LOCUS ATL74_ARATH 159 aa linear PLN 02-OCT-2024
DEFINITION RecName: Full=RING-H2 finger protein ATL74; AltName: Full=RING-type
E3 ubiquitin transferase ATL74.
ACCESSION Q9LZV8
VERSION Q9LZV8.1
DBSOURCE UniProtKB: locus ATL74_ARATH, accession Q9LZV8;
class: standard.
created: Jul 5, 2005.
sequence updated: Oct 1, 2000.
annotation updated: Oct 2, 2024.
xrefs: AL162351.1, CAB82758.1, CP002688.1, AED90404.1, BT010682.1,
AAR20739.1, BT010973.1, AAR24751.1, T48209, NP_195808.1
xrefs (non-sequence databases): AlphaFoldDB:Q9LZV8, SMR:Q9LZV8,
PaxDb:3702-AT5G01880.1, ProteomicsDB:246577,
EnsemblPlants:AT5G01880.1, EnsemblPlants:AT5G01880.1,
EnsemblPlants:AT5G01880, GeneID:831691, Gramene:AT5G01880.1,
KEGG:ath:AT5G01880, Araport:AT5G01880, TAIR:AT5G01880,
eggNOG:KOG0800, HOGENOM:CLU_013137_9_3_1, InParanoid:Q9LZV8,
OMA:RILPECC, OrthoDB:5474929at2759, PhylomeDB:Q9LZV8,
UniPathway:UPA00143, PRO:PR:Q9LZV8, Proteomes:UP000006548,
ExpressionAtlas:Q9LZV8, GO:0016020, GO:0046872, GO:0016740,
GO:0016567, CDD:cd16461, Gene3D:3.30.40.10, InterPro:IPR044602,
InterPro:IPR001841, InterPro:IPR013083, PANTHER:PTHR46905:SF22,
PANTHER:PTHR46905, Pfam:PF13639, SMART:SM00184, SUPFAM:SSF57850,
PROSITE:PS50089
KEYWORDS Membrane; Metal-binding; Reference proteome; Transferase;
Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc;
Zinc-finger.
SOURCE Arabidopsis thaliana (thale cress)
ORGANISM Arabidopsis thaliana
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
Camelineae; Arabidopsis.
REFERENCE 1 (residues 1 to 159)
AUTHORS Tabata,S., Kaneko,T., Nakamura,Y., Kotani,H., Kato,T., Asamizu,E.,
Miyajima,N., Sasamoto,S., Kimura,T., Hosouchi,T., Kawashima,K.,
Kohara,M., Matsumoto,M., Matsuno,A., Muraki,A., Nakayama,S.,
Nakazaki,N., Naruo,K., Okumura,S., Shinpo,S., Takeuchi,C., Wada,T.,
Watanabe,A., Yamada,M., Yasuda,M., Sato,S., de la Bastide,M.,
Huang,E., Spiegel,L., Gnoj,L., O'Shaughnessy,A., Preston,R.,
Habermann,K., Murray,J., Johnson,D., Rohlfing,T., Nelson,J.,
Stoneking,T., Pepin,K., Spieth,J., Sekhon,M., Armstrong,J.,
Becker,M., Belter,E., Cordum,H., Cordes,M., Courtney,L.,
Courtney,W., Dante,M., Du,H., Edwards,J., Fryman,J., Haakensen,B.,
Lamar,E., Latreille,P., Leonard,S., Meyer,R., Mulvaney,E.,
Ozersky,P., Riley,A., Strowmatt,C., Wagner-McPherson,C., Wollam,A.,
Yoakum,M., Bell,M., Dedhia,N., Parnell,L., Shah,R., Rodriguez,M.,
See,L.H., Vil,D., Baker,J., Kirchoff,K., Toth,K., King,L.,
Bahret,A., Miller,B., Marra,M., Martienssen,R., McCombie,W.R.,
Wilson,R.K., Murphy,G., Bancroft,I., Volckaert,G., Wambutt,R.,
Dusterhoft,A., Stiekema,W., Pohl,T., Entian,K.D., Terryn,N.,
Hartley,N., Bent,E., Johnson,S., Langham,S.A., McCullagh,B.,
Robben,J., Grymonprez,B., Zimmermann,W., Ramsperger,U., Wedler,H.,
Balke,K., Wedler,E., Peters,S., van Staveren,M., Dirkse,W.,
Mooijman,P., Lankhorst,R.K., Weitzenegger,T., Bothe,G., Rose,M.,
Hauf,J., Berneiser,S., Hempel,S., Feldpausch,M., Lamberth,S.,
Villarroel,R., Gielen,J., Ardiles,W., Bents,O., Lemcke,K.,
Kolesov,G., Mayer,K., Rudd,S., Schoof,H., Schueller,C.,
Zaccaria,P., Mewes,H.W., Bevan,M. and Fransz,P.
CONSRTM Kazusa DNA Research Institute; Cold Spring Harbor and Washington
University in St Louis Sequencing Consortium; European Union
Arabidopsis Genome Sequencing Consortium
TITLE Sequence and analysis of chromosome 5 of the plant Arabidopsis
thaliana
JOURNAL Nature 408 (6814), 823-826 (2000)
PUBMED 11130714
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=cv. Columbia
REFERENCE 2 (residues 1 to 159)
AUTHORS Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
Schobel,S. and Town,C.D.
TITLE Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome
JOURNAL Plant J 89 (4), 789-804 (2017)
PUBMED 27862469
REMARK GENOME REANNOTATION.;
STRAIN=cv. Columbia
REFERENCE 3 (residues 1 to 159)
AUTHORS Shinn,P., Chen,H., Cheuk,R.F., Kim,C.J. and Ecker,J.R.
TITLE Direct Submission
JOURNAL Submitted (??-DEC-2003) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
STRAIN=cv. Columbia
REFERENCE 4 (residues 1 to 159)
AUTHORS Kosarev,P., Mayer,K.F. and Hardtke,C.S.
TITLE Evaluation and classification of RING-finger domains encoded by the
Arabidopsis genome
JOURNAL Genome Biol 3 (4), RESEARCH0016 (2002)
PUBMED 11983057
REMARK GENE FAMILY ORGANIZATION.
REFERENCE 5 (residues 1 to 159)
AUTHORS Serrano,M., Parra,S., Alcaraz,L.D. and Guzman,P.
TITLE The ATL gene family from Arabidopsis thaliana and Oryza sativa
comprises a large number of putative ubiquitin ligases of the
RING-H2 type
JOURNAL J Mol Evol 62 (4), 434-445 (2006)
PUBMED 16557337
REMARK NOMENCLATURE, AND GENE FAMILY ORGANIZATION.
COMMENT On Jul 5, 2005 this sequence version replaced gi:11358136.
[CATALYTIC ACTIVITY] Reaction=S-ubiquitinyl-[E2
ubiquitin-conjugating enzyme]-L-cysteine + [acceptor
protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine +
N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;
Evidence={ECO:0000305}.
[PATHWAY] Protein modification; protein ubiquitination.
[SUBCELLULAR LOCATION] Membrane {ECO:0000305}; Single-pass membrane
protein {ECO:0000305}.
[DOMAIN] The RING-type zinc finger domain mediates binding to an E2
ubiquitin-conjugating enzyme. {ECO:0000250}.
[SIMILARITY] Belongs to the RING-type zinc finger family. ATL
subfamily. {ECO:0000305}.
FEATURES Location/Qualifiers
source 1..159
/organism="Arabidopsis thaliana"
/db_xref="taxon:3702"
gene 1..159
/gene="ATL74"
/locus_tag="At5g01880"
/gene_synonym="T20L15_150"
Protein 1..159
/product="RING-H2 finger protein ATL74"
/EC_number="2.3.2.27"
/note="RING-type E3 ubiquitin transferase ATL74"
/UniProtKB_evidence="Evidence at transcript level"
Region 1..159
/region_name="Mature chain"
/note="RING-H2 finger protein ATL74. /id=PRO_0000055807."
Region 35..55
/region_name="Transmembrane region"
/note="Helical. /evidence=ECO:0000255."
Region 104..147
/region_name="RING-H2_EL5-like"
/note="RING finger, H2 subclass, found in rice E3
ubiquitin-protein ligase EL5 and similar proteins;
cd16461"
/db_xref="CDD:438124"
Region 105..147
/region_name="Zinc finger region"
/note="RING-type; atypical.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00175."
Site 132..137
/site_type="active"
/note="putative active site [active]"
/db_xref="CDD:438124"
ORIGIN
1 mhrllleshg ggnetsgsgg gdgytrdmnf danmviilaa llcalilalg lnsilrcamr
61 cgfglsssaa agtvadragl kkrelkkfpv aeygsgevki aatecaiclg efadgervrv
121 lppcnhsfhm scidtwlvsh sscpncrhsl ievhvagse
//