MULTISPECIES: DNA topoisomerase IV subunit B [Phocaeicola]

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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. [Bioorg Med Chem Lett. 2013]
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Tari LW, Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, et al. Bioorg Med Chem Lett. 2013 Mar 1; 23(5):1529-36. Epub 2012 Dec 5.
DNA topoisomerases: structure, function, and mechanism. [Annu Rev Biochem. 2001]
DNA topoisomerases: structure, function, and mechanism.
Champoux JJ. Annu Rev Biochem. 2001; 70:369-413.

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