U.S. flag

An official website of the United States government

  • This record is a non-redundant protein sequence. Please read more here.

MULTISPECIES: type I restriction endonuclease subunit R [Enterobacterales]

NCBI Reference Sequence: WP_004152343.1

Identical Proteins FASTA Graphics 

LOCUS       WP_004152343            1085 aa            linear   BCT 01-JAN-2025
DEFINITION  MULTISPECIES: type I restriction endonuclease subunit R
            [Enterobacterales].
ACCESSION   WP_004152343
VERSION     WP_004152343.1
KEYWORDS    RefSeq.
SOURCE      Enterobacterales
  ORGANISM  Enterobacterales
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria.
REFERENCE   1  (residues 1 to 1085)
  AUTHORS   Gao,Y., Cao,D., Zhu,J., Feng,H., Luo,X., Liu,S., Yan,X.X., Zhang,X.
            and Gao,P.
  TITLE     Structural insights into assembly, operation and inhibition of a
            type I restriction-modification system
  JOURNAL   Nat Microbiol 5 (9), 1107-1118 (2020)
   PUBMED   32483229
REFERENCE   2  (residues 1 to 1085)
  AUTHORS   Loenen,W.A., Dryden,D.T., Raleigh,E.A. and Wilson,G.G.
  TITLE     Type I restriction enzymes and their relatives
  JOURNAL   Nucleic Acids Res 42 (1), 20-44 (2014)
   PUBMED   24068554
REFERENCE   3  (residues 1 to 1085)
  AUTHORS   Gustafson,E.A. and Wessel,G.M.
  TITLE     DEAD-box helicases: posttranslational regulation and function
  JOURNAL   Biochem Biophys Res Commun 395 (1), 1-6 (2010)
   PUBMED   20206133
REFERENCE   4  (residues 1 to 1085)
  AUTHORS   Roberts,R.J., Belfort,M., Bestor,T., Bhagwat,A.S., Bickle,T.A.,
            Bitinaite,J., Blumenthal,R.M., Degtyarev,S.Kh., Dryden,D.T.,
            Dybvig,K., Firman,K., Gromova,E.S., Gumport,R.I., Halford,S.E.,
            Hattman,S., Heitman,J., Hornby,D.P., Janulaitis,A., Jeltsch,A.,
            Josephsen,J., Kiss,A., Klaenhammer,T.R., Kobayashi,I., Kong,H.,
            Kruger,D.H., Lacks,S., Marinus,M.G., Miyahara,M., Morgan,R.D.,
            Murray,N.E., Nagaraja,V., Piekarowicz,A., Pingoud,A., Raleigh,E.,
            Rao,D.N., Reich,N., Repin,V.E., Selker,E.U., Shaw,P.C., Stein,D.C.,
            Stoddard,B.L., Szybalski,W., Trautner,T.A., Van Etten,J.L.,
            Vitor,J.M., Wilson,G.G. and Xu,S.Y.
  TITLE     A nomenclature for restriction enzymes, DNA methyltransferases,
            homing endonucleases and their genes
  JOURNAL   Nucleic Acids Res 31 (7), 1805-1812 (2003)
   PUBMED   12654995
REFERENCE   5  (residues 1 to 1085)
  AUTHORS   Piekarowicz,A., Klyz,A., Kwiatek,A. and Stein,D.C.
  TITLE     Analysis of type I restriction modification systems in the
            Neisseriaceae: genetic organization and properties of the gene
            products
  JOURNAL   Mol Microbiol 41 (5), 1199-1210 (2001)
   PUBMED   11555298
REFERENCE   6  (residues 1 to 1085)
  AUTHORS   Makovets,S., Doronina,V.A. and Murray,N.E.
  TITLE     Regulation of endonuclease activity by proteolysis prevents
            breakage of unmodified bacterial chromosomes by type I restriction
            enzymes
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9757-9762 (1999)
   PUBMED   10449767
REFERENCE   7  (residues 1 to 1085)
  AUTHORS   Murray,N.E., Daniel,A.S., Cowan,G.M. and Sharp,P.M.
  TITLE     Conservation of motifs within the unusually variable polypeptide
            sequences of type I restriction and modification enzymes
  JOURNAL   Mol Microbiol 9 (1), 133-143 (1993)
   PUBMED   8412658
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11427405
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1085
                     /organism="Enterobacterales"
                     /db_xref="taxon:91347"
     Protein         1..1085
                     /product="type I restriction endonuclease subunit R"
                     /EC_number="3.1.21.3"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA];
                     GO:0003677 - DNA binding [Evidence IEA]; GO:0004386 -
                     helicase activity [Evidence IEA]; GO:0009035 - type I
                     site-specific deoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /calculated_mol_wt=121732
     Region          3..923
                     /region_name="COG0610"
                     /note="Type I site-specific restriction-modification
                     system, R (restriction) subunit and related helicases ...
                     [Defense mechanisms]"
                     /db_xref="CDD:440375"
ORIGIN      
        1 mqsaahqekh fqqyiidrlv eqgwklgdsk fydteravyp edleswikts gqqekwdkle
       61 rlngaktlev lmdrldkale kqgtmqvlrq gfsiagcgli emteaapedk rnaavieryq
      121 anilrvvpel kyhparefai dlvlfinglp vatvelktdf tqsceaamdq yrndrlpyda
      181 ktkrrepllt fkrgavvhfa msdseimmat kldgentffl pfnkgrkdes gtvhagnppg
      241 eikadgtqey pvayfweavc qpdawlrifh sfvyvekkdv vdiqgnwskk etlifprfhq
      301 wtavnqmltd arengagmty lcdhsagsgk tstiswtahd lvklredngd svfnsviivt
      361 drnvldgqlq davkqidhqf gviaaidrqk sskskskqls eallsgtpiv vvtiqtfpya
      421 meaiitdkal kgknfaviid eahnsqtgst aaklqaalgm sgqgkmstmt vdelleqlqk
      481 srarpdnisy faftgtpkhs tlmlfgrptd psqpasndnp pqafhlytmr qaieekfild
      541 vlkgyvpykt afnlskqled skrvsgkaak ralaqwmslh ptnvtqkvqf ivehftknva
      601 hrldgkakam vvtssraaai rykkafdryi eqhseygfih slvafsgkmt gkqvmhqdds
      661 efkddvfivd eneefteqsm npdvqgqdlr fafdrpeyrv mlvadkfqtg fdqpklvamy
      721 vdkkianhve ivqtfsrlnr tapgkdevfi idfvndpenv rqafttydkg ahidevqdln
      781 vvyeikerld ehglydekdl aafkearfkt irdithtksp qhkalyaata gatalyndkm
      841 kmlrdgmatw eaafekarak gdeagmksad hhqdeyaeqi kaligfksdl grfcrtysyi
      901 aqlidfgdpe lenfaafakl lqkrlqheap etvdltglvl tgfdinarsd naedegetpv
      961 lqpvgagggg vagdkpkfvk eiierlnslf geatpiqdqv afvnqifsia gesdvvmaqv
     1021 esntreqamk gnlpgavqqa vvralsshqk latqvlksdr qgmtalvdmv ydllregkdi
     1081 dlgmd
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Protein clusters for WP_004152343.1

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.