RecName: Full=R-spondin-4; AltName: Full=Cysteine-rich and single thro - Protein

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The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. [Nat Genet. 2006]
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.
Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh MT, Rüschendorf F, Sinclair C, Hopsu-Havu VK, Tidman N, Moss C, et al. Nat Genet. 2006 Nov; 38(11):1245-7. Epub 2006 Oct 15.
Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway. [FASEB J. 2020]
Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
Liu S, Gao Y, Zhang L, Yin Y, Zhang W. FASEB J. 2020 Nov; 34(11):14946-14959. Epub 2020 Sep 14.
A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development. [Genesis. 2012]
A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development.
Neufeld S, Rosin JM, Ambasta A, Hui K, Shaneman V, Crowder R, Vickerman L, Cobb J. Genesis. 2012 Oct; 50(10):741-9. Epub 2012 Jun 19.

RefSeq protein isoforms
See 2 reference sequence protein isoforms for the Rspo4 gene.

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Mouse Genome Informatics (MGI) [Mouse Genome Informatics (MGI)]
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Protein