LOCUS       TRMD_GEOKA               244 aa            linear   BCT 27-NOV-2024
DEFINITION  RecName: Full=tRNA (guanine-N(1)-)-methyltransferase; AltName:
            Full=M1G-methyltransferase; AltName: Full=tRNA [GM37]
            methyltransferase.
ACCESSION   Q5L0P4
VERSION     Q5L0P4.1
DBSOURCE    UniProtKB: locus TRMD_GEOKA, accession Q5L0P4;
            class: standard.
            created: May 10, 2005.
            sequence updated: Feb 1, 2005.
            annotation updated: Nov 27, 2024.
            xrefs: BA000043.1, BAD75486.1, WP_011230701.1
            xrefs (non-sequence databases): AlphaFoldDB:Q5L0P4, SMR:Q5L0P4,
            STRING:235909.GK1201, KEGG:gka:GK1201, eggNOG:COG0336,
            HOGENOM:CLU_047363_0_1_9, Proteomes:UP000001172, GO:0005829,
            GO:0052906, GO:0002939, CDD:cd18080, FunFam:1.10.1270.20:FF:000001,
            FunFam:3.40.1280.10:FF:000001, Gene3D:3.40.1280.10,
            Gene3D:1.10.1270.20, HAMAP:MF_00605, InterPro:IPR029028,
            InterPro:IPR023148, InterPro:IPR002649, InterPro:IPR029026,
            InterPro:IPR016009, NCBIfam:TIGR00088, PANTHER:PTHR46417,
            PANTHER:PTHR46417:SF1, Pfam:PF01746, PIRSF:PIRSF000386,
            SUPFAM:SSF75217
KEYWORDS    Cytoplasm; Methyltransferase; Reference proteome;
            S-adenosyl-L-methionine; Transferase; tRNA processing.
SOURCE      Geobacillus kaustophilus HTA426
  ORGANISM  Geobacillus kaustophilus HTA426
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Geobacillus; Geobacillus thermoleovorans group.
REFERENCE   1  (residues 1 to 244)
  AUTHORS   Takami,H., Takaki,Y., Chee,G.J., Nishi,S., Shimamura,S., Suzuki,H.,
            Matsui,S. and Uchiyama,I.
  TITLE     Thermoadaptation trait revealed by the genome sequence of
            thermophilic Geobacillus kaustophilus
  JOURNAL   Nucleic Acids Res 32 (21), 6292-6303 (2004)
   PUBMED   15576355
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=HTA426
            Publication Status: Online-Only
COMMENT     [FUNCTION] Specifically methylates guanosine-37 in various tRNAs.
            {ECO:0000255|HAMAP-Rule:MF_00605}.
            [CATALYTIC ACTIVITY] Reaction=guanosine(37) in tRNA +
            S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA +
            S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:36899,
            Rhea:RHEA-COMP:10145, Rhea:RHEA-COMP:10147, ChEBI:CHEBI:15378,
            ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73542,
            ChEBI:CHEBI:74269; EC=2.1.1.228;
            Evidence={ECO:0000255|HAMAP-Rule:MF_00605}.
            [SUBUNIT] Homodimer. {ECO:0000255|HAMAP-Rule:MF_00605}.
            [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00605}.
            [SIMILARITY] Belongs to the RNA methyltransferase TrmD family.
            {ECO:0000255|HAMAP-Rule:MF_00605}.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Geobacillus kaustophilus HTA426"
                     /db_xref="taxon:235909"
     gene            1..244
                     /gene="trmD"
                     /locus_tag="GK1201"
     Protein         1..244
                     /product="tRNA (guanine-N(1)-)-methyltransferase"
                     /EC_number="2.1.1.228"
                     /note="M1G-methyltransferase; tRNA [GM37]
                     methyltransferase"
                     /UniProtKB_evidence="Inferred from homology"
     Region          1..244
                     /region_name="Mature chain"
                     /note="tRNA (guanine-N(1)-)-methyltransferase.
                     /id=PRO_0000060380."
     Region          1..242
                     /region_name="TrmD"
                     /note="tRNA G37 N-methylase TrmD [Translation, ribosomal
                     structure and biogenesis]; COG0336"
                     /db_xref="CDD:440105"
ORIGIN      
        1 mridiltlfp gmfsgvlses ilkkaqekga vdirlidfre fadnkhktvd dypygggagm
       61 vlkpqpifda vehvtagspg ariillcpqg erytqkkaee lakethlvli cghyegyder
      121 irqylatdei sigdyiltgg elgamvivds vvrllpgvlg neaspvddsf ssglleypqy
      181 trpadfrgmk vpdillsgnh qliaewreke slrrtflrrp dlldeypltd kqkqwlkewe
      241 kere
//