LOCUS GLYC7_ARATH 14 aa linear PLN 27-NOV-2024
DEFINITION RecName: Full=Serine hydroxymethyltransferase 7; Short=AtSHMT7;
AltName: Full=Glycine hydroxymethyltransferase 7; AltName:
Full=Serine methylase 7.
ACCESSION Q84WV0 REGION: 424..437
VERSION Q84WV0.1
DBSOURCE UniProtKB: locus GLYC7_ARATH, accession Q84WV0;
class: standard.
extra accessions:Q8LFB5,Q9C8X6
created: May 29, 2013.
sequence updated: Jun 1, 2003.
annotation updated: Nov 27, 2024.
xrefs: AC021199.7, AAG52195.1, CP002684.1, AEE31862.1, BT002738.1,
AAO22567.1, AY084945.1, AAM61506.1, F86484, NP_564473.1, 7QX8_A,
7QX8_B, 7QX8_C, 7QX8_D, 7QX8_E, 7QX8_F, 7QX8_G, 7QX8_H, 7QX8_I,
7QX8_J, 7QX8_K, 7QX8_L
xrefs (non-sequence databases): PDBsum:7QX8, AlphaFoldDB:Q84WV0,
SMR:Q84WV0, STRING:3702.Q84WV0, iPTMnet:Q84WV0,
PaxDb:3702-AT1G36370.1, ProteomicsDB:248529,
EnsemblPlants:AT1G36370.1, EnsemblPlants:AT1G36370.1,
EnsemblPlants:AT1G36370, GeneID:840543, Gramene:AT1G36370.1,
KEGG:ath:AT1G36370, Araport:AT1G36370, TAIR:AT1G36370,
eggNOG:KOG2467, HOGENOM:CLU_022477_0_1_1, InParanoid:Q84WV0,
OMA:WGDQPLH, OrthoDB:5358603at2759, PhylomeDB:Q84WV0,
BioCyc:ARA:AT1G36370-MONOMER, UniPathway:UPA00193, PRO:PR:Q84WV0,
Proteomes:UP000006548, ExpressionAtlas:Q84WV0, GO:0005737,
GO:0005634, GO:0004372, GO:0030170, GO:0019264, GO:0046686,
GO:0046500, GO:0055063, GO:0035999, CDD:cd00378,
FunFam:3.40.640.10:FF:000097, Gene3D:3.90.1150.10,
Gene3D:3.40.640.10, HAMAP:MF_00051, InterPro:IPR015424,
InterPro:IPR015421, InterPro:IPR015422, InterPro:IPR001085,
InterPro:IPR049943, InterPro:IPR019798, InterPro:IPR039429,
PANTHER:PTHR11680, PANTHER:PTHR11680:SF7, Pfam:PF00464,
SUPFAM:SSF53383, PROSITE:PS00096
KEYWORDS 3D-structure; Cytoplasm; One-carbon metabolism; Pyridoxal
phosphate; Reference proteome; Transferase.
SOURCE Arabidopsis thaliana (thale cress)
ORGANISM Arabidopsis thaliana
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
Camelineae; Arabidopsis.
REFERENCE 1 (residues )
AUTHORS Theologis,A., Ecker,J.R., Palm,C.J., Federspiel,N.A., Kaul,S.,
White,O., Alonso,J., Altafi,H., Araujo,R., Bowman,C.L.,
Brooks,S.Y., Buehler,E., Chan,A., Chao,Q., Chen,H., Cheuk,R.F.,
Chin,C.W., Chung,M.K., Conn,L., Conway,A.B., Conway,A.R.,
Creasy,T.H., Dewar,K., Dunn,P., Etgu,P., Feldblyum,T.V., Feng,J.,
Fong,B., Fujii,C.Y., Gill,J.E., Goldsmith,A.D., Haas,B.,
Hansen,N.F., Hughes,B., Huizar,L., Hunter,J.L., Jenkins,J.,
Johnson-Hopson,C., Khan,S., Khaykin,E., Kim,C.J., Koo,H.L.,
Kremenetskaia,I., Kurtz,D.B., Kwan,A., Lam,B., Langin-Hooper,S.,
Lee,A., Lee,J.M., Lenz,C.A., Li,J.H., Li,Y., Lin,X., Liu,S.X.,
Liu,Z.A., Luros,J.S., Maiti,R., Marziali,A., Militscher,J.,
Miranda,M., Nguyen,M., Nierman,W.C., Osborne,B.I., Pai,G.,
Peterson,J., Pham,P.K., Rizzo,M., Rooney,T., Rowley,D., Sakano,H.,
Salzberg,S.L., Schwartz,J.R., Shinn,P., Southwick,A.M., Sun,H.,
Tallon,L.J., Tambunga,G., Toriumi,M.J., Town,C.D., Utterback,T.,
Van Aken,S., Vaysberg,M., Vysotskaia,V.S., Walker,M., Wu,D., Yu,G.,
Fraser,C.M., Venter,J.C. and Davis,R.W.
TITLE Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana
JOURNAL Nature 408 (6814), 816-820 (2000)
PUBMED 11130712
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=cv. Columbia
REFERENCE 2 (residues )
AUTHORS Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
Schobel,S. and Town,C.D.
TITLE Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome
JOURNAL Plant J 89 (4), 789-804 (2017)
PUBMED 27862469
REMARK GENOME REANNOTATION.;
STRAIN=cv. Columbia
REFERENCE 3 (residues )
AUTHORS Yamada,K., Lim,J., Dale,J.M., Chen,H., Shinn,P., Palm,C.J.,
Southwick,A.M., Wu,H.C., Kim,C., Nguyen,M., Pham,P., Cheuk,R.,
Karlin-Newmann,G., Liu,S.X., Lam,B., Sakano,H., Wu,T., Yu,G.,
Miranda,M., Quach,H.L., Tripp,M., Chang,C.H., Lee,J.M., Toriumi,M.,
Chan,M.M., Tang,C.C., Onodera,C.S., Deng,J.M., Akiyama,K.,
Ansari,Y., Arakawa,T., Banh,J., Banno,F., Bowser,L., Brooks,S.,
Carninci,P., Chao,Q., Choy,N., Enju,A., Goldsmith,A.D., Gurjal,M.,
Hansen,N.F., Hayashizaki,Y., Johnson-Hopson,C., Hsuan,V.W.,
Iida,K., Karnes,M., Khan,S., Koesema,E., Ishida,J., Jiang,P.X.,
Jones,T., Kawai,J., Kamiya,A., Meyers,C., Nakajima,M., Narusaka,M.,
Seki,M., Sakurai,T., Satou,M., Tamse,R., Vaysberg,M.,
Wallender,E.K., Wong,C., Yamamura,Y., Yuan,S., Shinozaki,K.,
Davis,R.W., Theologis,A. and Ecker,J.R.
TITLE Empirical analysis of transcriptional activity in the Arabidopsis
genome
JOURNAL Science 302 (5646), 842-846 (2003)
PUBMED 14593172
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
STRAIN=cv. Columbia
REFERENCE 4 (residues )
AUTHORS Brover,V.V., Troukhan,M.E., Alexandrov,N.A., Lu,Y.-P., Flavell,R.B.
and Feldmann,K.A.
TITLE Direct Submission
JOURNAL Submitted (??-MAR-2002) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
REFERENCE 5 (residues )
AUTHORS Bauwe,H. and Kolukisaoglu,U.
TITLE Genetic manipulation of glycine decarboxylation
JOURNAL J Exp Bot 54 (387), 1523-1535 (2003)
PUBMED 12730263
REMARK REVIEW.
REFERENCE 6 (residues )
AUTHORS Zhang,Y., Sun,K., Sandoval,F.J., Santiago,K. and Roje,S.
TITLE One-carbon metabolism in plants: characterization of a plastid
serine hydroxymethyltransferase
JOURNAL Biochem J 430 (1), 97-105 (2010)
PUBMED 20518745
REMARK GENE FAMILY.
COMMENT On or before Jun 5, 2013 this sequence version replaced
gi:75246061, gi:75262210.
[FUNCTION] Catalyzes the interconversion of serine and glycine.
{ECO:0000250}.
[CATALYTIC ACTIVITY]
Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine +
H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine;
Xref=Rhea:RHEA:15481, ChEBI:CHEBI:15377, ChEBI:CHEBI:15636,
ChEBI:CHEBI:33384, ChEBI:CHEBI:57305, ChEBI:CHEBI:57453;
EC=2.1.2.1.
[COFACTOR] Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Evidence={ECO:0000250}.
[PATHWAY] One-carbon metabolism; tetrahydrofolate interconversion.
[SUBUNIT] Homotetramer. {ECO:0000250}.
[SUBCELLULAR LOCATION] Cytoplasm {ECO:0000305}.
[SIMILARITY] Belongs to the SHMT family. {ECO:0000305}.
[SEQUENCE CAUTION] Sequence=AAG52195.1; Type=Erroneous initiation;
Note=Truncated N-terminus.; Evidence={ECO:0000305};
Sequence=AAM61506.1; Type=Erroneous initiation; Note=Truncated
N-terminus.; Evidence={ECO:0000305}.
FEATURES Location/Qualifiers
source 1..14
/organism="Arabidopsis thaliana"
/db_xref="taxon:3702"
gene <1..>14
/gene="SHM7"
/locus_tag="At1g36370"
/gene_synonym="F7F23.9"
/gene_synonym="SHMT7"
Protein <1..>14
/product="Serine hydroxymethyltransferase 7"
/EC_number="2.1.2.1"
/note="AtSHMT7; Glycine hydroxymethyltransferase 7; Serine
methylase 7"
/UniProtKB_evidence="Evidence at protein level"
Region <1..>14
/region_name="Mature chain"
/note="Serine hydroxymethyltransferase 7.
/id=PRO_0000422352."
Region <1..>14
/region_name="PLN02271"
/note="serine hydroxymethyltransferase"
/db_xref="CDD:215153"
Region 1..14
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:7QX8."
ORIGIN
1 nnhiaalaia lkqv
//