MULTISPECIES: Rv2466c family mycothiol-dependent reductase [Mycobacter - Protein

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Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. [ACS Chem Biol. 2014]
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
Albesa-Jové D, Chiarelli LR, Makarov V, Pasca MR, Urresti S, Mori G, Salina E, Vocat A, Comino N, Mohorko E, et al. ACS Chem Biol. 2014 Jul 18; 9(7):1567-75. Epub 2014 Jun 13.
The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053. [J Biol Chem. 2015]
The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.
Albesa-Jové D, Comino N, Tersa M, Mohorko E, Urresti S, Dainese E, Chiarelli LR, Pasca MR, Manganelli R, Makarov V, et al. J Biol Chem. 2015 Dec 25; 290(52):31077-89. Epub 2015 Nov 6.
The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis. [J Biol Chem. 2017]
The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis.
Rosado LA, Wahni K, Degiacomi G, Pedre B, Young D, de la Rubia AG, Boldrin F, Martens E, Marcos-Pascual L, Sancho-Vaello E, et al. J Biol Chem. 2017 Aug 11; 292(32):13097-13110. Epub 2017 Jun 15.

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