RecName: Full=R-spondin-1; AltName: Full=Roof plate-specific spondin-1 - Protein

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Protein 3D Structure

crystal structure of human LGR4 and Rspo1

PDB: 4QXF

Source: synthetic construct, Homo sapiens

Method: X-ray Diffraction

Resolution: 2.25 Å

See all 10 structures...

Articles about the RSPO1 gene

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity. [Adv Sci (Weinh). 2023]
Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity.
Sun Y, Zhang J, Hong J, Zhang Z, Lu P, Gao A, Ni M, Zhang Z, Yang H, Shen J, et al. Adv Sci (Weinh). 2023 Apr; 10(12):e2207152. Epub 2023 Feb 8.
RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell-cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development. [Orphanet J Rare Dis. 2022]
RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell-cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development.
Dellambra E, Cordisco S, Delle Monache F, Bondanza S, Teson M, Nicodemi EM, Didona B, Condorelli AG, Camerino G, Castiglia D, et al. Orphanet J Rare Dis. 2022 Jul 19; 17(1):275. Epub 2022 Jul 19.
The role of R-spondin 1 through activating Wnt/β-catenin in the growth, survival and migration of ovarian cancer cells. [Gene. 2019]
The role of R-spondin 1 through activating Wnt/β-catenin in the growth, survival and migration of ovarian cancer cells.
Liu Q, Zhao Y, Xing H, Li L, Li R, Dai J, Li Q, Fang S. Gene. 2019 Mar 20; 689:124-130. Epub 2018 Dec 17.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the RSPO1 gene (NG_012239.2).
RefSeq protein isoforms
See 6 reference sequence protein isoforms for the RSPO1 gene.

More about the RSPO1 gene

This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded ...
Also Known As: CRISTIN3, RSPO

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Q2MKA7
Domain Mapping of Disease Mutations
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RecName: Full=R-spondin-1; AltName: Full=Roof plate-specific spondin-1; Short=hRspo1; Flags: Precursor

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Articles about the RSPO1 gene

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