFINITION MULTISPECIES: MATE family efflux transporter [Clostridiaceae]. ACCESSION WP_069988498 VERSION WP_069988498.1 KEYWORDS RefSeq. SOURCE Clostridiaceae ORGANISM Clostridiaceae Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales. REFERENCE 1 (residues 1 to 459) AUTHORS Claxton,D.P., Jagessar,K.L. and Mchaourab,H.S. TITLE Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters JOURNAL J Mol Biol 433 (16), 166959 (2021) PUBMED 33774036 REFERENCE 2 (residues 1 to 459) AUTHORS Kusakizako,T., Miyauchi,H., Ishitani,R. and Nureki,O. TITLE Structural biology of the multidrug and toxic compound extrusion superfamily transporters JOURNAL Biochim Biophys Acta Biomembr 1862 (12), 183154 (2020) PUBMED 31866287 REFERENCE 3 (residues 1 to 459) AUTHORS Radchenko,M., Symersky,J., Nie,R. and Lu,M. TITLE Structural basis for the blockade of MATE multidrug efflux pumps JOURNAL Nat Commun 6, 7995 (2015) PUBMED 26246409 REMARK Publication Status: Online-Only REFERENCE 4 (residues 1 to 459) AUTHORS Kaatz,G.W., DeMarco,C.E. and Seo,S.M. TITLE MepR, a repressor of the Staphylococcus aureus MATE family multidrug efflux pump MepA, is a substrate-responsive regulatory protein JOURNAL Antimicrob Agents Chemother 50 (4), 1276-1281 (2006) PUBMED 16569840 REFERENCE 5 (residues 1 to 459) AUTHORS Putman,M., van Veen,H.W. and Konings,W.N. TITLE Molecular properties of bacterial multidrug transporters JOURNAL Microbiol Mol Biol Rev 64 (4), 672-693 (2000) PUBMED 11104814 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 10192113 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..459 /organism="Clostridiaceae" /db_xref="taxon:31979" Protein 1..459 /product="MATE family efflux transporter" /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0015297 - antiporter activity [Evidence IEA]; GO:0042910 - xenobiotic transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]; GO:0006855 - xenobiotic transmembrane transport [Evidence IEA]" /calculated_mol_wt=50075 Region 12..442 /region_name="MATE_MepA_like" /note="Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; cd13143" /db_xref="CDD:240548" ORIGIN 1 mekekdflgk epvnkllwkl alptvtaqii nmlynivdri yighipeegt laltgvgvcm 61 plimivtafa alvsnggapr asiymgkgek elaektlgnc fslqiiisll lttvlliwnr 121 dflmafgasn ntieygvsym niyaigtifv qltlgmnafi taqgfaktgm lsvligavcn 181 ivldpififg fgmgvrgaal atilsqavsc iwvlnflfgk rtflkirkrh lmlkskiilp 241 slalglavfi mqasesvisi cfnssllryg gdiavgamti ltsvmqfaml plqglgqgaq 301 piisynygar nvdrvksafr lllkaslfys cllwalillf pqvfaalfts dpalleftkt 361 alriytacll lfgiqmacqm tfnslgnaka silvavmrkf illipliyll plifssnktt 421 avylaepvad flavsftail fifqfkkala emsnspkqn //
Whole sequence Selected region from: to:
Conserved Domains
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