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RecName: Full=Shaggy-related protein kinase epsilon; AltName: Full=ASK-epsilon; AltName: Full=Shaggy-related protein kinase 13; Short=AtSK13

UniProtKB/Swiss-Prot: Q8VZD5.1

Identical Proteins FASTA Graphics 

LOCUS       KSG5_ARATH               410 aa            linear   PLN 27-NOV-2024
DEFINITION  RecName: Full=Shaggy-related protein kinase epsilon; AltName:
            Full=ASK-epsilon; AltName: Full=Shaggy-related protein kinase 13;
            Short=AtSK13.
ACCESSION   Q8VZD5
VERSION     Q8VZD5.1
DBSOURCE    UniProtKB: locus KSG5_ARATH, accession Q8VZD5;
            class: standard.
            extra accessions:Q9LYJ6
            created: Apr 26, 2004.
            sequence updated: Mar 1, 2002.
            annotation updated: Nov 27, 2024.
            xrefs: AL163792.1, CAB87631.1, CP002688.1, AED92057.1, ANM68202.1,
            AY065043.1, AAL57679.1, BT010466.1, AAQ65089.1, T48637,
            NP_001329975.1, NP_196968.2
            xrefs (non-sequence databases): AlphaFoldDB:Q8VZD5, SMR:Q8VZD5,
            BioGRID:16593, IntAct:Q8VZD5, STRING:3702.Q8VZD5, iPTMnet:Q8VZD5,
            PaxDb:3702-AT5G14640.1, ProteomicsDB:237111,
            EnsemblPlants:AT5G14640.1, EnsemblPlants:AT5G14640.1,
            EnsemblPlants:AT5G14640, EnsemblPlants:AT5G14640.2,
            EnsemblPlants:AT5G14640.2, GeneID:831316, Gramene:AT5G14640.1,
            Gramene:AT5G14640.2, KEGG:ath:AT5G14640, Araport:AT5G14640,
            TAIR:AT5G14640, eggNOG:KOG0658, HOGENOM:CLU_000288_181_20_1,
            InParanoid:Q8VZD5, OMA:TKMATGR, OrthoDB:2872909at2759,
            PhylomeDB:Q8VZD5, PRO:PR:Q8VZD5, Proteomes:UP000006548,
            ExpressionAtlas:Q8VZD5, GO:0005524, GO:0044024, GO:0106310,
            GO:0004674, GO:0006972, GO:0046777, GO:0009651, CDD:cd14137,
            FunFam:3.30.200.20:FF:000009, FunFam:1.10.510.10:FF:000082,
            Gene3D:1.10.510.10, InterPro:IPR050591, InterPro:IPR011009,
            InterPro:IPR000719, InterPro:IPR017441, InterPro:IPR008271,
            InterPro:IPR039192, PANTHER:PTHR24057, PANTHER:PTHR24057:SF0,
            Pfam:PF00069, SMART:SM00220, SUPFAM:SSF56112, PROSITE:PS00107,
            PROSITE:PS50011, PROSITE:PS00108
KEYWORDS    Acetylation; ATP-binding; Kinase; Nucleotide-binding;
            Phosphoprotein; Reference proteome; Serine/threonine-protein
            kinase; Transferase.
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (residues 1 to 410)
  AUTHORS   Tabata,S., Kaneko,T., Nakamura,Y., Kotani,H., Kato,T., Asamizu,E.,
            Miyajima,N., Sasamoto,S., Kimura,T., Hosouchi,T., Kawashima,K.,
            Kohara,M., Matsumoto,M., Matsuno,A., Muraki,A., Nakayama,S.,
            Nakazaki,N., Naruo,K., Okumura,S., Shinpo,S., Takeuchi,C., Wada,T.,
            Watanabe,A., Yamada,M., Yasuda,M., Sato,S., de la Bastide,M.,
            Huang,E., Spiegel,L., Gnoj,L., O'Shaughnessy,A., Preston,R.,
            Habermann,K., Murray,J., Johnson,D., Rohlfing,T., Nelson,J.,
            Stoneking,T., Pepin,K., Spieth,J., Sekhon,M., Armstrong,J.,
            Becker,M., Belter,E., Cordum,H., Cordes,M., Courtney,L.,
            Courtney,W., Dante,M., Du,H., Edwards,J., Fryman,J., Haakensen,B.,
            Lamar,E., Latreille,P., Leonard,S., Meyer,R., Mulvaney,E.,
            Ozersky,P., Riley,A., Strowmatt,C., Wagner-McPherson,C., Wollam,A.,
            Yoakum,M., Bell,M., Dedhia,N., Parnell,L., Shah,R., Rodriguez,M.,
            See,L.H., Vil,D., Baker,J., Kirchoff,K., Toth,K., King,L.,
            Bahret,A., Miller,B., Marra,M., Martienssen,R., McCombie,W.R.,
            Wilson,R.K., Murphy,G., Bancroft,I., Volckaert,G., Wambutt,R.,
            Dusterhoft,A., Stiekema,W., Pohl,T., Entian,K.D., Terryn,N.,
            Hartley,N., Bent,E., Johnson,S., Langham,S.A., McCullagh,B.,
            Robben,J., Grymonprez,B., Zimmermann,W., Ramsperger,U., Wedler,H.,
            Balke,K., Wedler,E., Peters,S., van Staveren,M., Dirkse,W.,
            Mooijman,P., Lankhorst,R.K., Weitzenegger,T., Bothe,G., Rose,M.,
            Hauf,J., Berneiser,S., Hempel,S., Feldpausch,M., Lamberth,S.,
            Villarroel,R., Gielen,J., Ardiles,W., Bents,O., Lemcke,K.,
            Kolesov,G., Mayer,K., Rudd,S., Schoof,H., Schueller,C.,
            Zaccaria,P., Mewes,H.W., Bevan,M. and Fransz,P.
  CONSRTM   Kazusa DNA Research Institute; Cold Spring Harbor and Washington
            University in St Louis Sequencing Consortium; European Union
            Arabidopsis Genome Sequencing Consortium
  TITLE     Sequence and analysis of chromosome 5 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 408 (6814), 823-826 (2000)
   PUBMED   11130714
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=cv. Columbia
REFERENCE   2  (residues 1 to 410)
  AUTHORS   Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
            Schobel,S. and Town,C.D.
  TITLE     Araport11: a complete reannotation of the Arabidopsis thaliana
            reference genome
  JOURNAL   Plant J 89 (4), 789-804 (2017)
   PUBMED   27862469
  REMARK    GENOME REANNOTATION.;
            STRAIN=cv. Columbia
REFERENCE   3  (residues 1 to 410)
  AUTHORS   Yamada,K., Lim,J., Dale,J.M., Chen,H., Shinn,P., Palm,C.J.,
            Southwick,A.M., Wu,H.C., Kim,C., Nguyen,M., Pham,P., Cheuk,R.,
            Karlin-Newmann,G., Liu,S.X., Lam,B., Sakano,H., Wu,T., Yu,G.,
            Miranda,M., Quach,H.L., Tripp,M., Chang,C.H., Lee,J.M., Toriumi,M.,
            Chan,M.M., Tang,C.C., Onodera,C.S., Deng,J.M., Akiyama,K.,
            Ansari,Y., Arakawa,T., Banh,J., Banno,F., Bowser,L., Brooks,S.,
            Carninci,P., Chao,Q., Choy,N., Enju,A., Goldsmith,A.D., Gurjal,M.,
            Hansen,N.F., Hayashizaki,Y., Johnson-Hopson,C., Hsuan,V.W.,
            Iida,K., Karnes,M., Khan,S., Koesema,E., Ishida,J., Jiang,P.X.,
            Jones,T., Kawai,J., Kamiya,A., Meyers,C., Nakajima,M., Narusaka,M.,
            Seki,M., Sakurai,T., Satou,M., Tamse,R., Vaysberg,M.,
            Wallender,E.K., Wong,C., Yamamura,Y., Yuan,S., Shinozaki,K.,
            Davis,R.W., Theologis,A. and Ecker,J.R.
  TITLE     Empirical analysis of transcriptional activity in the Arabidopsis
            genome
  JOURNAL   Science 302 (5646), 842-846 (2003)
   PUBMED   14593172
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            STRAIN=cv. Columbia
REFERENCE   4  (residues 1 to 410)
  AUTHORS   Zhu,J.Y., Li,Y., Cao,D.M., Yang,H., Oh,E., Bi,Y., Zhu,S. and
            Wang,Z.Y.
  TITLE     The F-box Protein KIB1 Mediates Brassinosteroid-Induced
            Inactivation and Degradation of GSK3-like Kinases in Arabidopsis
  JOURNAL   Mol Cell 66 (5), 648-657 (2017)
   PUBMED   28575660
  REMARK    INTERACTION WITH KIB1.;
            STRAIN=cv. Columbia, and cv. Wassilewskija
COMMENT     On Jul 5, 2005 this sequence version replaced gi:11259751.
            [FUNCTION] May mediate extracellular signals to regulate
            transcription in differentiating cells. {ECO:0000250}.
            [CATALYTIC ACTIVITY] Reaction=L-seryl-[protein] + ATP =
            O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989,
            Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378,
            ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
            ChEBI:CHEBI:456216; EC=2.7.11.1.
            [CATALYTIC ACTIVITY] Reaction=L-threonyl-[protein] + ATP =
            O-phospho-L-threonyl-[protein] + ADP + H(+); Xref=Rhea:RHEA:46608,
            Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378,
            ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977,
            ChEBI:CHEBI:456216; EC=2.7.11.1.
            [SUBUNIT] Binds to KIB1. {ECO:0000269|PubMed:28575660}.
            [PTM] Autophosphorylated mainly on threonine and serine residues.
            {ECO:0000250}.
            [SIMILARITY] Belongs to the protein kinase superfamily. CMGC
            Ser/Thr protein kinase family. GSK-3 subfamily. {ECO:0000305}.
            [SEQUENCE CAUTION] Sequence=CAB87631.1; Type=Erroneous gene model
            prediction; Evidence={ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Arabidopsis thaliana"
                     /db_xref="taxon:3702"
     gene            1..410
                     /gene="ASK5"
                     /locus_tag="At5g14640"
                     /gene_synonym="SK13"
                     /gene_synonym="T15N1.130"
     Protein         1..410
                     /product="Shaggy-related protein kinase epsilon"
                     /EC_number="2.7.11.1"
                     /note="ASK-epsilon; Shaggy-related protein kinase 13;
                     AtSK13"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          2..410
                     /region_name="Mature chain"
                     /note="Shaggy-related protein kinase epsilon.
                     /id=PRO_0000086220."
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P43288."
     Region          69..361
                     /region_name="STKc_GSK3"
                     /note="The catalytic domain of the Serine/Threonine
                     Kinase, Glycogen Synthase Kinase 3; cd14137"
                     /db_xref="CDD:271039"
     Region          74..358
                     /region_name="Domain"
                     /note="Protein kinase.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00159."
     Site            order(80..84,88,101,103,114,128,149..152,155,157..158,199,
                     201,203..204,206,218,221,232,234..237,239,277)
                     /site_type="active"
                     /db_xref="CDD:271039"
     Site            order(80..83,88,101,103,128,149..152,155,201,203..204,206,
                     218)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271039"
     Site            order(84..85,230..238,246..247,278..282,284..285,289,
                     309..312)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:271039"
     Site            order(114,157,199,201,221,232,234..237,239,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271039"
     Site            199
                     /site_type="active"
                     /note="Proton acceptor.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00159,
                     ECO:0000255|PROSITE-ProRule:PRU10027."
     Site            order(217..227,229..239)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271039"
     Site            234
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q39011."
     Site            order(246,281..282,284..285,288..289,309..314)
                     /site_type="other"
                     /note="axin binding site [polypeptide binding]"
                     /db_xref="CDD:271039"
ORIGIN      
        1 masvgtlpas smatkqsnas icaeklpegi nemkikddke meaavvdgng tetghiivtt
       61 iggkngqpkq tisymaeriv gqgsfgivfq akcletgetv aikkvlqdkr yknrelqtmr
      121 lldhpnvvsl khcffsttek delylnlvle yvpetvyrvs khysranqrm piiyvklyty
      181 qicralayih ggvgvchrdi kpqnllvnph thqvklcdfg sakvlvkgep nisyicsryy
      241 rapelifgat eytttidiws agcvlaelll gqplfpgesg vdqlveiikv lgtptreeik
      301 cmnpnytefk fpqikahpwh kifhkrtppe avdlvsrllq yspnlrstam eaivhpffde
      361 lrdpntrlpn gralpplfnf kpqelkgasl ellsklipdh arkqcsflal
//
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Reference sequence information

More about the SK13 gene

  • SK13 gene
    Also Known As: AT5G14640, ATSK13, SHAG...

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