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RecName: Full=Serine hydroxymethyltransferase 7; Short=AtSHMT7; AltName: Full=Glycine hydroxymethyltransferase 7; AltName: Full=Serine methylase 7

UniProtKB/Swiss-Prot: Q84WV0.1

Identical Proteins FASTA Graphics 

LOCUS       GLYC7_ARATH               14 aa            linear   PLN 27-NOV-2024
DEFINITION  RecName: Full=Serine hydroxymethyltransferase 7; Short=AtSHMT7;
            AltName: Full=Glycine hydroxymethyltransferase 7; AltName:
            Full=Serine methylase 7.
ACCESSION   Q84WV0 REGION: 424..437
VERSION     Q84WV0.1
DBSOURCE    UniProtKB: locus GLYC7_ARATH, accession Q84WV0;
            class: standard.
            extra accessions:Q8LFB5,Q9C8X6
            created: May 29, 2013.
            sequence updated: Jun 1, 2003.
            annotation updated: Nov 27, 2024.
            xrefs: AC021199.7, AAG52195.1, CP002684.1, AEE31862.1, BT002738.1,
            AAO22567.1, AY084945.1, AAM61506.1, F86484, NP_564473.1, 7QX8_A,
            7QX8_B, 7QX8_C, 7QX8_D, 7QX8_E, 7QX8_F, 7QX8_G, 7QX8_H, 7QX8_I,
            7QX8_J, 7QX8_K, 7QX8_L
            xrefs (non-sequence databases): PDBsum:7QX8, AlphaFoldDB:Q84WV0,
            SMR:Q84WV0, STRING:3702.Q84WV0, iPTMnet:Q84WV0,
            PaxDb:3702-AT1G36370.1, ProteomicsDB:248529,
            EnsemblPlants:AT1G36370.1, EnsemblPlants:AT1G36370.1,
            EnsemblPlants:AT1G36370, GeneID:840543, Gramene:AT1G36370.1,
            KEGG:ath:AT1G36370, Araport:AT1G36370, TAIR:AT1G36370,
            eggNOG:KOG2467, HOGENOM:CLU_022477_0_1_1, InParanoid:Q84WV0,
            OMA:WGDQPLH, OrthoDB:5358603at2759, PhylomeDB:Q84WV0,
            BioCyc:ARA:AT1G36370-MONOMER, UniPathway:UPA00193, PRO:PR:Q84WV0,
            Proteomes:UP000006548, ExpressionAtlas:Q84WV0, GO:0005737,
            GO:0005634, GO:0004372, GO:0030170, GO:0019264, GO:0046686,
            GO:0046500, GO:0055063, GO:0035999, CDD:cd00378,
            FunFam:3.40.640.10:FF:000097, Gene3D:3.90.1150.10,
            Gene3D:3.40.640.10, HAMAP:MF_00051, InterPro:IPR015424,
            InterPro:IPR015421, InterPro:IPR015422, InterPro:IPR001085,
            InterPro:IPR049943, InterPro:IPR019798, InterPro:IPR039429,
            PANTHER:PTHR11680, PANTHER:PTHR11680:SF7, Pfam:PF00464,
            SUPFAM:SSF53383, PROSITE:PS00096
KEYWORDS    3D-structure; Cytoplasm; One-carbon metabolism; Pyridoxal
            phosphate; Reference proteome; Transferase.
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (residues )
  AUTHORS   Theologis,A., Ecker,J.R., Palm,C.J., Federspiel,N.A., Kaul,S.,
            White,O., Alonso,J., Altafi,H., Araujo,R., Bowman,C.L.,
            Brooks,S.Y., Buehler,E., Chan,A., Chao,Q., Chen,H., Cheuk,R.F.,
            Chin,C.W., Chung,M.K., Conn,L., Conway,A.B., Conway,A.R.,
            Creasy,T.H., Dewar,K., Dunn,P., Etgu,P., Feldblyum,T.V., Feng,J.,
            Fong,B., Fujii,C.Y., Gill,J.E., Goldsmith,A.D., Haas,B.,
            Hansen,N.F., Hughes,B., Huizar,L., Hunter,J.L., Jenkins,J.,
            Johnson-Hopson,C., Khan,S., Khaykin,E., Kim,C.J., Koo,H.L.,
            Kremenetskaia,I., Kurtz,D.B., Kwan,A., Lam,B., Langin-Hooper,S.,
            Lee,A., Lee,J.M., Lenz,C.A., Li,J.H., Li,Y., Lin,X., Liu,S.X.,
            Liu,Z.A., Luros,J.S., Maiti,R., Marziali,A., Militscher,J.,
            Miranda,M., Nguyen,M., Nierman,W.C., Osborne,B.I., Pai,G.,
            Peterson,J., Pham,P.K., Rizzo,M., Rooney,T., Rowley,D., Sakano,H.,
            Salzberg,S.L., Schwartz,J.R., Shinn,P., Southwick,A.M., Sun,H.,
            Tallon,L.J., Tambunga,G., Toriumi,M.J., Town,C.D., Utterback,T.,
            Van Aken,S., Vaysberg,M., Vysotskaia,V.S., Walker,M., Wu,D., Yu,G.,
            Fraser,C.M., Venter,J.C. and Davis,R.W.
  TITLE     Sequence and analysis of chromosome 1 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 408 (6814), 816-820 (2000)
   PUBMED   11130712
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=cv. Columbia
REFERENCE   2  (residues )
  AUTHORS   Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
            Schobel,S. and Town,C.D.
  TITLE     Araport11: a complete reannotation of the Arabidopsis thaliana
            reference genome
  JOURNAL   Plant J 89 (4), 789-804 (2017)
   PUBMED   27862469
  REMARK    GENOME REANNOTATION.;
            STRAIN=cv. Columbia
REFERENCE   3  (residues )
  AUTHORS   Yamada,K., Lim,J., Dale,J.M., Chen,H., Shinn,P., Palm,C.J.,
            Southwick,A.M., Wu,H.C., Kim,C., Nguyen,M., Pham,P., Cheuk,R.,
            Karlin-Newmann,G., Liu,S.X., Lam,B., Sakano,H., Wu,T., Yu,G.,
            Miranda,M., Quach,H.L., Tripp,M., Chang,C.H., Lee,J.M., Toriumi,M.,
            Chan,M.M., Tang,C.C., Onodera,C.S., Deng,J.M., Akiyama,K.,
            Ansari,Y., Arakawa,T., Banh,J., Banno,F., Bowser,L., Brooks,S.,
            Carninci,P., Chao,Q., Choy,N., Enju,A., Goldsmith,A.D., Gurjal,M.,
            Hansen,N.F., Hayashizaki,Y., Johnson-Hopson,C., Hsuan,V.W.,
            Iida,K., Karnes,M., Khan,S., Koesema,E., Ishida,J., Jiang,P.X.,
            Jones,T., Kawai,J., Kamiya,A., Meyers,C., Nakajima,M., Narusaka,M.,
            Seki,M., Sakurai,T., Satou,M., Tamse,R., Vaysberg,M.,
            Wallender,E.K., Wong,C., Yamamura,Y., Yuan,S., Shinozaki,K.,
            Davis,R.W., Theologis,A. and Ecker,J.R.
  TITLE     Empirical analysis of transcriptional activity in the Arabidopsis
            genome
  JOURNAL   Science 302 (5646), 842-846 (2003)
   PUBMED   14593172
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            STRAIN=cv. Columbia
REFERENCE   4  (residues )
  AUTHORS   Brover,V.V., Troukhan,M.E., Alexandrov,N.A., Lu,Y.-P., Flavell,R.B.
            and Feldmann,K.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-MAR-2002) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
REFERENCE   5  (residues )
  AUTHORS   Bauwe,H. and Kolukisaoglu,U.
  TITLE     Genetic manipulation of glycine decarboxylation
  JOURNAL   J Exp Bot 54 (387), 1523-1535 (2003)
   PUBMED   12730263
  REMARK    REVIEW.
REFERENCE   6  (residues )
  AUTHORS   Zhang,Y., Sun,K., Sandoval,F.J., Santiago,K. and Roje,S.
  TITLE     One-carbon metabolism in plants: characterization of a plastid
            serine hydroxymethyltransferase
  JOURNAL   Biochem J 430 (1), 97-105 (2010)
   PUBMED   20518745
  REMARK    GENE FAMILY.
COMMENT     On or before Jun 5, 2013 this sequence version replaced
            gi:75246061, gi:75262210.
            [FUNCTION] Catalyzes the interconversion of serine and glycine.
            {ECO:0000250}.
            [CATALYTIC ACTIVITY]
            Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine +
            H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine;
            Xref=Rhea:RHEA:15481, ChEBI:CHEBI:15377, ChEBI:CHEBI:15636,
            ChEBI:CHEBI:33384, ChEBI:CHEBI:57305, ChEBI:CHEBI:57453;
            EC=2.1.2.1.
            [COFACTOR] Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
            Evidence={ECO:0000250}.
            [PATHWAY] One-carbon metabolism; tetrahydrofolate interconversion.
            [SUBUNIT] Homotetramer. {ECO:0000250}.
            [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000305}.
            [SIMILARITY] Belongs to the SHMT family. {ECO:0000305}.
            [SEQUENCE CAUTION] Sequence=AAG52195.1; Type=Erroneous initiation;
            Note=Truncated N-terminus.; Evidence={ECO:0000305};
            Sequence=AAM61506.1; Type=Erroneous initiation; Note=Truncated
            N-terminus.; Evidence={ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..14
                     /organism="Arabidopsis thaliana"
                     /db_xref="taxon:3702"
     gene            <1..>14
                     /gene="SHM7"
                     /locus_tag="At1g36370"
                     /gene_synonym="F7F23.9"
                     /gene_synonym="SHMT7"
     Protein         <1..>14
                     /product="Serine hydroxymethyltransferase 7"
                     /EC_number="2.1.2.1"
                     /note="AtSHMT7; Glycine hydroxymethyltransferase 7; Serine
                     methylase 7"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          <1..>14
                     /region_name="Mature chain"
                     /note="Serine hydroxymethyltransferase 7.
                     /id=PRO_0000422352."
     Region          <1..>14
                     /region_name="PLN02271"
                     /note="serine hydroxymethyltransferase"
                     /db_xref="CDD:215153"
     Region          1..14
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7QX8."
ORIGIN      
        1 nnhiaalaia lkqv
//
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for serine hydroxymethyltransferase 7 (NP_564473.1).

More about the SHM7 gene

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