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RecName: Full=Regulatory protein NPR2; AltName: Full=BTB/POZ domain-containing protein NPR2

UniProtKB/Swiss-Prot: Q9SZI3.1

Identical Proteins FASTA Graphics 

LOCUS       NPR2_ARATH               600 aa            linear   PLN 27-NOV-2024
DEFINITION  RecName: Full=Regulatory protein NPR2; AltName: Full=BTB/POZ
            domain-containing protein NPR2.
ACCESSION   Q9SZI3
VERSION     Q9SZI3.1
DBSOURCE    UniProtKB: locus NPR2_ARATH, accession Q9SZI3;
            class: standard.
            created: May 3, 2011.
            sequence updated: May 1, 2000.
            annotation updated: Nov 27, 2024.
            xrefs: AL049483.1, CAB39677.1, AL161564.2, CAB79467.1, CP002687.1,
            AEE85160.1, T04267, NP_194342.1
            xrefs (non-sequence databases): AlphaFoldDB:Q9SZI3, SMR:Q9SZI3,
            DIP:DIP-59899N, IntAct:Q9SZI3, STRING:3702.Q9SZI3,
            PaxDb:3702-AT4G26120.1, EnsemblPlants:AT4G26120.1,
            EnsemblPlants:AT4G26120.1, EnsemblPlants:AT4G26120, GeneID:828718,
            Gramene:AT4G26120.1, KEGG:ath:AT4G26120, Araport:AT4G26120,
            TAIR:AT4G26120, eggNOG:KOG0504, HOGENOM:CLU_034895_1_0_1,
            InParanoid:Q9SZI3, OMA:NICGETY, PhylomeDB:Q9SZI3,
            UniPathway:UPA00143, PRO:PR:Q9SZI3, Proteomes:UP000006548,
            ExpressionAtlas:Q9SZI3, GO:0005737, GO:0016604, GO:0046872,
            GO:0042742, GO:0045087, GO:0016567, GO:0031347, GO:2000022,
            GO:2000031, GO:0009862, CDD:cd18310, FunFam:1.25.40.20:FF:000239,
            FunFam:3.30.710.10:FF:000192, Gene3D:1.25.40.20,
            InterPro:IPR002110, InterPro:IPR036770, InterPro:IPR000210,
            InterPro:IPR044292, InterPro:IPR021094, InterPro:IPR024228,
            InterPro:IPR011333, PANTHER:PTHR46475:SF1, PANTHER:PTHR46475,
            Pfam:PF12796, Pfam:PF00651, Pfam:PF11900, Pfam:PF12313,
            SMART:SM00248, SMART:SM00225, SUPFAM:SSF48403, SUPFAM:SSF54695,
            PROSITE:PS50297, PROSITE:PS50088, PROSITE:PS50097, PROSITE:PS52046
KEYWORDS    ANK repeat; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein;
            Plant defense; Reference proteome; Repeat; S-nitrosylation; Ubl
            conjugation pathway; Zinc; Zinc-finger.
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (residues 1 to 600)
  AUTHORS   Mayer,K., Schuller,C., Wambutt,R., Murphy,G., Volckaert,G.,
            Pohl,T., Dusterhoft,A., Stiekema,W., Entian,K.D., Terryn,N.,
            Harris,B., Ansorge,W., Brandt,P., Grivell,L., Rieger,M.,
            Weichselgartner,M., de Simone,V., Obermaier,B., Mache,R.,
            Muller,M., Kreis,M., Delseny,M., Puigdomenech,P., Watson,M.,
            Schmidtheini,T., Reichert,B., Portatelle,D., Perez-Alonso,M.,
            Boutry,M., Bancroft,I., Vos,P., Hoheisel,J., Zimmermann,W.,
            Wedler,H., Ridley,P., Langham,S.A., McCullagh,B., Bilham,L.,
            Robben,J., Van der Schueren,J., Grymonprez,B., Chuang,Y.J.,
            Vandenbussche,F., Braeken,M., Weltjens,I., Voet,M., Bastiaens,I.,
            Aert,R., Defoor,E., Weitzenegger,T., Bothe,G., Ramsperger,U.,
            Hilbert,H., Braun,M., Holzer,E., Brandt,A., Peters,S., van
            Staveren,M., Dirske,W., Mooijman,P., Klein Lankhorst,R., Rose,M.,
            Hauf,J., Kotter,P., Berneiser,S., Hempel,S., Feldpausch,M.,
            Lamberth,S., Van den Daele,H., De Keyser,A., Buysshaert,C.,
            Gielen,J., Villarroel,R., De Clercq,R., Van Montagu,M., Rogers,J.,
            Cronin,A., Quail,M., Bray-Allen,S., Clark,L., Doggett,J., Hall,S.,
            Kay,M., Lennard,N., McLay,K., Mayes,R., Pettett,A.,
            Rajandream,M.A., Lyne,M., Benes,V., Rechmann,S., Borkova,D.,
            Blocker,H., Scharfe,M., Grimm,M., Lohnert,T.H., Dose,S., de
            Haan,M., Maarse,A., Schafer,M., Muller-Auer,S., Gabel,C., Fuchs,M.,
            Fartmann,B., Granderath,K., Dauner,D., Herzl,A., Neumann,S.,
            Argiriou,A., Vitale,D., Liguori,R., Piravandi,E., Massenet,O.,
            Quigley,F., Clabauld,G., Mundlein,A., Felber,R., Schnabl,S.,
            Hiller,R., Schmidt,W., Lecharny,A., Aubourg,S., Chefdor,F.,
            Cooke,R., Berger,C., Montfort,A., Casacuberta,E., Gibbons,T.,
            Weber,N., Vandenbol,M., Bargues,M., Terol,J., Torres,A.,
            Perez-Perez,A., Purnelle,B., Bent,E., Johnson,S., Tacon,D.,
            Jesse,T., Heijnen,L., Schwarz,S., Scholler,P., Heber,S., Francs,P.,
            Bielke,C., Frishman,D., Haase,D., Lemcke,K., Mewes,H.W.,
            Stocker,S., Zaccaria,P., Bevan,M., Wilson,R.K., de la Bastide,M.,
            Habermann,K., Parnell,L., Dedhia,N., Gnoj,L., Schutz,K., Huang,E.,
            Spiegel,L., Sehkon,M., Murray,J., Sheet,P., Cordes,M.,
            Abu-Threideh,J., Stoneking,T., Kalicki,J., Graves,T., Harmon,G.,
            Edwards,J., Latreille,P., Courtney,L., Cloud,J., Abbott,A.,
            Scott,K., Johnson,D., Minx,P., Bentley,D., Fulton,B., Miller,N.,
            Greco,T., Kemp,K., Kramer,J., Fulton,L., Mardis,E., Dante,M.,
            Pepin,K., Hillier,L., Nelson,J., Spieth,J., Ryan,E., Andrews,S.,
            Geisel,C., Layman,D., Du,H., Ali,J., Berghoff,A., Jones,K.,
            Drone,K., Cotton,M., Joshu,C., Antonoiu,B., Zidanic,M., Strong,C.,
            Sun,H., Lamar,B., Yordan,C., Ma,P., Zhong,J., Preston,R., Vil,D.,
            Shekher,M., Matero,A., Shah,R., Swaby,I.K., O'Shaughnessy,A.,
            Rodriguez,M., Hoffmann,J., Till,S., Granat,S., Shohdy,N.,
            Hasegawa,A., Hameed,A., Lodhi,M., Johnson,A., Chen,E., Marra,M.,
            Martienssen,R. and McCombie,W.R.
  TITLE     Sequence and analysis of chromosome 4 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 402 (6763), 769-777 (1999)
   PUBMED   10617198
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=cv. Columbia
REFERENCE   2  (residues 1 to 600)
  AUTHORS   Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
            Schobel,S. and Town,C.D.
  TITLE     Araport11: a complete reannotation of the Arabidopsis thaliana
            reference genome
  JOURNAL   Plant J 89 (4), 789-804 (2017)
   PUBMED   27862469
  REMARK    GENOME REANNOTATION.;
            STRAIN=cv. Columbia
REFERENCE   3  (residues 1 to 600)
  AUTHORS   Gingerich,D.J., Gagne,J.M., Salter,D.W., Hellmann,H., Estelle,M.,
            Ma,L. and Vierstra,R.D.
  TITLE     Cullins 3a and 3b assemble with members of the broad
            complex/tramtrack/bric-a-brac (BTB) protein family to form
            essential ubiquitin-protein ligases (E3s) in Arabidopsis
  JOURNAL   J Biol Chem 280 (19), 18810-18821 (2005)
   PUBMED   15749712
  REMARK    DOMAIN BTB.
REFERENCE   4  (residues 1 to 600)
  AUTHORS   Liu,G., Holub,E.B., Alonso,J.M., Ecker,J.R. and Fobert,P.R.
  TITLE     An Arabidopsis NPR1-like gene, NPR4, is required for disease
            resistance
  JOURNAL   Plant J 41 (2), 304-318 (2005)
   PUBMED   15634206
  REMARK    GENE FAMILY, AND NOMENCLATURE.
REFERENCE   5  (residues 1 to 600)
  AUTHORS   Fu,Z.Q., Yan,S., Saleh,A., Wang,W., Ruble,J., Oka,N., Mohan,R.,
            Spoel,S.H., Tada,Y., Zheng,N. and Dong,X.
  TITLE     NPR3 and NPR4 are receptors for the immune signal salicylic acid in
            plants
  JOURNAL   Nature 486 (7402), 228-232 (2012)
   PUBMED   22699612
  REMARK    INTERACTION WITH NPR1.;
            STRAIN=cv. Columbia
            Publication Status: Online-Only
COMMENT     On Sep 14, 2005 this sequence version replaced gi:7487977.
            [FUNCTION] Salicylic acid (SA)-binding substrate-specific adapter
            of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which
            mediates the ubiquitination and subsequent proteasomal degradation
            of target proteins (By similarity). Transcription cofactor that
            represses gene expression in the absence of salicylic acid (SA),
            when attached to negative cis-elements (W-box) with WRKY
            transcription factors, but stimulates gene expression upon
            activation by SA, when sumoylated and attached to positive
            cis-elements (as-1) with TGA transcription factors, thus confering
            immunity through a series of gene regulations ending in a
            significant increase in antimicrobial and defense genes expression
            (By similarity). May be involved in regulating basal defense
            responses against pathogens, and may be involved in crosstalk
            between SA- and JA-dependent signaling pathways (By similarity).
            {ECO:0000250|UniProtKB:O22286, ECO:0000250|UniProtKB:P93002,
            ECO:0000250|UniProtKB:Q5ICL9}.
            [PATHWAY] Protein modification; protein ubiquitination.
            {ECO:0000250|UniProtKB:O22286}.
            [SUBUNIT] Interacts with NPR1 independently of SA.
            {ECO:0000269|PubMed:22699612}.
            [INTERACTION] Q9SZI3; P93002: NPR1; NbExp=2; IntAct=EBI-15987489,
            EBI-1392127.
            [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000250|UniProtKB:P93002}.
            Nucleus {ECO:0000250|UniProtKB:P93002}. Nucleus, nuclear body
            {ECO:0000250|UniProtKB:P93002}. Note=Accumulation in nucleus after
            induction by salicylic acid (SA) treatment or after pathogen
            infection. {ECO:0000250|UniProtKB:P93002}.
            [DOMAIN] The BTB/POZ domain mediates the interaction with some
            component of ubiquitin ligase complexes.
            {ECO:0000269|PubMed:15749712}.
            [SIMILARITY] Belongs to the plant 'ANKYRIN-BTB/POZ' family.
            'NPR1-like' subfamily. {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Arabidopsis thaliana"
                     /db_xref="taxon:3702"
     gene            1..600
                     /gene="NPR2"
                     /locus_tag="At4g26120"
                     /gene_synonym="F20B18.230"
     Protein         1..600
                     /product="Regulatory protein NPR2"
                     /note="BTB/POZ domain-containing protein NPR2"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..600
                     /region_name="Mature chain"
                     /note="Regulatory protein NPR2. /id=PRO_0000407991."
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P93002."
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P93002."
     Region          49..193
                     /region_name="BTB_POZ_NPR_plant"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ
                     (poxvirus and zinc finger) domain found in plant
                     regulatory proteins, NPR1-4, and similar proteins;
                     cd18310"
                     /db_xref="CDD:349619"
     Region          67..143
                     /region_name="Domain"
                     /note="BTB.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00037."
     Region          146..160
                     /region_name="Zinc finger region"
                     /note="C2HC NPR-type.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01391."
     Site            155
                     /site_type="modified"
                     /note="S-nitrosocysteine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01391."
     Region          230..270
                     /region_name="DUF3420"
                     /note="Domain of unknown function (DUF3420); pfam11900"
                     /db_xref="CDD:314729"
     Region          264..294
                     /region_name="Repetitive region"
                     /note="ANK 1. /evidence=ECO:0000255."
     Region          <269..>386
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          287..325
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          296..323
                     /region_name="Repetitive region"
                     /note="ANK 2. /evidence=ECO:0000255."
     Region          327..358
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          327..356
                     /region_name="Repetitive region"
                     /note="ANK 3. /evidence=ECO:0000255."
     Region          369..572
                     /region_name="NPR1_like_C"
                     /note="NPR1/NIM1 like defence protein C terminal;
                     pfam12313"
                     /db_xref="CDD:372037"
     Region          386..523
                     /region_name="Region of interest in the sequence"
                     /note="Salicylic acid-binding core (SBC).
                     /evidence=ECO:0000250|UniProtKB:Q5ICL9."
     Region          554..600
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          585..600
                     /region_name="Compositionally biased region"
                     /note="Basic and acidic residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN      
        1 mattttttta rfsdsyefsn tsgnsffaae ssldyptefl tppevsalkl lsnclesvfd
       61 spetfysdak lvlaggrevs fhrcilsari pvfksalatv keqkssttvk lqlkeiardy
      121 evgfdsvvav layvysgrvr sppkgasacv dddcchvacr skvdfmvevl ylsfvfqiqe
      181 lvtlyerqfl eivdkvvved ilvifkldtl cgttykklld rcieiivksd ielvsleksl
      241 pqhifkqiid irealclepp klerhvkniy kaldsddvel vkmllleght nldeayalhf
      301 aiahcavkta ydllelelad vnlrnprgyt vlhvaamrke pkliisllmk ganildttld
      361 grtalvivkr ltkaddykts tedgtpslkg glcievlehe qkleylspie aslslpvtpe
      421 elrmrllyye nrvalarllf pvetetvqgi akleetceft asslepdhhi gekrtsldln
      481 mapfqihekh lsrlralckt velgkryfkr csldhfmdte dlnhlasvee dtpekrlqkk
      541 qrymelqetl mktfsedkee cgksstpkpt savrsnrkls hrrlkvdkrd flkrpygngd
//
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